Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs &amp; PXDD/Fs) in sera of pregnant women in Accra, Ghana

Bruce-Vanderpuije, Pennante; Megson, David; Jobst, Karl J.; Jones, Gareth R.; Reiner, Eric J.; Sandau, Courtney D.; Clarke, Edith; Adu-Kumi, Sam; Gardella, Joseph A.

doi:10.1016/j.scitotenv.2019.04.060

Cited by 25 publications

(7 citation statements)

References 66 publications

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“…The total TEQs of PCDDs, PCDFs, and PCDD/Fs in maternal serum between this study and other studies globally are shown in Table 5. Mean ∑TEQ-PCDDs, ∑TEQ-PCDFs, and ∑TEQ-PCDD/Fs in the present study were higher than most background concentrations reported in the serum of pregnant women in other locations of the world (Baba et al, 2018;Bao et al, 2020;Boda et al, 2018;Bruce-Vanderpuije et al, 2019;Rodríguez Dozal S et al, 2011;Todaka et al, 2010;Yu DZ et al, 2019). ∑TEQ-PCDD/Fs in maternal serum were also compared with the biomonitoring equivalent (BE) for risk assessment.…”

Section: Discussioncontrasting

confidence: 44%

Associations between maternal serum concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and pulse pressure in early pregnancy

Liu

Cao

Xiao

et al. 2022

Preprint

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Purpose Pulse pressure (PP) is the difference between systolic blood pressure (SBP) and diastolic blood pressure (DBP), and an independent predictor of cardiovascular risk. Previous research suggests that exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) could affect blood pressure (BP). We conducted a cross-sectional study to determine the association of dioxin exposure with PP in early pregnancy. A total of 305 pregnant women in early pregnancy in Yingcheng, China, recruited from May 2018 to December 2019 were included in this study. Methods We measured 17 types of PCDD/Fs in maternal serum via high-resolution gas chromatography tandem high-resolution mass spectrometry. A generalized linear regression model was used to analyze the influencing factors of dioxin exposure and their relationships with PP. Results The levels of total PCDD/Fs (∑PCDD/Fs) ranged from 163.52 pg/g lipid to 1,513,949.52 pg/g lipid, with a mean of 10,474.22 pg/g lipid. The mean toxicity equivalent (TEQ) of total PCDD/Fs (∑TEQ-PCDD/Fs) was 42.03 pg/g lipid. The ratio of tetrachlorinated to octa-chlorinated congeners in maternal serum was enriched with an increasing number of chlorines. Pregnant women with college and above education had higher concentrations of ∑PCDD/Fs than those with education levels of junior high school and below (β = 0.34, 95% CI: 0.01, 0.67). The adjusted model for ∑TEQ-PCDD/Fs was significantly and negatively associated with PP (β=-1.79, 95% CI: -2.91, -0.68). Conclusion High levels of dioxins were found in this area, and exposure to dioxins may affect the PP of women in early pregnancy, with health risks.

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Section: Discussioncontrasting

confidence: 44%

Associations between maternal serum concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and pulse pressure in early pregnancy

Liu

Cao

Xiao

et al. 2022

Preprint

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“…There are many biomonitoring studies of dioxins, such as in human serum [36], mother serum [37], cord blood [38,39], and so on, but only a few studies focused on umbilical cord serum. Wang et al reported the mean TEQ of 13.56 pg·g −1 lipid in cord serum of pregnant women in Taiwan [12].…”

Section: Resultsmentioning

confidence: 99%

Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Umbilical Cord Serum from Pregnant Women Living Near a Chemical Plant in Tianjin, China

