Supramolecular Vesicles Based on Water‐Soluble 2,6‐Helic[6]arene: High Affinity Binding, Stimuli Responsiveness and Delivery of Doxorubicin to Cancer Cells

Abstract

of main observation and conclusion arene was used to construct supramolecular vesicles via host-guest interaction. Water-soluble 2,6-helic[6]arene was discovered to be high affinity host for suitable biomarkers. Supramolecular vesicles were responsive to multiple stimuli types, including temperature, pH, Ca 2+ , CO 2 bubbling and biomarker displacement. Supramolecular vesicles were used to load and deliver antitumor drug doxorubicin to HeLa cells in vitro.www.cjc.wiley-vch.de

Acetal-Functionalized Pillar[5]arene: A pH-Responsive and Versatile Nanomaterial for the Delivery of Chemotherapeutic Agents

“…As shown in Figure S19, resonances for pyridinium protons H 1 –H 2 had a significant upfield shift in 1 H NMR spectra, indicating supramolecular encapsulation inside the cavity of host 1 . Folic-acid-modified drug-encapsulated nanoparticles (FA-DOX-NPs and FA-PTX-NPs) as targeted chemotherapeutic agents were prepared by adding FA-Py into the systems during the emulsion process . Drug-encapsulated nanoparticles (DOX-NPs and PTX-NPs) were prepared as control groups.…”

“…Folic-acid-modified drugencapsulated nanoparticles (FA-DOX-NPs and FA-PTX-NPs) as targeted chemotherapeutic agents were prepared by adding FA-Py into the systems during the emulsion process. 41 Drug-encapsulated nanoparticles (DOX-NPs and PTX-NPs) were prepared as control groups.…”

Recent advances in the synthesis and applications of macrocyclic arenes

“…112 121 also showed great affinity towards biologically relevant molecules G18-19 and biomarkers G20 with K a higher than 10 5 M À1 in water. 113 Biphen[n]arenes also had electron-rich cavities and their recognition ability toward cationic guests has been wellstudied by Li's group (Fig. 49).…”

“…112 121 also showed great affinity towards biologically relevant molecules G18-19 and biomarkers G20 with K a higher than 10 5 M −1 in water. 113…”

Ultrastable and Versatile Layer‐by‐Layer Coating Based on Kinetically Trapped Host–Guest Complexation for Mesoporous Silica Nanoparticles

“…[12,[15][16][17][18][19][20][21] Supramolecular strategy has been widely used to construct biomaterials for therapeutic or bioimaging purpose. [22][23][24][25][26][27][28][29][30][31] One key challenge for supramolecular strategy is the stability under PAA via ester and amide linkers to yield PAA-CB [6] and PAA-CPMA, respectively (Figure 1b). MSN was functionalized by CPMA-moiety with GSH-cleavable disulfide linkers.…”