B Vitamins: Functions and Uses in Medicine

Hanna, Mary; Jaqua, Ecler; Nguyen, Van Long; Clay, Jeremy

doi:10.7812/tpp/21.204

Cited by 70 publications

(46 citation statements)

References 26 publications

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“…B vitamins are critical cofactors for axonal transport, the synthesis of neurotransmitters, and many cellular metabolic pathways. Thus, guidelines for nutritional replacement should be given to those who consume LCD [ 19 ]. Importantly, mean intakes of fat-soluble vitamins (A, E, K) did not change during our intervention.…”

Section: Discussionmentioning

confidence: 99%

The Impact of a Low-Carbohydrate Diet on Micronutrient Intake and Status in Adolescents with Type 1 Diabetes

et al. 2023

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Objective: The aim of this study was to evaluate the macronutrient and micronutrient intake and status in youth with type 1 diabetes mellitus (T1DM) following the consumption of a low-carbohydrate diet (LCD). Research Methods and Procedures: In a prospective intervention clinical trial, adolescents with T1DM using a continuous glucose monitoring device were enrolled. Following a cooking workshop, each participant received a personalized diet regime based on LCD (50–80 g carbohydrate/day). A Food Frequency Questionnaire was administered, and laboratory tests were taken before and 6 months following the intervention. Twenty participants were enrolled. Results: The median age was 17 years (15; 19), and the median diabetes duration was 10 years (8; 12). During the six-months intervention, carbohydrate intake decreased from 266 g (204; 316) to 87 g (68; 95) (p = 0.004). Energy intake, the energy percent from ultra-processed food, and fiber intake decreased (p = 0.001, p = 0.024, and p < 0.0001, respectively). These changes were accompanied by declines in BMI z-score (p = 0.019) and waist-circumference percentile (p = 0.007). Improvement was observed in the median HbA1c from 8.1% (7.5; 9.4) to 7.7% (6.9; 8.2) (p = 0.021). Significant declines below the DRI were shown in median intake levels of iron, calcium, vitamin B1, and folate. Conclusions: The LCD lowered ultra-processed food consumption, BMI z-scores and the indices of central obesity. However, LCDs require close nutritional monitoring due to the possibility of nutrient deficiencies.

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Section: Discussionmentioning

confidence: 99%

The Impact of a Low-Carbohydrate Diet on Micronutrient Intake and Status in Adolescents with Type 1 Diabetes

et al. 2023

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“…Vitamin B, also known as B complex vitamins, comprise eight water-soluble vitamins mostly present in dairy products, legumes, and animal proteins. 66 Several neurological illnesses have been linked to VB deficiency. Additionally, methyl group donation necessary for the production of proteins, lipids, nucleic acids, neurotransmitters, and hormones depends on the VB.…”

Section: Vitamin Bmentioning

confidence: 99%

The role and impact of abnormal vitamin levels in autism spectrum disorders

Cui,

Zhai,

Wang

et al. 2024

Food Funct.

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“…As a part of the coenzyme thiamine pyrophosphate, B1 is responsible for the generation of nerve impulses and the synthesis of neurotransmitters, nucleic acids, fatty acids, steroids, and complex carbohydrates. B1 deficiency causes neurological damage leading to the production of free radicals, increased oxidative stress, peripheral axonal damage, improper myelin production, and glutamate-mediated excitotoxicity [6]. B1 was reported low in most (85%) patients with acute nutritional axonal neuropathy (ANAN) [7 ▪ ].…”

Section: B Vitaminsmentioning

confidence: 99%

Vitamins in neuropathy: pathophysiological and therapeutic roles

Chen,

Song

2023

Current Opinion in Neurology

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Purpose of review Vitamin deficiency is a risk factor in the development of peripheral neuropathy, which leads to complex and severe diseases. This review provides an update overview of the literature on the roles of vitamins in peripheral neuropathy, highlighting their pathophysiological and therapeutic roles. Recent findings The importance and clinical manifestations and implications of the vitamins and vitamin deficiencies are further demonstrated in peripheral neuropathy and the associated diseases. Vitamin deficiency is common in various severe and complex diseases such as diabetes, chemotherapy, acute nutritional axonal neuropathy, dermatitis, complex regional pain syndrome, postherpetic neuralgia, carpal tunnel syndrome, and so forth and some rare clinical case reports. There is evidence that deficiencies of almost all vitamins are associated with diabetic neuropathy. Vitamin supplementation may serve as an effective therapeutic strategy. Summary The vitamins play critical roles in maintaining physiological functions, and vitamin deficiencies cause peripheral neuropathy with various severe and complex diseases. The therapeutic benefits of vitamins and further understanding of the mechanisms for vitamin treatment effects should be emphasized and highlighted. More clinical trials are needed to establish optimal treatment strategies for vitamins in the various neuropathies. A large range of people/patients screening for vitamin deficiencies may be considered in order to provide early diagnosis and timely medical assistance.

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B Vitamins: Functions and Uses in Medicine

Cited by 70 publications

References 26 publications

The Impact of a Low-Carbohydrate Diet on Micronutrient Intake and Status in Adolescents with Type 1 Diabetes

The Impact of a Low-Carbohydrate Diet on Micronutrient Intake and Status in Adolescents with Type 1 Diabetes

The role and impact of abnormal vitamin levels in autism spectrum disorders

Vitamins in neuropathy: pathophysiological and therapeutic roles

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