Liu

Xiao

et al. 2019

IJERPH

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Polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans (PCDD/Fs), and dioxin-like polychlorinated biphenyls (dl-PCBs) are bioaccumulative compounds that may affect fetal growth and infant development. The aim of this study was to determine whether the pregnant women living near a chemical plant in Tianjin had a risk of exposure to dioxins. Concentrations of PCDD/Fs and dl-PCBs in 24 umbilical cord serum samples collected from pregnant women were measured using a high-resolution gas chromatograph with a high-resolution mass spectrometer (HRGC-HRMS) and an isotopic dilution method. The levels of ∑(PCDD/Fs + dl-PCBs) were in the range 476–8307 pg·g−1 lipid, with a mean of 3037 pg·g−1. The mean World Health Organization toxicity equivalent (WHO-TEQ) for PCDD/Fs and dl-PCBs was 14.0 and 2.14 pg·g−1 lipid, respectively. The PCDD/Fs and dl-PCBs contributed 86.7% and 13.3%, respectively, to the total TEQ. The octa-CDFs and penta-CBs were predominant for the PCDD/Fs and dl-PCBs, accounting for 57.6% and 74.3%, respectively. Several PCDD/F and dl-PCB congeners were highly correlated, such as PCB 105 and PCB 118 (r = 0.982, p < 0.001). Although the results hint at decreasing trends for PCDD/F and dl-PCBs by comparison with a similar study in Tianjin, a total TEQ of 41.7% of study participants had a body burden that exceeded the biomonitoring equivalents for dioxins. It was shown that pregnant women and infants had a health risk of exposure to dioxins.

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“…Stress Ghana [126] Physical injury Brazil, Ghana, Nigeria, India [89,90,128] Excessive noise Ghana, China [130,131] Pregnancy-related issues China, Ghana [132][133][134][135][136] DNA damage China, Nigeria [137][138][139][140] Skin problems India, Brazil, Nigeria [89,90,127,129] Respiratory problems Ghana, India, Nigeria, China [89,90,113,141] Hearing problems Ghana, China, Nigeria, India [130,[142][143][144][145]…”

Section: Health Impact Country Referencementioning

confidence: 99%

Electronic Waste, an Environmental Problem Exported to Developing Countries: The GOOD, the BAD and the UGLY

et al. 2021

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Electronic waste (e-waste) is a rapidly developing environmental problem particularly for the most developed countries. There are technological solutions for processing it, but these are costly, and the cheaper option for most developed countries has been to export most of the waste to less developed countries. There are various laws and policies for regulating the processing of e-waste at different governance scales such as the international Basel Convention, the regional Bamoko Convention, and various national laws. However, many of the regulations are not fully implemented and there is substantial financial pressure to maintain the jobs created for processing e-waste. Mexico, Brazil, Ghana Nigeria, India, and China have been selected for a more detailed study of the transboundary movements of e-waste. This includes a systematic review of existing literature, the application of the Driver, Pressure, State, Impact, Response (DPSIR) framework for analysing complex problems associated with social ecological systems, and the application of the Life Cycle Assessment (LCA) for evaluating the environmental impact of electronic devices from their manufacture through to their final disposal. Japan, Italy, Switzerland, and Norway have been selected for the LCA to show how e-waste is diverted to developing countries, as there is not sufficient data available for the assessment from the selected developing countries. GOOD, BAD and UGLY outcomes have been identified from this study: the GOOD is the creation of jobs and the use of e-waste as a source of raw materials; the BAD is the exacerbation of the already poor environmental conditions in developing countries; the UGLY is the negative impact on the health of workers processing e-waste due to a wide range of toxic components in this waste. There are a number of management options that are available to reduce the impact of the BAD and the UGLY, such as adopting the concept of a circular economy, urban mining, reducing loopholes and improving existing policies and regulations, as well as reducing the disparity in income between the top and bottom of the management hierarchy for e-waste disposal. The overarching message is a request for developed countries to help developing countries in the fight against e-waste, rather than exporting their environmental problems to these poorer regions.

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Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana

Abstract: A (2019)Background levels of dioxinlike polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana. Science of The Total Environment, 673. pp. 631-642.

Cited by 25 publications

References 66 publications

Associations between maternal serum concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and pulse pressure in early pregnancy

Associations between maternal serum concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and pulse pressure in early pregnancy

Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Umbilical Cord Serum from Pregnant Women Living Near a Chemical Plant in Tianjin, China

Electronic Waste, an Environmental Problem Exported to Developing Countries: The GOOD, the BAD and the UGLY

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