Bacillus amyloliquefaciens SC06 alleviates the oxidative stress of IPEC-1 via modulating Nrf2/Keap1 signaling pathway and decreasing ROS production

Wang, Yang; Wu, Yanping; Wang, Yibing; Fu, Aikun; Gong, Li; Li, Weifen; Li, Yali

doi:10.1007/s00253-016-8032-4

Cited by 133 publications

(114 citation statements)

References 55 publications

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“…Consistent with this, research in humans have shown an increased erythrocyte SOD and GPx activities as well as total antioxidant status in type 2 diabetic patients receiving yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 [57]. Furthermore, our previous in vitro research also implied that Bacillus amyloliquefaciens SC06 elevated CAT and GST gene expressions and the CAT activity in intestinal porcine epithelial cells-1 (IPEC-1) [7]. …”

Section: Modes Of Action Of Probiotic Bacteria In Antioxidationsupporting

confidence: 52%

“…According to their findings, treatment with MIYAIRI 588 elevated hepatic antioxidant enzyme activities in (CDAA)-defined-diet-induced rats via the activation of Nrf2 expressions [65]. Additionally, recent evidence obtained by our research group also demonstrated that probiotic Bacillus amyloliquefaciens SC06 ameliorated the H 2 O 2 -induced IPEC-1 oxidative stress by decreasing ROS levels and regulating Nrf2 expressions [7] (Table 1). …”

Section: Modes Of Action Of Probiotic Bacteria In Antioxidationmentioning

confidence: 98%

“…Recently, Gómez-Guzmán and colleagues have suggested that probiotics Lactobacillus fermentum CECT5716 and Lactobacillus coryniformis CECT5711 (K8) plus Lactobacillus gasseri CECT5714 (LC9) (1:1) were able to decrease NOX activity and mRNA expressions of NOX-1 as well as NOX-4 in spontaneously hypertensive rats [99]. The oxidative stress of H 2 O 2 -induced IPEC-1 was also shown as decreased NOX activity and p47 phox expression by Bacillus amyloliquefaciens SC06 treatment [7]. …”

Section: Modes Of Action Of Probiotic Bacteria In Antioxidationmentioning

confidence: 99%

“…Probiotics refer to live nonpathogenic microorganisms, which, when administered in adequate amounts, confer microbial balance, particularly in the gastrointestinal tract [4]. Evidence has showed that probiotic bacteria present significant antioxidant abilities both in vivo and in vitro [5,6,7,8]. Hence, with the increasing popularity of probiotic bacteria, we set out the antioxidant properties of probiotic bacteria and underscore their mode of action in this review.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Properties of Probiotic Bacteria

et al. 2017

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Oxidative stress defines a condition in which the prooxidant–antioxidant balance in the cell is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells’ viability. Probiotics have been known for many beneficial health effects, and the consumption of probiotics alone or in food shows that strain-specific probiotics can present antioxidant activity and reduce damages caused by oxidation. However, the oxidation-resistant ability of probiotics, especially the underling mechanisms, is not properly understood. In this view, there is interest to figure out the antioxidant property of probiotics and summarize the mode of action of probiotic bacteria in antioxidation. Therefore, in the present paper, the antioxidant mechanisms of probiotics have been reviewed in terms of their ability to improve the antioxidant system and their ability to decrease radical generation. Since in recent years, oxidative stress has been associated with an altered gut microbiota, the effects of probiotics on intestinal flora composition are also elaborated.

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Section: Modes Of Action Of Probiotic Bacteria In Antioxidationsupporting

confidence: 52%

Section: Modes Of Action Of Probiotic Bacteria In Antioxidationmentioning

confidence: 98%

Section: Modes Of Action Of Probiotic Bacteria In Antioxidationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant Properties of Probiotic Bacteria

et al. 2017

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“…This in turn triggers Nrf2 translocation to regulate expression of cellular antioxidant enzymes, including SOD and HO-1. Bacillus amyloliquefaciens SC06 has also been reported to increase the level of CAT and activate the Nrf2/Keap1 signaling pathway to boost cellular antioxidant status [41]. Further studies are required to confirm the involvement of Nrf2/Keap1 signaling in L. plantarum K2-and K6-induced effects.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Lactobacillus plantarum Strains on Non-Alcoholic Fatty Liver Disease in High Fat/High Fructose Diet-Fed Rats

et al. 2020

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Emerging evidence suggests that probiotics are beneficial in non-alcoholic fatty liver disease (NAFLD). This study aimed to explore the effects of two Lactobacillus plantarum strains, ATG-K2 and ATG-K6 (isolated from Korean fermented cabbage), in a rat model of high fat/high fructose (HF/HF) diet-induced NAFLD. Rats with NAFLD were randomized into four groups (HF/HF diet control, (HC); HF/HF diet with silymarin, (PC); HF/HF diet with ATG-K2, (K2); and HF/HF diet with ATG-K6, (K6)) with healthy rats on a normal diet serving as the negative control. After treatment, histopathological and biochemical analyses of the blood and liver tissue were conducted. In addition, fecal microbiota was analyzed using the MiSeq platform. Compared with HC rats, K2 and K6 rats experienced significantly lower body weight gain, displayed decreased hepatic lipid accumulation, had lower serum levels of aspartate aminotransferase and alanine aminotransferase, and showed increased antioxidant enzyme activities. Moreover, de novo lipogenesis-related genes were downregulated following K2 and K6 administration. The fecal microbiota of K2 and K6 rats contained a higher proportion of Bacteriodetes and a lower proportion of Fimicutes than that of HC rats. Taken together, our results suggest that L. plantarum strains ATG-K2 and ATG-K6 are potential therapeutic agents for NAFLD.Nutrients 2020, 12, 542 2 of 16 of the transcription factors, such as sterol regulatory element binding protein 1c (SREBP-1c) and CCAAT/enhancer-binding protein alpha (C/EBPα), which in turn regulate the expression of hepatic gluconeogenesis and DNL genes [6]. It follows that fructose intake increases liver gluconeogenesis and DNL and elevates blood glucose and TG levels in humans [8,9] Another cause of NAFLD is oxidative stress. Fat deposition occurring in the liver results in lipid peroxidation, and it promotes a variety of responses such as inflammation and fibrosis. Thus, antioxidants (e.g., silymarin, vitamin E) are proposed as candidates for NAFLD treatment [10,11]; however, there are no standard pharmacological therapeutic agents for NAFLD yet. Recently, emerging evidence suggests that the gut-liver axis is strongly related to NAFLD. There are several reports published clinical trials applying probiotics on NAFLD patients [12]. Lactobacillus bulgaricus and Streptococcus thermophiles treatment improved liver aminotransferases levels in adult NAFLD patients [13]. In addition, probiotic capsules containing Lactobacillus acidophilus, Bifidobacterium lactis, Bifidobacterium bifidum, and Lactobacillus rhamnosus, as a supplement also decreased liver aminotransferases levels in obese children with NAFLD [14]. These results indicate that the intake of certain probiotics has a beneficial effect on NAFLD.Lactobacillus plantarum, which plays a key role in the production of various fermented foods, is one of the most important species of lactic acid bacteria (LAB). L. plantarum is found in diverse environments, such as the soil and the human gut, and is considered a potential pro...

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