Baclofen (Lioresal<sup>R</sup>) Intoxication Report of 4 Cases and Review of the Literature

Haubenstock, Alexander; Hrubý, K; Jäger, Ulrich; Lenz, Kurt

doi:10.3109/15563658308990050

Cited by 37 publications

(36 citation statements)

References 13 publications

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“…Since then, there have been several cases or case series involving up to 23 patients [1,7,10,11,12,13]. Presently, the rate of baclofen intoxications has increased [12,13], mainly because of its off-label use in alcohol dependent patients who much more often perform suicidal attempts [12].…”

Section: Discussionmentioning

confidence: 99%

Correlation between the single, high dose of ingested baclofen and clinical symptoms

Anand

Zając

Waldman

et al. 2017

Ann Agric Environ Med.

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Introduction and Objectives. Baclofen is a drug used mainly to treat muscle spasticity. Its overdose can lead to lifethreatening clinical symptoms, including acute respiratory failure requiring mechanical ventilation. The aim of this study was to assess the prevalence of selected clinical symptoms associated with baclofen poisoning comparing to an ingested dose. Materials and method. 60 cases of oral baclofen poisoning were analyzed. Gender, age distribution, and correlation between the dose of ingested baclofen were studied, as well as and following clinical parameters: degree of altered consciousness, heart rate, blood pressure, presence of acute respiratory failure, duration of mechanical ventilation, and presence of psychotic symptoms. Results. The study found statistically significant correlations between dosage of ingested baclofen and presence of acute respiratory failure, as well as duration of mechanical ventilation. No statistically significant correlations were found between the dose of ingested baclofen and presence of hypertension, bradycardia, acute psychotic symptoms, or level of consciousness disturbance. However, it was found that patients who suffered from hypertension, bradycardia, and altered mental status ingested a larger dose of baclofen. Conclusions. There is a statistically significant correlation between the dose of ingested baclofen and the presence of acute respiratory failure, and duration of mechanical ventilation. Patients who have taken a single dose of baclofen of 200 mg, or higher, should be managed in centres able to provide continuous monitoring of life functions. Those with a higher level of a single dose of baclofen ingestion (>500 mg), should be hospitalized in a Toxicology Unit or Intensive Care Unit able to provide airway support and mechanical ventilation.

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Section: Discussionmentioning

confidence: 99%

Correlation between the single, high dose of ingested baclofen and clinical symptoms

Anand

Zając

Waldman

et al. 2017

Ann Agric Environ Med.

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show abstract

“…Baklofen aşırı doz kullanımının nörolojik belirtileri santral sinir sistemi ve nöral aktivitede depresyon ile bağlantılıdır (12). Hastamızı yoğun bakım ünitemize kabul ettiğimizde Glasgow Koma Skoru E1M1VE, hipotonik, pupiller middilate, bilateral ışık refleksi negatif, derin tendon refleksleri alınamıyordu.…”

Section: Discussionunclassified

“…Yapılan deneysel çalışmalarda, beyin ve sinir dokusundaki baklofen düzeylerinin kandaki düzeyden daha düşük olmasına karşılık beyin ve sinir dokusundan eliminasyon hızını daha yavaş bulmuşlardır (4,12). Bu durum plazma konsantrasyonlarının toksik düzeyden, tedavi edici seviyeye inmesine rağmen santral sinir sistemi depresyonunun neden uzun sürdüğünü açıklamaktadır (4,12).…”

Section: Discussionunclassified

“…Bu durum plazma konsantrasyonlarının toksik düzeyden, tedavi edici seviyeye inmesine rağmen santral sinir sistemi depresyonunun neden uzun sürdüğünü açıklamaktadır (4,12).…”

Section: Discussionunclassified

“…Miyozis, midriyazis, ışık reaksiyonu pozitif ya da negatif saptanabilir (12). Olgumuzda yoğun bakıma kabulünde ışık reaksiyonu bilateral negatif olup izlemi sırasında bilateral pozitif olarak saptandı.…”

Section: Discussionunclassified

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Baclofen (Lioresal^R) Intoxication Report of 4 Cases and Review of the Literature

Abstract: 4 cases of baclofen intoxication were reported to the Vienna Poison Information Center during the years 1974-1982. These cases are presented and are discussed along with previously published cases of baclofen intoxication. A review of symptomatology and therapy is given.

Cited by 37 publications

References 13 publications

Correlation between the single, high dose of ingested baclofen and clinical symptoms

Correlation between the single, high dose of ingested baclofen and clinical symptoms

Baclofen Intoxication

Baclofen 1134‐47‐0

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Baclofen (LioresalR) Intoxication Report of 4 Cases and Review of the Literature

Abstract: 4 cases of baclofen intoxication were reported to the Vienna Poison Information Center during the years 1974-1982. These cases are presented and are discussed along with previously published cases of baclofen intoxication. A review of symptomatology and therapy is given.

Cited by 37 publications

References 13 publications

Correlation between the single, high dose of ingested baclofen and clinical symptoms

Correlation between the single, high dose of ingested baclofen and clinical symptoms

Baclofen Intoxication

Baclofen 1134‐47‐0

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Product

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Baclofen (Lioresal^R) Intoxication Report of 4 Cases and Review of the Literature