Bacillus coagulans SCC-19 maintains intestinal health in cadmium-exposed common carp (Cyprinus carpio L.) by strengthening the gut barriers, relieving oxidative stress and modulating the intestinal microflora

Chang, Xulu; Kang, Meiru; Shen, Yifeng; Yun, Lili; Yang, Guokun; Zhu, Lei; Meng, Xiaolin; Zhang, Jianxin; Su, Xi

doi:10.1016/j.ecoenv.2021.112977

Cited by 34 publications

(10 citation statements)

References 47 publications

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“…However, this normal fluctuation of gut microbiota does not affect the execution of complex intestinal functions ( 47 , 48 ). However, strong stimulus such as various gastrointestinal diseases, antibiotics, heavy metal and microplastics could cause significant variation in gut microbial diversity and composition, causing gut microbial dysbiosis ( 49 – 51 ). Increasing investigations showed that the occurrence of diarrhea is often accompanied by significant changes in the gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Dynamic changes of gut fungal community in horse at different health states

Lan

Li²,

Yu³

et al. 2022

Front. Vet. Sci.

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Accumulating studies indicated that gut microbial changes played key roles in the progression of multiple diseases, which seriously threaten the host health. Gut microbial dysbiosis is closely associated with the development of diarrhea, but gut microbial composition and variability in diarrheic horses have not been well characterized. Here, we investigated gut fungal compositions and changes in healthy and diarrheic horses using amplicon sequencing. Results indicated that the alpha and beta diversities of gut fungal community in diarrheal horses changed significantly, accompanied by distinct changes in taxonomic compositions. The types of main fungal phyla (Neocallimastigomycota, Ascomycota, and Basidiomycota) in healthy and diarrheal horses were same but different in relative abundances. However, the species and abundances of dominant fungal genera in diarrheal horses changed significantly compared with healthy horses. Results of Metastats analysis indicated that all differential fungal phyla (Blastocladiomycota, Kickxellomycota, Rozellomycota, Ascomycota, Basidiomycota, Chytridiomycota, Mortierellomycota, Neocallimastigomycota, Glomeromycota, and Olpidiomycota) showed a decreasing trend during diarrhea. Moreover, a total of 175 differential fungal genera were identified for the gut fungal community between healthy and diarrheal horses, where 4 fungal genera increased significantly, 171 bacterial genera decreased dramatically during diarrhea. Among these decreased bacteria, 74 fungal genera even completely disappeared from the intestine. Moreover, this is the first comparative analysis of equine gut fungal community in different health states, which is beneficial to understand the important role of gut fungal community in equine health.

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Section: Discussionmentioning

confidence: 99%

Dynamic changes of gut fungal community in horse at different health states

Lan

Li²,

Yu³

et al. 2022

Front. Vet. Sci.

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“…Another study found that Bacteroides abundance increased following cadmium exposure. [24]. However, this study indicated that supplementing probiotics such as Bacillus coagulans can alleviate cadmium toxicity and relieve intestinal barrier damage resulted cadmium exposure.…”

Section: Applications Of Metagenomics In Studying Gastrointestinal Mi...mentioning

confidence: 76%

“…Furthermore, Meng and others study found out that the gut microbiome communities associated with lipid metabolism and immunity were disturbed due to waterborne chronic copper exposure [24]. The expression of five genes related to lipid metabolism in common carp's liver was investigated using 18s mRNA primers and the results revealed suppressed expression of lipogenic enzymes.…”

Section: Applications Of Metagenomics In Studying Gastrointestinal Mi...mentioning

confidence: 99%

The Impacts of Heavy Metals on the Gut Microbiome in Common Carp (Cyprinus Carpio)

Shametov

2022

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Pollution of freshwaters with heavy metals has become an acute problem in many countries including Kazakhstan, and industrial progress is the primary source of toxic heavy metals. Since gut microbe communities play a significant role in fishes' homeostasis, immune regulation, metabolism, and disease resistance, it is crucial to understand how heavy metals affect fish's gastrointestinal microbiome diversity. Applications of metagenomics using the 16S rDNA gene's hypervariable regions allow researchers to sequence the gastrointestinal microbiota's genome and identify the diversity of microorganisms, including those that cannot be cultured with traditional microbiological methods. Common carp (Cyprinus carpio) is resistant to highly polluted freshwaters with heavy metals and considered a bioindicator of freshwater pollution. Thus, this paper aims to overview heavy metals' influence on the gastrointestinal microbiome diversity in common carp. Future directions are also discussed to enhance our understanding about the relationships between different environmental factors and gut microbiome diversity of wild fish. Further, it is crucial to understand how each bacterium would help common carp resist heavy metal toxicity.

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“…Gut microbial diversity and abundance change dynamically within certain limits and affect by age, diet, and environment, but these normal changes cannot damage intestinal functions ( 33 , 34 ). However, some intense stimuli and diseases such as heavy metals, antibiotics, and gastrointestinal diseases may destroy ecological balance and induce gut microbial dysbiosis ( 35 – 37 ). Li et al revealed reduced alpha diversity of gut microbiota in giraffes during diarrhea ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Gut Microbiota Between Healthy and Diarrheic Horses

Lan

Zhang

et al. 2022

Front. Vet. Sci.

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Increasing evidence reveals the importance of gut microbiota in animals for regulating intestinal homeostasis, metabolism, and host health. The gut microbial community has been reported to be closely related to many diseases, but information regarding diarrheic influence on gut microbiota in horses remains scarce. This study investigated and compared gut microbial changes in horses during diarrhea. The results showed that the alpha diversity of gut microbiota in diarrheic horses decreased observably, accompanied by obvious shifts in taxonomic compositions. The dominant bacterial phyla (Firmicutes, Bacteroidetes, Spirochaetes, and Kiritimatiellaeota) and genera (uncultured_bacterium_f_Lachnospiraceae, uncultured_bacterium_f_p-251-o5, Lachnospiraceae_AC2044_group, and Treponema_2) in the healthy and diarrheic horses were same regardless of health status but different in abundances. Compared with the healthy horses, the relative abundances of Planctomycetes, Tenericutes, Firmicutes, Patescibacteria, and Proteobacteria in the diarrheic horses were observably decreased, whereas Bacteroidetes, Verrucomicrobia, and Fibrobacteres were dramatically increased. Moreover, diarrhea also resulted in a significant reduction in the proportions of 31 genera and a significant increase in the proportions of 14 genera. Taken together, this study demonstrated that the gut bacterial diversity and abundance of horses changed significantly during diarrhea. Additionally, these findings also demonstrated that the dysbiosis of gut microbiota may be an important driving factor of diarrhea in horses.

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Bacillus coagulans SCC-19 maintains intestinal health in cadmium-exposed common carp (Cyprinus carpio L.) by strengthening the gut barriers, relieving oxidative stress and modulating the intestinal microflora

Cited by 34 publications

References 47 publications

Dynamic changes of gut fungal community in horse at different health states

Dynamic changes of gut fungal community in horse at different health states

The Impacts of Heavy Metals on the Gut Microbiome in Common Carp (Cyprinus Carpio)

Comparative Analysis of Gut Microbiota Between Healthy and Diarrheic Horses

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