<b>The 24‐hour rhythm of oxytocin and Β‐endorphin secretion in human pregnancy</b>

Lindow, Stephen W.; Newham, A. P.; Hendricks, M.S.; Thompson, J. W.; Spuy, Zephne van der

doi:10.1046/j.1365-2265.1996.8290840.x

Cited by 43 publications

(35 citation statements)

References 10 publications

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“…In contrast to Bakker et al, in primipare late term women, we have found that labor duration and active phase length of labor is shorter in the evening group than in the morning group. Our results can be explained by circadian rhythm of oxytocin concentration that was documanted by human and animal studies [10][11][12][13][14][15]. Oxytocin concentrations and myometrial oxytocin receptors increase during evening and night time with a decreased estradiol/progesterone ratio.…”

Section: Discussionmentioning

confidence: 94%

When Should the Labor Induction be Started For Late-term Pregnancies, in the Morning or in the Evening?

Kokanali¹,

Cavkaytar²,

Topçu³

et al. 2016

Ann Clin Anal Med

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ÖzetGiriş: Intravenöz oksitosin infüzyonu ile doğum indüksiyonu sabah ya da akşam başlatılan geç-term gebeliklerin sonuçlarını incelemek. Gereç ve Yöntem: Sefalik prezantasyonda tekil gebeliğe sahip, gebelik yaşı 41 0/7 haftadan 41 6/7 haftaya kadar olan 266 tane gebe bu retrospektif çalışmaya katılmıştır. İntravenöz oksiosin ile doğum indüksiyonları sabah saatlerinde (08.00-12.00) ya da akşam saatlerinde (16.00-20.00) başlatılmıştır. Doğum sonuçları ve gece saatlerindeki (20.00-08.00) doğumlar kaydedilmiştir. Bulgular: Primipar gebelerde, doğum eylemi süresi, doğum eyleminin aktif faz uzunluğu akşam grubunda sabah grubuna göre anlamlı olarak daha kısaydı. Multipar gebelerde, gece saatlerinde doğum oranı akşam grubunda sabah grubuna göre anlamlı derecede daha fazla idi. Ayrıca gece saatlerinde doğum, yenidoğan yoğun bakım ünitesine başvurmak için anlamlı bir risk faktörü olarak bulundu. Tartışma: İntravenöz oksitosin infüzyonu ile akşam başlatılan doğum indük-siyonu, primipar gebelerde doğum eylemi süresini kısaltırken multipar gebelerde kısaltmaz. Gece saatlerindeki doğum kötü perinatal sonuç için risk faktörü olabilir. Doğum indüksiyonu planlanırken, parite, indüksiyon başlama zamanı ve tahmini doğum saati olası kötü neonatal sonuçları azaltmak için dikkate alınmalıdır.Anahtar Kelimeler Doğum İndüksiyonu; Oksitosin; Sabah; Akşam Abstract Aim: We aimed to investigate the labor outcomes of late-term pregnancies underwent intravenous oxytocin induction starting in the morning compared with starting in the evening. Material and Method: 266 women with a singleton pregnancy in cephalic presentation, at gestational age of 41 0/7 through 41 6/7 weeks were enrolled in this retrospective study. Labor inductions with intravenous oxytocin were started in the morning hours (08.00-12.00) or in the evening hours (16.00-20.00). Labor outcomes and night-time (20.00-08.00) deliveries were recorded. Results: In primiparae group, labor duration and active phase length of labor were significantly shorter in the evening group than in the morning group. In multiparae women, the ratio of nighttime delivery was significantly higher in evening group as compared to morning group. And also night-time delivery was found as a significant risk factor for neonatal intensive care unit admission. Discussion: Induction of labour with intravenous oxytocin starting in the evening shortens labor duration in primiparae women, but not in multiparae women. Night-time delivery may be a risk for poor perinatal outcome. As the labor induction is planned, parity, start time of induction and estimated delivery time should be taken into account to reduce the risk of poor neonatal outcome in late-term pregnancies.

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Section: Discussionmentioning

confidence: 94%

When Should the Labor Induction be Started For Late-term Pregnancies, in the Morning or in the Evening?

Kokanali¹,

Cavkaytar²,

Topçu³

et al. 2016

Ann Clin Anal Med

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“…This finding may relate to the possible influence of endogenous analgesic agents, which have a diurnal acrophase, which is particularly evident in β-endorphin, adrenocorticotropic hormone and cortisol (Allolio et al, 1990;Lindow et al, 1996). Furthermore, it is also plausible that this nocturnal acrophase of labour pain may be related to the inhibition of melatonin secretion following the sleep deprivation commonly associated with artificial light stimulation (photo-inhibition) (LeGates et al, 2012).…”

Section: Discussionmentioning

confidence: 98%

The influence of women’s attachment style on the chronobiology of labour pain, analgesic consumption and pharmacological effect

