New Reagent for Labeling Organic Compounds with Tritium

Die Renaissance des H/D‐Austausches

“…Da natürlich umgekehrt an diesen Positionen Deuterium genauso schnell wieder gegen Wasserstoff zurückgetauscht werden kann, sind oft weitere chemische Schritte notwendig, um eine Desaktivierung dieser Markierungsposition zu erzielen. [19] zum Einsatz kommt. [20] [20] Schema 6.…”

Tritium-labelled alkaloids: Synthesis and applications

“…Isolated from the seeds of Peganum harmala , the harmala family of indole alkaloids (formally β‐carbolines) contains several members that function as reversible inhibitors of the enzyme monoamine oxidase A. Using a general exchange tritiation method, early workers had labelled harmaline with tritium but only at very low specific activity . To synthesize [ 3 H]harmaline ( 5 ) at a specific activity suitable for receptor binding assay, the French National Institute of Health and Medical Research investigators used the route shown in Scheme , obtaining 5 at 37 Ci/mmol .…”

Radiosynthesis of 3′-Chloro-3-nitrosalicylanilide and Determination of Its Uptake by Lamprey Larvae

“…Preparation of the Labeled Reagent-Tritiated phosphoric acid saturated with boron trifluoride (BFs) was prepared by the method of Yavorsky and Gorin (13). Two-tenths milliliter of tritiated water, with an initial specific activity of 500 mc./ml., was diluted to 5 ml., using triple-distilled deionized water.…”