Background Paper on Fat and Fatty Acid Requirements during Pregnancy and Lactation

Brenna, J. Thomas; Lapillonne, Alexandre

doi:10.1159/000228998

Cited by 94 publications

(122 citation statements)

References 220 publications

(210 reference statements)

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“…Previously we showed by 13 C labeling that ARA-PL, specifi cally as ARA-phosphatidylcholine (PC), when added to artifi cial formula is about twice as effi cacious as a substrate for supplying ARA to the brain as ARA-TAG in neonatal baboons ( 21 ). We report here a similar study in neonatal piglets using 13 C-DHA, specifi cally investigating effi cacy for supplying the gray matter of the cerebral cortex with DHA.…”

Section: Dose and Samplingmentioning

confidence: 70%

“…Group PC was orally dosed with PC- 13 C-DHA as described below. Group TAG was dosed with TAG- 13 C-DHA.…”

Section: Dose and Samplingmentioning

confidence: 99%

“…Group PC was orally dosed with PC- 13 C-DHA as described below. Group TAG was dosed with TAG- 13 C-DHA. The four smallest piglets were used as natural abundance isotopic controls and did not receive a dose but were otherwise treated identically to the other animals.…”

Section: Dose and Samplingmentioning

confidence: 99%

“…Doses were prepared by dissolving CHCl 3 solutions of PC- 13 C-DHA or TAG- 13 C-DHA in about 1 ml of refi ned olive oil and driving off the CHCl 3 by gentle heating under fl owing dry N 2 over 4 h. The resulting olive oils were carefully placed on the surface of a few milliliters of reconstituted piglet formula and sonicated until homogeneous. The resulting labeled formula was split gravimetrically into 1-2 ml aliquots and administered orally to the piglets via syringe.…”

Section: Dose and Samplingmentioning

confidence: 99%

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Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

Liu

Bartke

Daele

et al. 2014

Journal of Lipid Research

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Section: Dose and Samplingmentioning

confidence: 70%

“…Group PC was orally dosed with PC- 13 C-DHA as described below. Group TAG was dosed with TAG- 13 C-DHA.…”

Section: Dose and Samplingmentioning

confidence: 99%

Section: Dose and Samplingmentioning

confidence: 99%

Section: Dose and Samplingmentioning

confidence: 99%

See 2 more Smart Citations

Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

Liu

Bartke

Daele

et al. 2014

Journal of Lipid Research

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“…A specific functional role of DHA had been shown in the fetus and early infant neural development, which might influence neonatal viability (Cattaneo et al, 2006;Capper et al, 2007). Docosahexaenoic acid is highly concentrated in brain tissues and selectively accumulated during later stages of fetal development and infant brain growth (Brenna and Lapillonne, 2009;Hsieh and Brenna, 2009). Research suggests that DHA intake in pregnancy provides advantages to both the developing fetus and mother (Saldanha et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Plasma Fatty Acid Profile of Gestating Ewes Supplemented with Fishmeal

Chee¹

2012

American Journal of Animal and Veterinary Sciences

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Problem statement:The very long chain n-3 polyunsaturated fatty acids (>18C) cannot be adequately synthesized by ruminant tissues to meet their requirements; therefore, their concentration in body depends on the supply through feed. It may be possible to improve the essential fatty acid status of ruminant animals, during gestation by manipulating the maternal diet with fishmeal (FM). The objectives of this research were to (1) determine the effect of fishmeal supplementation on the plasma fatty acid profile of ewes during late gestation and (2) determine the status of the plasma docosahexaenoic acid (22:6n3) of lambs born to these ewes. Approach: Eight gestating ewes [RideauArcott, 97±5 kg initial body weight, 100 days of gestation] were used in a completely randomized design. Ewes were individually-housed and fed either a control diet (supplemented with soybean meal) or a fishmeal supplemented diet. Blood samples were collected via jugular venipuncture for plasma fatty acids analysis on 100, 114, 128 and 142 days of gestation after morning feeding. Blood samples from the lambs were also collected via jugular venipuncture immediately after birth and before receiving their mothers' colostrum. Plasma fatty acids were analyzed by gas-liquid chromatography.

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Effect of DHA Supplementation During Pregnancy on Maternal Depression and Neurodevelopment of Young Children

Makrides

Gibson

McPhee

et al. 2010

JAMA

487

412

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PIDEMIOLOGICAL INVESTIGAtions from the United States and Europe demonstrate that higher intakes of n-3 long-chain polyunsaturated fatty acids (LCPUFA) from fish and seafood during pregnancy are associated with a reduced risk of depressive symptoms in the postnatal period, 1 as well as improved developmental outcomes in the offspring. 2,3 Of the n-3 LCPUFA, it is hypothesized that docosahexaenoic acid (DHA) may be responsible for the observed associations based on estimates of dietary requirements during pregnancy and the results of experimental animal studies. 4 However, n-3 LCPUFA intervention trials in human pregnancy have reported mixed results and have not been conclusive largely because of methodological limitations. Studies focused on perinatal mood have had open-label designs, small sample sizes, or large attrition, and most did not analyze by intention-to-treat. 5 Similarly, trials focused on the developmental outcomes of the children have made post-See also p 1717 and Patient Page.

show abstract

Background Paper on Fat and Fatty Acid Requirements during Pregnancy and Lactation

Cited by 94 publications

References 220 publications

Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

Plasma Fatty Acid Profile of Gestating Ewes Supplemented with Fishmeal

Effect of DHA Supplementation During Pregnancy on Maternal Depression and Neurodevelopment of Young Children

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