B27 Disease versus B27 Disease

Linssen, A.

doi:10.3109/03009749009097070

Cited by 45 publications

(25 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With respect to clinical manifestations, HLA-B27+ patients more frequently suffered from acute anterior uveitis than B27- patients [76]. Observations were conformed in some smaller studies [77,78]. …”

Section: Literature Review On Prevalence and Incidence Spamentioning

confidence: 80%

Epidemiology of Spondyloarthritis

Stolwijk

Boonen

Tubergen

et al. 2012

Rheumatic Disease Clinics of North America

204

125

View full text Add to dashboard Cite

Synopsis Spondyloarthritis (SpA) represents a group of interrelated diseases with common clinical features and a close association with HLA-B27. Figures on the incidence and prevalence of diseases vary highly dependent on methodological differences between studies, the case definition used to classify disease and on the prevalence of HLA-B27 in the population studied. When summarizing the available literature, incidence rates of SpA are mainly based on the ESSG criteria and range between 0.48 and 63/100.000 while prevalence rates vary between 0.01 and 2.5%. For ankylosing spondylitis (AS), the most widely recognized representative of the SpA group of diseases, incidence rates of 0.44-7.3/100.000 and prevalence rates of 0.007-1.7% have been described in studies that were based on the (modified) New York criteria to classify cases. The incidence of psoriatic arthritis (PsA) varied from 3.6 up to 23.1/100.000 in different studies and prevalence between <0.1% and 0.4%, using a variety of classification criteria. The incidence of ReA has been estimated between 0.6 up to 28/100.000 in studies based on different source populations and different case definitions. The newly proposed criteria for axial SpA and peripheral SpA present an attractive new approach to facilitate classification of the SpA into two main subtypes and the axial SpA criteria allow earlier detection of patents with inflammatory back pain. It should be emphasized that these criteria were developed for use in a (specialized) clinical setting and not for large epidemiological studies.

show abstract

Section: Literature Review On Prevalence and Incidence Spamentioning

confidence: 80%

Epidemiology of Spondyloarthritis

Stolwijk

Boonen

Tubergen

et al. 2012

Rheumatic Disease Clinics of North America

204

125

View full text Add to dashboard Cite

show abstract

“…Although a satisfactory de®nition is still lacking for PsA, in particular for PsSpA, in the present report we have recruited only those cases ful®ll-ing the criteria given by the European Spondyloarthropathy Study Group [5] in order to standardize our observations and to make possible comparisons with other past or future reports. Most studies of gender-related clinical dierences in SpA have been carried out in ankylosing spondylitis (AS) [2,13], in which men tend to show more pronounced radiological changes and demonstrate radiological sacroiliitis earlier than women. Although axial disease is more severe in men with AS, the overall pattern of the SpA is similar in the two sexes [2,3,13].…”

Section: Discussionmentioning

confidence: 99%

“…Most studies of gender-related clinical dierences in SpA have been carried out in ankylosing spondylitis (AS) [2,13], in which men tend to show more pronounced radiological changes and demonstrate radiological sacroiliitis earlier than women. Although axial disease is more severe in men with AS, the overall pattern of the SpA is similar in the two sexes [2,3,13]. Furthermore, in AS spinal symptoms, chest expansion, peripheral arthritis and extra-articular features do not dier signi®cantly between the sexes [13].…”

Section: Discussionmentioning

confidence: 99%

“…Although the HLA-B27 antigen is the strongest genetic risk factor for SpA, it is unclear whether these gender-related dierences regarding the sex distribution of these conditions are due entirely to the presence of this genetic marker [2,3]. On the other hand, disease expression in SpA may dier in men and women, although the ®ndings of several studies are con¯icting, and no consistent picture has yet emerged [3,4].…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Comparative analysis of psoriatic spondyloarthropathy between men and women

Queiró

Sarasqueta²,

et al. 2001

Rheumatology International

View full text Add to dashboard Cite

This study analyzed gender-related differences in a cohort of patients with psoriatic spondyloarthropathy (SpA) We performed a retrospective cross-sectional study of 100 patients (mean age 48 +/- 14 years; 63 men, 37 women), diagnosed as having psoriatic SpA on the basis of ESSG criteria. All patients were studied according to a standard protocol, and HLA-B27 and Cw status were analyzed in the study population and their frequencies compared to that of 177 healthy blood donors. The clinical features of PsSpA were compared between men and women by univariate analyses. Twenty-three patients showed isolated axial disease (M:F ratio 3.6:1), 36 had polyaxial disease (M:F ratio 1:1), and 41 showed oligoaxial pattern (M:F ratio 1.7:1). HLA-B27 was correlated with male sex (P=0.002) and isolated axial disease (P=0.016). Univariate analysis showed female sex to be correlated with lower complement levels (P < 0.05), erosive disease (P = 0.05), higher swelling joint count (P = 0.002), and higher scores on the Health Assessment Questionnaire-Specific for SpA (P < 0.05). The HLA-B27 antigen seems to be a defined genetic risk factor only in men with psoriatic SpA. The extent of the spondylitic process is quite similar between the two, although women show poorer functional performance and more aggressive peripheral disease.

show abstract

“…The preponderance of AS in men (about 75%) is a general feature in SpA. [5][6][7] Various hypotheses and theories have been proposed to explain sexual dimorphism, and particularly male hormone testosterone, for SpA in humans, but so far there is no straightforward explanation. [8][9][10][11] In this work we have tested the role of male hormone testosterone on the animal model ANKENT.…”

mentioning

confidence: 99%