B Cells That Produce Immunoglobulin E Mediate Colitis in BALB/c Mice

Hoving, J. Claire; Kirstein, Frank; Nieuwenhuizen, Natalie E.; Fick, Lizette; Hobeika, Elias; Reth, Michael; Brombacher, Frank

doi:10.1053/j.gastro.2011.09.044

Cited by 42 publications

(45 citation statements)

References 53 publications

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“…Using a mouse model of acute oxazolone-induced colitis,7 8 we confirmed that IL-13-deficient mice are protected from developing colitis (table 1, see IL-13 −/− , online supplementary figure S1 and figure S2). …”

mentioning

confidence: 52%

Interleukin 13-mediated colitis in the absence of IL-4Rα signalling

Hoving

Cutler

Leeto

et al. 2017

Gut

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mentioning

confidence: 52%

Interleukin 13-mediated colitis in the absence of IL-4Rα signalling

Hoving

Cutler

Leeto

et al. 2017

Gut

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“…Indeed, elevated serum IgE levels have been reported in UC patients 71,72 , and in oxazalone-induced murine colitis 73 . Accordingly, B cells contribute to oxazalone-induced colitisin a manner that requires the IL-4 receptor alpha chain (IL-4Rα) 73 .…”

Section: Cd4+ T Cells In Ibdmentioning

confidence: 99%

Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases

Chen

Sundrud

2016

Inflammatory Bowel Diseases

135

104

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Pathogenesis of the inflammatory bowel diseases (IBDs) ulcerative colitis (UC) and Crohn’s disease (CD) involve pro-inflammatory changes within the microbiota, chronic immune-mediated inflammatory responses, and epithelial dysfunction. Converging data from genome-wide association studies (GWAS), mouse models of IBD, and clinical trials indicate that cytokines are key effectors of both normal homeostasis and chronic inflammation in the gut. Yet still many questions remain concerning the role of specific cytokines in different IBDs, within distinct regions of the gut, and with regard cellular mechanisms of action. Here we review current and emerging concepts concerning the role of cytokines in IBD, with a focus on immune regulation, T cell subsets, and potential clinical applications.

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“…Generation, characterization, and genotyping of mb1 cre IL-4Rα -/lox BALB/c mice are previously described (17). All mice were housed in specific pathogen-free barriers at the University of Cape Town animal facility.…”

Section: Generation and Genotyping Of Mb1mentioning

confidence: 99%

“…cre IL-4Rα -/lox BALB/c mice (17), to investigate the role of IL-4Rα-responsive B cells during parasitic…”

mentioning

confidence: 99%

IL-4–producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases

Hurdayal

Ndlovu

Revaz-Breton

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Interleukin-4 (IL-4)-induced T helper (Th) 2 cells promote susceptibility to the protozoan parasite Leishmania major, while conferring immunity to the intestinal trematode Schistosoma mansoni. Here, we report that abrogation of IL-4 receptor alpha (IL-4Rα) signaling on B cells in BALB/c mice (mb1 cre IL-4Rα -/lox ) transformed nonhealer BALB/c to a healer phenotype with an early type 1 and dramatically reduced type 2 immune response and an absence of ulceration and necrosis during cutaneous leishmaniasis. From adoptive reconstitution and mixed bone-marrow chimera studies in B cell-deficient (μMT) mice, we reveal a central role for B cellderived IL-4 and IL-4Rα in the optimal induction of the susceptible type 2 phenotype to L. major infection. We further demonstrate that the absence of IL-4Rα signaling on B cells exacerbated S. mansoniinduced mortality and pathology in BALB/c mice, due to a diminished type 2 immune response. In both disease models, IL-4Rα-responsive B cells displayed increased IL-4 production as early as day 1 after infection. Together, these results demonstrate that IL-4-producing and IL-4Rα-responsive B cells are critical in regulating and assisting early T helper dichotomy toward Th2 responses, which are detrimental in cutaneous leishmaniasis but beneficial in acute schistosomiasis.IL-4R alpha | B cells | leishmaniasis | schistosomiasis | mouse

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B Cells That Produce Immunoglobulin E Mediate Colitis in BALB/c Mice

Cited by 42 publications

References 53 publications

Interleukin 13-mediated colitis in the absence of IL-4Rα signalling

Interleukin 13-mediated colitis in the absence of IL-4Rα signalling

Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases

IL-4–producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases

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