Back Cover: An Enzymatically Gated Catalytic Hairpin Assembly Delivered by Lipid Nanoparticles for the Tumor‐Specific Activation of Signal Amplification in miRNA Imaging (Angew. Chem. Int. Ed. 51/2022)

Liu, Qing; Huang, Yuanyu; Li, Zhengping; Li, Lele; Zhao, Yuliang; Li, Mengyuan

doi:10.1002/anie.202217291

Cited by 47 publications

(17 citation statements)

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“…[28]; 18 from ref. [29]; This study provides P7 to P11 with excellent toughness and ductility. c Recycle of the polymers completed through two cycles: Cycle 1 via hydrolysis, esterification, and polymerization; Cycle 2 via methanolysis and polycondensation.…”

Section: Resultsmentioning

confidence: 91%

Chemically Recyclable Polyethylene‐like Sulfur‐Containing Plastics from Sustainable Feedstocks

et al. 2023

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The green revolution in plastics should be accelerated due to growing sustainability concerns. Here, we develop a series of chemically recyclable polymers from the first reported cascade polymerization of H2O, COS, and diacrylates. In addition to abundant feedstocks, the method is efficient and air‐tolerant, uses common organic bases as catalysts, and yields polymers with high molecular weights under mild conditions. Such polymers, structurally like polyethylene with low‐density in‐chain polar groups, manifest impressive toughness and ductility comparable to high‐density polyethylene. The in‐chain ester group acts as a breaking point, enabling these polymers to undergo chemical recycling through two loops. The structures and properties of these polymers also have an immeasurably expanded range owing to the versatility of our method. The readily available raw materials, facile synthesis, and high performance make these polymers promising prospects as sustainable materials in practice.

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Section: Resultsmentioning

confidence: 91%

Chemically Recyclable Polyethylene‐like Sulfur‐Containing Plastics from Sustainable Feedstocks

et al. 2023

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“…In addition to CaB, they also constructed an enzyme-regulated amplification strategy using the AP site-specific cleavage of APE1 as a molecular switch coupled with CHA signal amplification (Figure 1C-ii). 43 In this work, tumor-cell-specific miRNA amplified imaging in vivo with enhanced spatial accuracy was achieved. Wang's group 44 also used a similar strategy to achieve precise and amplified imaging of miR-21 in mice.…”

Section: Molecular Switchesmentioning

confidence: 98%

Nucleic acid sensors in vivo: challenges and opportunities

Liu

Xiong

Rong

et al. 2023

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Nucleic acid biosensors, integrated with functional nucleic acids, have drawn extensive attention for diverse biomedical applications. In particular, many nucleic acid probes have been developed for biosensing and imaging of tumor‐associated species, including pH, small molecules, RNAs, metal ions, proteins, and cells. Despite the progress made, these sensors are mainly performed at the level of test tube assays or live cells for disease diagnosis and pathological studies. In recent years, increasing research works are pushing the limit of nucleic acid sensors in preclinical applications and imaging‐guided therapy. However, the applicability of current nucleic acid sensors in vivo is largely hindered by the complexity of living animals. Herein, we review recent advances in the design and applications of nucleic acid biosensors in vivo, in which the key factors for the fabrication of eligible sensors are highlighted. Additionally, given the inherent shortcomings of nucleic acid, we will also describe the challenges of the current in vivo nucleic acid biosensors and some new strategies that may significantly accelerate the development of biosensors.

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“…As a classical enzyme-free nucleic acid circuit amplication method, catalytic hairpin assembly (CHA) [19][20][21] achieves cyclic amplication of the target through toehold-mediated strand displacement [22][23][24] with simplicity and versatility, [25][26][27][28][29] which is one of the best candidates to achieve sensitive detection and versatility of APE1. Nevertheless, traditional CHA reactions relied on random collisions of reactants in a homogeneous solution with low collision efficiency and long reaction time, resulting in a low reaction rate and nonspecic background leakage, which limit further exploration and application of CHA.…”

Section: Introductionmentioning

confidence: 99%

Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells

et al. 2023

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Back Cover: An Enzymatically Gated Catalytic Hairpin Assembly Delivered by Lipid Nanoparticles for the Tumor‐Specific Activation of Signal Amplification in miRNA Imaging (Angew. Chem. Int. Ed. 51/2022)

Cited by 47 publications

References 0 publications

Chemically Recyclable Polyethylene‐like Sulfur‐Containing Plastics from Sustainable Feedstocks

Chemically Recyclable Polyethylene‐like Sulfur‐Containing Plastics from Sustainable Feedstocks

Nucleic acid sensors in vivo: challenges and opportunities

Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells

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