B-mode ultrasound images of the carotid artery wall: correlation of ultrasound with histological measurements

Gamble, Greg; Beaumont, Brent; Smith, Heidi J.; Zorn, J; Sanders, Gregory P.; Merrilees, Mervyn J.; MacMahon, Stephen; Sharpe, Norman

doi:10.1016/0021-9150(93)90158-q

Cited by 103 publications

(64 citation statements)

References 28 publications

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“…It was recently demonstrated that CAWT and IMT show consistent results 16 (with the Bland-Altman statistic, the discrepancy was 0.023 mm), supporting the observation by Gamble et al 21 that sonographic IMT measurements best correspond with histologically ascertained total artery wall thickness (ie, including the tunica adventia), rather than with the intima plus media complex per se. On the basis of these data, the authors considered the 2 methods to be interchangeable.…”

Section: Discussionsupporting

confidence: 69%

Associations between Carotid Artery Wall Thickness and Cardiovascular Risk Factors Using Multidetector CT

Saba¹,

Sanfilippo²,

Montisci³

et al. 2010

AJNR Am J Neuroradiol

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Section: Discussionsupporting

confidence: 69%

Associations between Carotid Artery Wall Thickness and Cardiovascular Risk Factors Using Multidetector CT

Saba¹,

Sanfilippo²,

Montisci³

et al. 2010

AJNR Am J Neuroradiol

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“…To simplify the scanning procedure, and because of the lesser stability of measurements of the internal and external carotid artery, these segments were not taken into consideration in the present study (19,27). The IMT of the posterior (far) wall of both common carotid arteries was measured as the distance between the junction of the lumen and intima and that of the media and adventitia (27,28).…”

Section: Carotid Imt Assessmentmentioning

confidence: 99%

Correlates of increased lean muscle mass in women with polycystic ovary syndrome

Carmina¹,

Guastella²,

Longo³

et al. 2009

European Journal of Endocrinology

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Objective: Muscle mass plays an important role in determining cardiovascular and metabolic risks in polycystic ovary syndrome (PCOS). In addition, whether lean mass influences carotid intima-media thickness (IMT) in PCOS has not been assessed. Design: Prospective investigation. Methods: Ninety-five women with PCOS were age-and weight-matched to 90 ovulatory controls. All women had dual X-ray absorptiometry for lean, fat and bone mass, and bone mass density (BMD). Serum testosterone, sex hormone-binding globulin, insulin, and glucose and carotid IMT were determined. Free androgen index (FAI) and insulin resistance (by QUICKI) were calculated. Results: In PCOS, waist circumference and insulin were higher and QUICKI lower than in controls (P!0.01). Trunk fat mass, % trunk fat, and lean mass were higher in PCOS compared to controls (P!0.01), while total bone mass and BMD were similar. IMT was increased in PCOS (P!0.01) but only 15% of PCOS patients had abnormal (R0.9 mm) values. Lean mass correlated with fat parameters, insulin, QUICKI, and FAI, but not with total testosterone; and after adjustments for insulin and QUICKI, lean mass still correlated with fat mass (P!0.01) but not FAI. Lean mass correlated with IMT (P!0.01), but this was dependent on insulin. However, excluding those patients with abnormal IMT values, IMT correlated with lean mass independently of insulin. Bone mass correlated with lean and fat mass, but not with insulin or androgen. PCOS patients with 'pathological' IMT values had higher % trunk fat, lean mass, and insulin, lower QUICKI, and higher testosterone and FAI compared with those with normal IMT. Conclusion: Lean mass is increased in PCOS, while bone mass is similar to that of matched controls. The major correlates of lean mass are fat mass and insulin but not androgen. Lean mass also correlated with IMT, and although influenced by insulin, small changes in IMT may partially reflect changes in muscle mass, while clearly abnormal values relate to more severe abnormalities of PCOS.

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“…Based on the work of Pignoli and colleagues, 30 it has become accepted, though not without challenge, 31 that the outer line corresponds anatomically to the media-adventitia interface. It is generally agreed that the inner line corresponds to the lumen-intima interface.…”

Section: Image Analysismentioning

confidence: 99%

Age-Related Deterioration in Arterial Structure and Function in Postmenopausal Women

McGrath

Liang

Teede

et al. 1998

ATVB

122

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Abstract-Epidemiological evidence suggests that hormone replacement therapy (HRT) reduces morbidity and mortality from cardiovascular diseases in postmenopausal women. In this study, indices of arterial function [total systemic arterial compliance (SAC) and carotid arterial distensibility coefficient (DC)], structure [carotid intima-media thickness (IMT)], and lipid profiles were compared in postmenopausal women on long-term HRT and aged-matched controls. One hundred nine women aged 44 to 77 years taking HRT and an age-matched group of 108 female controls were entered into the study. The two groups were similar for body mass index, smoking status, exercise level, alcohol intake, and blood pressure. Fasting cholesterol, low density lipoprotein, and lipoprotein(a) were reduced and high density lipoprotein increased in the HRT group. IMT increased with age; SAC and DC were reduced with age in both groups. The HRT group had a higher mean SAC (0.42Ϯ0.02 versus 0.34Ϯ0.02 U/mm Hg, Pϭ0.0001) and a lower mean IMT (0.67Ϯ0.01 versus 0.74Ϯ0.02 mm, Pϭ0.006) than did controls. Subgroup analysis for estrogen versus estrogen plus progestin revealed no differences for SAC and IMT; DC, however, was greater in estrogen-only users. Smokers on HRT had a higher mean SAC (0.41Ϯ0.02 versus 0.31Ϯ0.01 U/mm Hg, Pϭ0.008) and a lower IMT (0.65Ϯ0.02 versus 0.75Ϯ0.03 mm, Pϭ0.002) than did smokers not taking such therapy. A protective effect of long-term estrogen therapy on age-related changes in arterial structure and function in postmenopausal women was evident in smokers and nonsmokers alike. Progestin appeared to counteract the effects of estrogen on carotid compliance only. Long-term controlled trials are needed to determine the significance of these findings.

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B-mode ultrasound images of the carotid artery wall: correlation of ultrasound with histological measurements

Cited by 103 publications

References 28 publications

Associations between Carotid Artery Wall Thickness and Cardiovascular Risk Factors Using Multidetector CT

Associations between Carotid Artery Wall Thickness and Cardiovascular Risk Factors Using Multidetector CT

Correlates of increased lean muscle mass in women with polycystic ovary syndrome

Age-Related Deterioration in Arterial Structure and Function in Postmenopausal Women

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