B Cells Specific CpG Induces High IL-10 and IL-6 Expression In Vitro in Neuro-Behçet’s Disease

Maghrebi, Olfa; Belghith, Mériam; Jeridi, Cyrine; Rachdi, Amine; Fatnassi, Fatma Nabli; Saied, Mohamed Zakaria; Belal, Samir; Sassi, Samia Ben; Barbouche, Mohamed‐Ridha

doi:10.3390/cells11081306

Cited by 6 publications

(4 citation statements)

References 64 publications

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“…Published data indicate that CpG ODN can facilitate immune regulation [17]. We were pondering if CpG could boost the expression of IL‐10 in M0 cells caused by CD40L.…”

Section: Resultsmentioning

confidence: 99%

Oligodeoxynucleotides containing CpG motifs (CpG‐ODN) restores immune regulatory functions of airway macrophages of patients with asthma

Zhang,

Wang,

Zhang

et al. 2024

Immunology

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Allergic asthma is characterized by the polarization of Th2 cells and impaired immune regulation. Macrophages occupy the largest proportion of airway immune cells. This study aims to discover the mechanism that hinders the immune regulatory functions of airway macrophages. In this study, macrophages were isolated from cells in bronchoalveolar lavage fluids (BALF) collected from asthma patients and normal control (NC) subjects. The results indicated that macrophages occupied the largest portion of the cellular components in BALF. The frequency of IL‐10+ macrophage was significantly lower in asthma patients than in NC subjects. The expression of IL‐10 in macrophages of BALF was associated with the levels of asthma‐related parameters. The immune‐suppressive functions of BALF M0 cells were defective in asthma patients. The inducibility of IL‐10 expression was impaired in BALF macrophages of asthma patients, which could be restored by exposing to CpG. In conclusion, the induction of IL‐10 in macrophages of BALF in asthma patients was impaired, and it could be restored by exposure to CpG.

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“…Published data indicate that CpG ODN can facilitate immune regulation [17]. We were pondering if CpG could boost the expression of IL‐10 in M0 cells caused by CD40L.…”

Section: Resultsmentioning

confidence: 99%

Oligodeoxynucleotides containing CpG motifs (CpG‐ODN) restores immune regulatory functions of airway macrophages of patients with asthma

Zhang,

Wang,

Zhang

et al. 2024

Immunology

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“…When investigating the gene expression f IL-6 in BD patients Yamakawa et al suggested that gene expression is not specific for BD [2]. Besides Jiang et al showed that increased secretion in BD, Maghrebi presented increased expressions of interleukins such as IL-6 or IL-10 may help to understand the pathophysiology of neuro-inflammatory disorders like multiple sclerosis (MS) and BD [10,31]. All these inconsistent results have led to researchers to study the associations and possible susceptible polymorphisms of IL-6 in BD patients.…”

Section: Discussionmentioning

confidence: 99%

Associations of IL-6 polymorphisms with Behçet’s Disease in Denizli, province of Turkey

Arıkan¹

2022

Med-Science

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Behçet's Disease is a chronic, multisystemic disease and the etiopathogenesis of the disease develop as a result of the interaction of environmental and genetic factors. IL-6 is a proinflammatory cytokine with functions on immune response regulation and chronic inflammation demonstrated by increased serum levels and gene expression studies in Behçet’s disease. We genotyped IL-6; rs1800797, rs1800796 and rs1800795 polymorphisms in 78 patients with Behçet’s disease and 130 healthy controls using PCR-RFLP based approach. No statistically significant difference in allele or genotype frequencies of IL-6, rs1800797 and rs1800796 was found in between groups. We determined that in the BD patients with genital ulcers, arthritis and without vascular involvement was found to have significantly different IL-6, SNP frequencies compared with healthy controls. In addition, the IL-6 rs1800795 GC genotype and C allele may contribute to the development of the disease in female BD. The haplotype distributions of all loci of IL-6 were examined and GGG was found as the highest frequency haplotype in both groups. In conclusion, the results of our study showed that IL-6 rs1800795 may associate with the susceptibility to the BD. Studies should be conducted with more SNPs in large and different populations need to evaluate the contribution of responsible alleles for the disease and its clinical features.

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“…In humans, the stimulation of B cells with CpG, a ligand for Toll-like receptor 9 (TLR9), one of the TLRs, and various cytokines such as interferon-a, interleukin-2 (IL-2), and interleukin-6 (IL-6), induces differentiation into plasmablasts [40,[57][58][59][60][61]. The in vitro stimulation of B cells isolated from the peripheral blood of healthy individuals with CpG and cytokines induces differentiation into two types of plasmablasts: weakly CD27-positive and strongly CD27-positive.…”

Section: A Group Of B Cells Called Plasmablasts Control Encephalomyel...mentioning

confidence: 99%

Unraveling the Immunopathogenesis of Multiple Sclerosis: The Dynamic Dance of Plasmablasts and Pathogenic T Cells

Matsuzaka,

Yashiro

2023

Biologics

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Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, characterized by multiple lesions occurring temporally and spatially. Additionally, MS is a disease that predominates in the white population. In recent years, there has been a rapid increase in the number of patients, and it often occurs in young people, with an average age of onset of around 30 years old, but it can also occur in children and the elderly. It is more common in women than men, with a male-to-female ratio of approximately 1:3. As the immunopathogenesis of MS, a group of B cells called plasmablasts controls encephalomyelitis via IL-10 production. These IL-10-producing B cells, called regulatory B cells, suppress inflammatory responses in experimental mouse models of autoimmune diseases including MS. Since it has been clarified that these regulatory B cells are plasmablasts, it is expected that the artificial control of plasmablast differentiation will lead to the development of new treatments for MS. Among CD8-positive T cells in the peripheral blood, the proportion of PD-1-positive cells is decreased in MS patients compared with healthy controls. The dysfunction of inhibitory receptors expressed on T cells is known to be the core of MS immunopathology and may be the cause of chronic persistent inflammation. The PD-1+ CD8+ T cells may also serve as indicators that reflect the condition of each patient in other immunological neurological diseases such as MS. Th17 cells also regulate the development of various autoimmune diseases, including MS. Thus, the restoration of weakened immune regulatory functions may be a true disease-modifying treatment. So far, steroids and immunosuppressants have been the mainstream for autoimmune diseases, but the problem is that this kills not only pathogenic T cells, but also lymphocytes, which are necessary for the body. From this understanding of the immune regulation of MS, we can expect the development of therapeutic strategies that target only pathogenic immune cells.

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B Cells Specific CpG Induces High IL-10 and IL-6 Expression In Vitro in Neuro-Behçet’s Disease

Cited by 6 publications

References 64 publications

Oligodeoxynucleotides containing CpG motifs (CpG‐ODN) restores immune regulatory functions of airway macrophages of patients with asthma

Oligodeoxynucleotides containing CpG motifs (CpG‐ODN) restores immune regulatory functions of airway macrophages of patients with asthma

Associations of IL-6 polymorphisms with Behçet’s Disease in Denizli, province of Turkey

Unraveling the Immunopathogenesis of Multiple Sclerosis: The Dynamic Dance of Plasmablasts and Pathogenic T Cells

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