<b>UiO-68-ol</b> NMOF-Based Fluorescent Sensor for Selective Detection of HClO and Its Application in Bioimaging

Li, Yanan; Song, Yang; Li, Qian-Ying; Ma, Jian‐Ping; Zhang, Shaojun; Dong, Yu‐Bin

doi:10.1021/acs.inorgchem.7b02012

Cited by 54 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of metal ions can form the hexameric cluster that links most Zr MOFs, and so it is likely that doping of metals such lanthanides for MRI, for example into existing structures will be possible. The compatibility of Zr MOFs with biological entities suggests further bioapplications will also be possible, for example, the intracellular sensing of HClO by a redox-active UiO-68 derivative [144].…”

Section: Discussionmentioning

confidence: 99%

Application of zirconium MOFs in drug delivery and biomedicine

Lázaro

Forgan

2019

Coordination Chemistry Reviews

552

176

View full text Add to dashboard Cite

Nanoparticulate metal-organic frameworks (MOFs) have the requisite high storage capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for application as nanoscale drug delivery devices (DDSs). Zirconium MOFs in particular combine optimal stability towards hydrolysis and postsynthetic modification with low toxicity, and so are particularly suited for biological applications. This review covers the use of Zr MOFs as DDSs with focus on the different physical properties that makes them attractive for use. The various methods for modifying the surfaces of Zr MOFs are described with pertinent examples of the resulting enhancements in aqueous stability, colloidal dispersion, and stimuli-responsive drug release. The in vitro and in vivo application of Zr MOFs for photodynamic therapy and drug delivery are discussed with respect to the structural features of the MOFs and their surface functionality, and perspectives on their future applications and analogous hafnium MOFs are given.

show abstract

Section: Discussionmentioning

confidence: 99%

Application of zirconium MOFs in drug delivery and biomedicine

Lázaro

Forgan

2019

Coordination Chemistry Reviews

552

176

View full text Add to dashboard Cite

show abstract

“…Nanoscale MOFs − can be prepared from the linear dicarboxylate ligand 4,4′-(9,10-anthracenediyl)dibenzoic acid (H 2 DCDPA) and ZrCl 4 . These MOFs may also exhibit two-photon-excited fluorescence.…”

mentioning

confidence: 99%

Nanoscale Metal–Organic Frameworks and Metal–Organic Layers with Two-Photon-Excited Fluorescence

Wang

et al. 2020

Inorg. Chem.

View full text Add to dashboard Cite

Metal–organic frameworks (MOFs) based on 9,10-diphenylanthracene-derived ligands had been reported to exhibit upconverted fluorescence through triplet–triplet annihilation. We found that zirconium MOFs based on 9,10-diphenylanthracene can also give upconverted fluorescence via two-photon absorption without adding a triplet photosensitizer when a femtosecond pulsed laser is used as the excitation source. By tuning the synthetic condition, we obtained nanoscale MOFs of UiO structure in both octahedral and hexagonal nanoplate shapes, as well as a hexagonal nanoplate of MOFs of hcp-UiO structure and two-dimensional metal–organic layers. All of them, as well as a homogeneous solution of the 9,10-diphenylanthracene ligand, exhibit upconverted fluorescence upon excitation using a laser pulse of 60 fs with a pulse energy of ∼1.1 × 106 nJ/cm2 (unfocused). Moreover, we observed different emission spectra by two-photon excitation compared to those by one-photon excitation, which indicates access to a unique initial excited state via two-photon excitation. This phenomenon is not observed for a homogeneous solution of the ligand. These nanoscale MOFs may find application in two-photon fluorescence imaging.

show abstract

“…A low limit of detection (LOD) of ClO – was obtained to be 37 nM, which owned a superior performance to most fluorescent probes for the ClO – detection (Table S3). ,,− The concentration of ClO – could be detected immediately after adding Eu-BDC-NH 2 /DPA and stirring for 5 s, so the detection of ClO – is achieved within 20 s.…”

Section: Resultsmentioning

confidence: 99%

Dual-Ligand Lanthanide Metal–Organic Framework for Sensitive Ratiometric Fluorescence Detection of Hypochlorous Acid

2021

View full text Add to dashboard Cite

Sensitivity, selectivity, visible detection, and rapid response are the main concerns for an analytical method. Herein, we reported a metal–organic framework (MOF)-based ratiometric fluorescence detection strategy for hypochlorous acid (HClO). The MOF was prepared with dual ligands, 2-aminoterephthalic acid (BDC-NH2) and dipicolinic acid (DPA) and Eu3+ ions as a metal node, denoted as Eu-BDC-NH2/DPA. The dual-ligand strategy realized the dual emission for ratiometric sensing and visual detection, adjusted the size and morphology of MOFs to obtain a good dispersion for a rapid response, and provided an amino group for the special recognition of HClO. Thus, the MOF exhibited a dual emission derived from BDC–NH2 and Eu3+ ions at 433 and 621 nm, respectively, under a single excitation at 270 nm. A hydrogen bond forms between an −NH2 group and HClO to weaken the blue fluorescence at 433 nm, while the antenna effect emission from Eu3+ ions kept stable, so ratiometric sensing was realized with an easy-to-differentiate color change for visible detection. The ratiometric sensing showed a self-calibration effect and reduced the background. Thus, the high sensitivity, visual detection, low detection limit (37 nM), and short response time (within 20 s) for the detection of HClO were realized with the MOF as a probe. The analysis of real samples demonstrated the practical application of the MOF for HClO. The introduction of mixed ligands is an effective strategy to regulate the emission behaviors of MOFs for the improved analytical performance.

show abstract

UiO-68-ol NMOF-Based Fluorescent Sensor for Selective Detection of HClO and Its Application in Bioimaging

Cited by 54 publications

References 28 publications

Application of zirconium MOFs in drug delivery and biomedicine

Application of zirconium MOFs in drug delivery and biomedicine

Nanoscale Metal–Organic Frameworks and Metal–Organic Layers with Two-Photon-Excited Fluorescence

Dual-Ligand Lanthanide Metal–Organic Framework for Sensitive Ratiometric Fluorescence Detection of Hypochlorous Acid

Contact Info

Product

Resources

About