Costa-Martins

Pereira

Martins

et al. 2014

Chronobiology International

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Circadian variation in biological rhythms has been identified as affecting both labour pain and the pharmacological properties of analgesics. In the context of pain, there is also a growing body of evidence suggesting the importance of adult attachment. The purpose of this study was to examine whether labour pain, analgesic consumption and pharmacological effect are significantly affected by the time of day, and to analyse whether this circadian variation is influenced by women's attachment style. This prospective observational study included a sample of 81 pregnant women receiving patientcontrolled epidural analgesia (PCEA). Attachment was assessed with the Adult Attachment ScaleRevised (AAS-R). The perceived intensity of labour pain in the early stage of labour (3 cm of cervical dilatation and before the administration of PCEA) was measured using a visual analogue scale (VAS).Pain was also indirectly assessed by measuring the consumption of anaesthetics. The latency period and the duration of effect were recorded for a chronopharmacology characterisation. Pain, as assessed with the VAS, was significantly higher in the night-time group than in the daytime group. An insecure attachment style was significantly associated with greater labour pain at 3 cm of cervical dilatation (p < 0.001) and before the beginning of analgesia (p < 0.001) as well as with higher analgesic consumption and lower pharmacological efficacy (p < 0.05). The time of day was significantly associated with the pharmacological effect: the latency period was longer at night, and the duration of the pharmacological effect was longer during the daytime. The interaction between time of day and attachment style was not significant for any of the study variables. Our results provide evidence of the importance of circadian variation in studying labour pain and the pharmacological effect of labour analgesia involving epidural blockage with a PCEA regimen. Moreover, although there was no evidence that attachment style influenced the circadian variation, these data emphasise that insecure attachment patterns are a risk factor for greater labour pain and analgesic consumption, which should be considered in pain management approaches.

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“…Neurohumoral changes justify the lower intensity of matutinal and evening pain, since there is an abundance of central anti-nociceptive neurotransmitters: endorphins, enkephalins, and noradrenaline, during the day (light phase). Besides the nocturnal increase in melatonin, serotonin, and acetylcholine (anti-nociceptive), a drastic reduction in the levels of endorphins, corticosteroids, as well as the elevation of pro-nociceptive mediators (histamine, PG, oxytocin, cytokines) are also seen [47][48][49] .…”

Section: Chronobiology Of Dystocia -Circadian Variation 1) Painmentioning

confidence: 99%

“…However, pain perception is subjective, individual, and non-transferable. Unlike the matutinal and afternoon periods, labor pain is more severe at night due to neurohumoral changes, nocturnal acrophase of pro-nociceptive mediators (histamine, prostaglandins, oxytocin) associated with exhaustion or sleep deprivation of the parturient 7,8,12,13,47 . In the evolutionary point of view, a lower pain threshold at night has contributed for labor acceleration: faster delivery is aimed at protecting the newborn of the Homo sapiens against natural predators since his nomadic dislocation from central Africa thousands of years ago.…”

Section: Chronobiology Of Dystocia -Circadian Variation 1) Painmentioning

confidence: 99%

“…The challenges of toco-anesthesia in high risk pregnancies and the safety of the maternal-fetal binomium in premature labor are faced by conventional regional and systemic pharmacological methods. In spinal blocks, some items are mandatory: six-to eight-hour fasting to prevent chemical pneumonitis due to aspiration of gastric contents; control of maternal hypotension and fetal hypoxia (acidosis) by moving the uterus to the left, volume expansion, administration of vasopressors (ephedrine, phenylephrine, metaraminol), and rapid fetal extraction after uterotomy (UD interval, uterotomy-delivery, lower than three minutes) 24,[45][46][47][48][49][50][51][52][53][54] . The incidence of cesarean section at the Maternidade-Escola J Cicco (UFRN-SUS) is higher than 40%, i.e., lower than the 70% incidence in private hospitals (Natal, RN, Brazil).…”

Section: Cesarian or Cesarean Sectionmentioning

confidence: 99%

See 1 more Smart Citation

O tempo e a anestesia obstétrica: da cosmologia caótica à cronobiologia

Vale¹,

Vale²,

Cruz³

2009

Rev. Bras. Anestesiol.

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CONTENTS: Chronobiological analysis of the main events in the obstetric pathophysiology of Mulier sapiens: I) Embryogenesisrisk of teratogenesis; II) From prematurity to post-didacticism: from eutocic labor to cervical cerclage; III) Night and labor: higher incidence of nocturnal labor (physiological facilitation) and daylight cesarean section (choice of the obstetrician); IV) The moon and labor -non-conclusive results; V)

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The 24‐hour rhythm of oxytocin and Β‐endorphin secretion in human pregnancy

Abstract: Reciprocal 24-hour rhythms were demonstrated between oxytocin and beta-endorphin; however, it is not clear whether this relationship is causal.

Cited by 43 publications

References 10 publications

When Should the Labor Induction be Started For Late-term Pregnancies, in the Morning or in the Evening?

When Should the Labor Induction be Started For Late-term Pregnancies, in the Morning or in the Evening?

The influence of women’s attachment style on the chronobiology of labour pain, analgesic consumption and pharmacological effect

O tempo e a anestesia obstétrica: da cosmologia caótica à cronobiologia

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