B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study

Moore, Katie; Hughes, Catherine F; Hoey, Leane; Ward, Mary; Cunningham, Conal; Molloy, Anne M.; Strain, JJ; McCarroll, Kevin; Casey, Miriam; Tracey, Fergal; Laird, Éamon; O’Kane, Maurice; McNulty, Helene

doi:10.1016/j.jamda.2018.11.031

Cited by 50 publications

(53 citation statements)

References 33 publications

(40 reference statements)

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“…Vitamin B6 supplementation improved MDD-symptoms in an aged cohort and vitamin B6 levels generally correlated with MDD severity (Moore et al, 2019). Furthermore, lower vitamin B6 intake correlated with disease severity in female MDD-patients (Kafeshani et al, 2019).…”

Section: Vitamins and Their Role In Depression Vitamin B6 Is An Essenmentioning

confidence: 83%

The Way to a Human’s Brain Goes Through Their Stomach: Dietary Factors in Major Depressive Disorder

Aly

Engmann

2020

Front. Neurosci.

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Globally, more than 250 million people are affected by depression (major depressive disorder; MDD), a serious and debilitating mental disorder. Currently available treatment options can have substantial side effects and take weeks to be fully effective. Therefore, it is important to find safe alternatives, which act more rapidly and in a larger number of patients. While much research on MDD focuses on chronic stress as a main risk factor, we here make a point of exploring dietary factors as a somewhat overlooked, yet highly promising approach towards novel antidepressant pathways. Deficiencies in various groups of nutrients often occur in patients with mental disorders. These include vitamins, especially members of the B-complex (B6, B9, B12). Moreover, an imbalance of fatty acids, such as omega-3 and omega-6, or an insufficient supply with minerals, including magnesium and zinc, are related to MDD. While some of them are relevant for the synthesis of monoamines, others play a crucial role in inflammation, neuroprotection and the synthesis of growth factors. Evidence suggests that when deficiencies return to normal, changes in mood and behavior can be, at least in some cases, achieved. Furthermore, supplementation with dietary factors (so called “nutraceuticals”) may improve MDD symptoms even in the absence of a deficiency. Non-vital dietary factors may affect MDD symptoms as well. For instance, the most commonly consumed psychostimulant caffeine may improve behavioral and molecular markers of MDD. The molecular structure of most dietary factors is well known. Hence, dietary factors may provide important molecular tools to study and potentially help treat MDD symptoms. Within this review, we will discuss the role of dietary factors in MDD risk and symptomology, and critically discuss how they might serve as auxiliary treatments or preventative options for MDD.

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Section: Vitamins and Their Role In Depression Vitamin B6 Is An Essenmentioning

confidence: 83%

The Way to a Human’s Brain Goes Through Their Stomach: Dietary Factors in Major Depressive Disorder

Aly

Engmann

2020

Front. Neurosci.

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“…However, long-term and extensive pharmacotherapy are almost always associated with the extent of undesirable effects on the patient like the risk of major adverse cardiovascular events, decline in cognitive functioning over time, behavioral changes including but not limited to sexual problems, and feeling of "emotional numbness." The B vitamins are crucial particulates of the 1-carbon metabolism wherein 5-methyltetrahydrofolate and methylcobalamin help convert homocysteine to methionine, which in turn forms S-adenosylmethionine (SAM), which is the essential methyl donor required for the production of monoamine neurotransmitters, phospholipids, and nucleotides [21].…”

Section: Pathophysiology Of Depressionmentioning

confidence: 99%

Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression

Sangle¹,

Sandhu²,

Aftab³

et al. 2020

Cureus

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Depression is a common mental health condition occurring across all ages, genders, and populations and is almost always multifaceted. It can manifest as a form of metabolic disorder, endocrine disorder, cardiovascular diseases, inflammatory disorders, deficiencies, or neurodegenerative disorders. Although there have been various treatment options available for the treatment of depression, it is still a sizable global health concern requiring more attention. This review article was produced by researching data and studies to prove a relationship between Vitamin B12 and depression. Numerous studies were reviewed, and based on these studies, it was concluded that supplementation of Vitamin B12 early enough can delay the onset of depression and improve the effect of anti-depressants when used in conjunction with Vitamin B12. Although other vitamins like Vitamin B6 and folate are known to have an impact on depression, we have primarily focused on Vitamin B12 in an attempt to offer the providers a foundation to address this concern with their patients prone to depression or have had a major depressive episode in their life.

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“…2019) and were associated with lower biomarker status of folate, vitamin B6 and riboflavin, which were associated with an increased risk of depression (Moore et al . 2019). The determinants of vitamin D status in ageing were also previously reported in the TUDA cohort (McCarroll et al .…”

Section: The Valid Projectmentioning

confidence: 99%

Phenyl‐γ‐valerolactones and healthy ageing: Linking dietary factors, nutrient biomarkers, metabolic status and inflammation with cognition in older adults (the VALID project)

et al. 2020

Self Cite

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Populations globally are ageing, leading to increased prevalence of cognitive dysfunction and dementia. Certain dietary patterns and/or nutritional components may have beneficial effects in helping to prevent or delay the onset of cognitive dysfunction in older adults. Flavan‐3‐ols, a complex subgroup of polyphenols (including catechins and proanthocyanins) which are abundant in foods such as tea, cocoa, grapes, nuts and berries, are almost exclusively metabolised by colonic bacteria to form phenolic acids and phenyl‐γ‐valerolactones (PVLs). PVLs, now thought to exert the anti‐inflammatory and neuroprotective effects originally attributed to flavan‐3‐ols, are relatively stable in plasma and may thus provide reliable biomarkers of dietary exposure to flavan‐3‐ols. In the VALID project (a transnational collaboration involving partners in the UK, Ireland and Italy), we aim to validate plasma PVLs as robust biomarkers of catechin/proanthocyanidin‐rich foods and demonstrate their association with cognitive function in older adults. We will utilise existing data and perform new analysis of samples from the Trinity‐Ulster and Department of Agriculture (TUDA) cohort, a study of 5186 older adults providing comprehensive data on a range of relevant variables, including nutrient biomarkers, inflammatory markers, clinical variables, socio‐economic factors and cognitive measures. In addition, we will access samples from TUDA 5+, a follow‐up study of 1000 participants from the original TUDA cohort resampled 5–7 years after their initial investigation, enabling an assessment of cognitive decline. This project aims to validate PVLs as robust biomarkers of dietary polyphenol intake and determine the potential role of catechin/proanthocyanidin‐rich foods in preserving better cognitive heath in ageing.

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B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study

Abstract: This study draws on data from over 5000 European adults of 60+ years and shows that better folate and related B-vitamin status may have a positive impact on mental health in older adults.

Cited by 50 publications

References 33 publications

The Way to a Human’s Brain Goes Through Their Stomach: Dietary Factors in Major Depressive Disorder

The Way to a Human’s Brain Goes Through Their Stomach: Dietary Factors in Major Depressive Disorder

Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depression

Phenyl‐γ‐valerolactones and healthy ageing: Linking dietary factors, nutrient biomarkers, metabolic status and inflammation with cognition in older adults (the VALID project)

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