Bacillus Calmette-Guerin lymphadenitis: A 6-year experience in two Saudi hospitals

Bukhari, Elham E.; Alzahrani, Mohammed; Alsubaie, Sarah; Alrabiaah, Abdulkarim; Alzamil, Fahad

doi:10.4103/0377-4929.97869

Cited by 29 publications

(43 citation statements)

References 4 publications

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“…The site of vaccine injection is often the deltoid muscle of the left arm, and the lymphadenitis most commonly involves the left axillary lymph node, followed by the left supraclavicular lymph nodes. Less frequently, both the left axillary and left supraclavicular lymph nodes are involved [95].…”

Section: Lymphadenitismentioning

confidence: 99%

An approach to local immunotoxicity induced by adjuvanted vaccines

Batista-Duharte¹,

Portuondo

Carlos

et al. 2013

International Immunopharmacology

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Section: Lymphadenitismentioning

confidence: 99%

An approach to local immunotoxicity induced by adjuvanted vaccines

Batista-Duharte¹,

Portuondo

Carlos

et al. 2013

International Immunopharmacology

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“…Few examples of case reports are by Elyamany et al (2013), Baslaim et al (2013) and AlMaghrabi et al (2006). Experiences of BCG lymphadenitis (Bukhari et al, 2012), Castleman's disease (Al-Amri et al, 2010) and Kikuchi-Fujimoto disease (Al-Maghrabi and Kanaan, 2005) have been shared by researchers of KSA. A large series of 452 cervical lymph node biopsies from Eastern KSA has also been recently reported (AlTawfiq and Raslan, 2012).…”

Section: Introductionmentioning

confidence: 99%

Pattern of Lymph Node Pathology in Western Saudi Arabia

Albasri

El-Siddig²,

Hussainy³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: This study aimed to characterize the histopathological pattern of lymph node pathology among Saudi patients and to highlight the age and gender variations of these lesions as base line data. Materials and Methods: We retrospectively analyzed the data from lymph node biopsy specimens received at the Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia from January 2006 to December 2013. Results: Of the 289 lymph node biopsy specimens received, 154 (53.3%) were from males and 135 (46.7%) from females giving a male: female ratio of 1.14:1. Age of the patients ranged from 2.5 to 96 years with a mean age 33.9 years. The commonest lymph node group affected was the cervical (30.4%) followed by axillary (9.7%) and inguinal (8.7%). Malignant lymphoma [71 Hodgkin's disease (HD), 57 non Hodgkin's lymphoma (NHL)] 128 (44.3%), reactive hyperplasia 68 (23.5%), and tuberculosis 41 (14.2%) were the common causes of lymph node enlargement. While HD, reactive hyperplasia and tuberculosis were commonest in young adult patients (10-29 years old) and rare above the age of 50 years; NHL was the predominant cause of lymph node enlargement above 50 years. Conclusions: Lymph node biopsy plays an important role in establishing the cause of lymphadenopathy. Among the biopsied nodes, lymphomas were the most common (44.3%) followed by non-specific reactive hyperplasia (23.5%) and tuberculous lymphadenitis (14.2%).

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“…Resistance to INH was documented in two of our isolates compared to 75% in the Saudi Arabian study [2]. We followed protocol of 2HRZEO, 7 HREO and found good results [1].…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…Local and regional complications (0.4-1/1000 vaccinees) develop irrespective of immune-competence status while distant/disseminated BCG disease is generally associated with well-defined immune-deficiencies [1,2]. An increase in the number of BCG-associated suppurative lymphadenitis has been reported in many countries in recent years [2][3][4][5]. Inherited disorders of INF γ /Interleukin-12 (INF γ /IL-12) axis have been increasingly reported in association with disseminated BCG disease [6,7], now known as Mendelian Susceptibility to Mycobacterial Diseases (MSMD).…”

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confidence: 99%

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Clinical profile and outcome of clinical BCG disease in infants

et al. 2014

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Objective: To describe the clinical profile, immunological status and outcome of BCG disease in infants. Methods: All infants with a diagnosis of BCG disease in a period of 17 months were followed up. Results: Among 25 infants with BCG disease; 19 had local/ regional involvement and 6 had suspected or confirmed distant/disseminated disease, Mean (range) age of presentation was 3.6 (1.5-9) months. Two of 6 infants with disseminated disease required second-line anti-tubercular treatment. One infant with confirmed disseminated disease had INF γ R1 receptor deficiency. There was no mortality. Conclusion: Most infants with BCG-related disease have local or regional disease.

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Bacillus Calmette-Guerin lymphadenitis: A 6-year experience in two Saudi hospitals

Abstract: In light of the findings of this study, it would be advisable to administer the BCG vaccine in Saudi Arabia at a time later than at birth, as the younger children are commonly affected.

Cited by 29 publications

References 4 publications

An approach to local immunotoxicity induced by adjuvanted vaccines

An approach to local immunotoxicity induced by adjuvanted vaccines

Pattern of Lymph Node Pathology in Western Saudi Arabia

Clinical profile and outcome of clinical BCG disease in infants

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