B cells as antigen presenting cells

Rodríguez-Pinto, Daniel

doi:10.1016/j.cellimm.2006.02.005

Cited by 262 publications

(209 citation statements)

References 94 publications

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“…Second, while CD20 is present on the surface of all mature B cells [33][34][35], and CD19 is predominantly expressed on B cells [36] [39,40]. B cells are capable of influencing T cell memory, survival, and proliferation [41,42], as well as presenting antigen to both CD4 + and CD8 + T cells [38,43] …”

Section: Intraepithelial Presence Of B Cells Was Positively Correlamentioning

confidence: 99%

Antigen-Presenting Cell (APC) Subsets in Ovarian Cancer

Wilke

Kryczek

Zou

2011

International Reviews of Immunology

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Section: Intraepithelial Presence Of B Cells Was Positively Correlamentioning

confidence: 99%

Antigen-Presenting Cell (APC) Subsets in Ovarian Cancer

Wilke

Kryczek

Zou

2011

International Reviews of Immunology

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“…BCR cross-linking induces a signaling cascade leading to internalization and processing of the bound Ag, cytokine production, and up-regulation of costimulatory molecules (19). Other factors that strongly influence B cell activation are complement binding through the complement receptors CD21 and CD35 as well as TLR interaction (20 -22).…”

Section: H Ost Cells Express Various Pathogen Recognition Receptors (mentioning

confidence: 99%

Superantigen- and TLR-Dependent Activation of Tonsillar B Cells after Receptor-Mediated Endocytosis

Jendholm

Mörgelin

Vidakovics

et al. 2009

The Journal of Immunology

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Classical B lymphocyte activation is dependent on BCR cross-linking in combination with physical interaction with Th cells. Other B cell molecules that contribute to the activation are complement, cytokine, and TLRs recognizing specific pathogen-associated molecular patterns. Moraxella (Branhamella) catarrhalis is a common Gram-negative respiratory pathogen that induces proliferation in human IgD-expressing B cells independently of T cell help. The activation is initiated by the B cell superantigen Moraxella IgD-binding protein (MID) through a nonimmune cross-linking of IgD. However, IgD cross-linking alone is not sufficient to induce proliferation. In this study, we characterized the significance of TLRs in superantigen-dependent B cell activation using whole bacteria or rMID in the presence or absence of TLR ligands. IgD cross-linking by MID sensitized B cells obtained from children with tonsillar hyperplasia for mainly TLR9, whereas TLRs 1, 2, 6, and 7 were less important. The Moraxella-induced activation was inhibited when a dominant-negative TLR9 ligand was added. Interestingly, BCR-mediated endocytosis of whole Moraxella and degradation of live bacteria in naive B cells were observed with fluorescence, confocal, and transmission electron microscopy. This unique observation proved the strong intracellular TLR9 response as well as highlighted the Ag-presenting function of B cells. In conclusion, our findings suggest an important role of TLRs in the adaptive immune response and reveal novel insights into the T cell-independent B cell activation induced by bacteria.

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“…Less attention has been paid to B cells and their role in host defense against tumors (5). B cells may contribute to this process in multiple ways, for instance, by presenting Ags to T cells (5,6). In particular, the high-affinity binding of the BCR to its specific target makes the B cell able to sense and react to small amounts of Ag in the environment, which clearly is an advantage over other APCs.…”

mentioning

confidence: 99%

Multiplex B Cell Characterization in Blood, Lymph Nodes, and Tumors from Patients with Malignancies

Zirakzadeh

Marits

Sherif

et al. 2013

The Journal of Immunology

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B lymphocytes contribute to immune surveillance, by tumor-specific Abs and Ag presentation to T lymphocytes, but are insufficiently studied in humans. In this article, we report a flow cytometric investigation of B lymphocyte subpopulations in blood, lymph nodes (LNs), and malignant tissues from 20 patients operated on because of advanced solid tumors. The CD19+ compartment in peripheral blood was essentially unaltered in patients, as compared with healthy control subjects. In metastatic LNs, signs of B lymphocyte activation were observed, as evidenced by increased proportions of plasmablasts and CD86-expressing cells. In tumor-infiltrating B lymphocytes (TIL-B), both switched memory cells and plasmablasts were expanded, as compared with nonmalignant epithelium. Moreover, pronounced skewing of Igλ/Igκ ratio was evident among TIL-Bs. By spectratype analysis on IgH, we confirmed a monoclonal expansion of the Vh7 family in TIL-B, also present in a tumor-associated LN. Sequencing the clonally expanded Vh7 revealed signs of somatic hypermutation. In conclusion, B lymphocytes in cancer patients exhibit signs of activation in tumor-associated tissues, likely induced by recognition of tumor Ags. Increased numbers of switched memory cells and plasmablasts in combination with clonal expansion and signs of somatic hypermutation suggest a CD4+ T lymphocyte–dependent antitumoral response, which may be exploited for immunotherapy.

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B cells as antigen presenting cells

Cited by 262 publications

References 94 publications

Antigen-Presenting Cell (APC) Subsets in Ovarian Cancer

Antigen-Presenting Cell (APC) Subsets in Ovarian Cancer

Superantigen- and TLR-Dependent Activation of Tonsillar B Cells after Receptor-Mediated Endocytosis

Multiplex B Cell Characterization in Blood, Lymph Nodes, and Tumors from Patients with Malignancies

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