B-cell suppression of delayed hypersensitivity reactions

Measurement of Serum Levels of Interleukin 17 and 23 in the Immune System with Different Amounts of Spleens White Pulp Size after Inoculation of New Leishmania Vaccine in Susceptible Mice

“…These findings were showed that our new leishmania vaccine could affect the spleen tissue; however the effect was moderate as shown previously. The interesting point is that the group LB which received 100 or 200 µg/0.1 ml had lowest mean of spleen white pulp size, but they had the highest mean number of spleen white pulp and thus had highest levels of white pulp expansion (71191.45 micron).The results confirmed our previous theory about regulation of homeostasis in vivo in different situations [34] but injection group LT for both injection doses 100 and 200 µg/0.1 ml had lowest levels of spleen white pulp expansion (64923. 0).…”

“…According to our present and previous experiments on Balb/C mice [20][21][22][23][24], the vaccine seem to be safe and effective; 100% viability was recorded in all groups vaccinated with different doses of antigen (100 µg/0.1 ml or 200 µg/0.1 ml) with BCG or alcoholic extract of T. polium and or both as adjuvant. The provisional vaccine induced satisfactory cytokine responses in such a way that are not only safe to the vaccinated animals (Balb/C mice), could protect vaccinated subjects against challenging with live leishmania parasite as shown previously [30,31]. There are some suggestions related to the vaccine: The immune responses against organism leading to intracellular destruction or blocking some unknown ligands necessary to the course of the life cycle continuity or survival of organisms within the vertebrate host.…”

Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell.

“…Investigators employing experimental animal models have identified suppressor cells that influence many aspects of T-and B-cell function (for review, see 41). Furthermore, T-cell, B-cell, and macrophage subpopulations have been implicated as suppressor cells (38,39,42).…”

Mitogenic analysis of murine B-cell heterogeneity.

“…Thus, those B cells that give rise to antibody-producing cells can be divided into a subset that requires cooperation with T-derived lymphocytes and another subset that is T independent (1-6). Recently, it has been shown that the B-cell population also contains suppressor cells that regulate various functions of T cells (7)(8)(9)(10)(11) and that these suppressor cells seem to be different from antibody-producing cells (10, 11).There is contradictory evidence as to whether the response to different mitogens defines different B-cell subpopulations. In mice, Melchers and Andersson (12) concluded that PPD and lipepelysaccharide (LPS) I stimulate the same cell, whereas Gronowicz and Coutinho (13) The aim of this work was to test directly various alternative hypotheses that could explain the differences in the responsiveness of routine B lymphocytes with regard to various mitogens: (a) One cell possesses the receptors for various mitogens and can be stimulated by all known murine B-cell mitogens separately; (b) the ability to respond to various mitogens depends on the stage of maturation of the B cell; (c) there are different subsets of lymphocytes for different mitogens.…”