Background Comparison of Typical Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Japanese Patients

Ueta, Takashi; Obata, Ryo; Inoue, Yoshio; Iriyama, Aya; Takahashi, Hidenori; Yamaguchi, Takuhiro; Tamaki, Yasuhiro; Yanagi, Yasuo

doi:10.1016/j.ophtha.2009.06.013

Cited by 80 publications

(62 citation statements)

References 45 publications

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“…A history of CSC was more frequent in the PCV group than in the tAMD group, as shown in our previous study 13 (P ¼ 0.0286, by chi square test and post hoc Marascuilo procedure).…”

Section: Resultssupporting

confidence: 81%

“…13 The evaluation of fundus findings also indicated that a history of CSC was more common in patients with PCV than in control subjects.…”

Section: Discussionmentioning

confidence: 95%

“…The background data of patients with exudative AMD (ie, either tAMD or PCV) in our previous study 13 was used for comparison with the enrolled control subjects. In this study, we gathered background data for control subjects who were both older than 50 years and without exudative AMD.…”

Section: Participantsmentioning

confidence: 99%

“…Background data of subjects in the control group was collected using the same questionnaire as that used in our previous study, 13 as well as through the patients' medical records. A history of CSC was the primary concern in the present study; however, significant confounders such as a history of systemic steroid use, hypertension, and smoking were also considered.…”

Section: Data Collectionmentioning

confidence: 99%

“…10,11 In contrast, PCV and tAMD have genotypic similarities at the AMD-associated loci. 12 In our previous study, 13 we compared background factors between patients with tAMD and those with PCV. Although tAMD and PCV were similar in most of these factors, we observed that the history of central serous chorioretinopathy (CSC) was more frequent in patients with PCV than in those with tAMD.…”

Section: Introductionmentioning

confidence: 99%

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Polypoidal choroidal vasculopathy and history of central serous chorioretinopathy

Toyama

Ohtomo

Noda

et al. 2014

Eye

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Purpose To evaluate the possible causative role of central serous chorioretinopathy (CSC) in the development of exudative age-related macular degeneration (AMD). Methods In a cross-sectional study at an institutional setting, 150 control subjects who had senile cataract or nasolacrimal duct stenosis and who were older than 50 years were enrolled. The background data for 89 patients with typical AMD (tAMD) and 138 patients with polypoidal choroidal vasculopathy (PCV) were used for comparison. Their medical records were taken for history of CSC, hypertension, systemic steroid use, and smoking. The fundus was also evaluated for signs of atrophic retinal pigment epithelial (RPE) tract and for focal photocoagulation scars in the macula. Results After adjusting for age, gender, and history of hypertension, systemic steroid use, and smoking, history of CSC was significantly more frequent (Po0.0001) in patients with PCV (15 patients, 10.9%) compared with patients with tAMD (2 patients, 2.2%) or control subjects (0 patients). On fundoscopy, an atrophic RPE tract (seven patients) or a focal photocoagulation scar (one patient) was observed only in patients with PCV (eight patients, 5.8%), and the frequency was statistically significant compared with that with tAMD (P ¼ 0.0143) or control subjects (P ¼ 0.0143). The laterality of CSC and AMD involved the same eye in 9 of 10 patients among those who had unilateral AMD and a reported unilateral CSC history. Conclusion A history of CSC may be a predisposing factor for the development of PCV in the Japanese population.

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“…A history of CSC was more frequent in the PCV group than in the tAMD group, as shown in our previous study 13 (P ¼ 0.0286, by chi square test and post hoc Marascuilo procedure).…”

Section: Resultssupporting

confidence: 81%

“…13 The evaluation of fundus findings also indicated that a history of CSC was more common in patients with PCV than in control subjects.…”

Section: Discussionmentioning

confidence: 95%

Section: Participantsmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%