Bacteremia caused by VanC-type enterococci in a university hospital in Japan: a 6-year survey

Koganemaru, Hiroshi; Hitomi, Shigemi

doi:10.1007/s10156-008-0644-x

Cited by 22 publications

(20 citation statements)

References 34 publications

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“…These isolates comprise the majority of VRE bloodstream infection (BSI) isolates and are associated with significant mortality [4]. Conversely, the vanC genotype is associated with constitutive low-level vancomycin resistance and is intrinsic to Enterococcus gallinarum and Enterococcus casseliflavus [5]. Whilst these strains exhibit resistance to vancomycin, ampicillin susceptibility is typically retained [5].…”

Section: Introductionmentioning

confidence: 99%

Clinical epidemiology of vancomycin-resistant Enterococcus gallinarum and Enterococcus casseliflavus bloodstream infections

Britt

Potter

2016

Journal of Global Antimicrobial Resistance

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This study aimed to evaluate the clinical outcomes of vancomycin-resistant enterococcal bloodstream infections (VRE BSI) caused by Enterococcus gallinarum or Enterococcus casseliflavus. Variables associated with treatment failure were determined and treatment options were compared. This was a national retrospective study of hospitalised Veterans Affairs patients with non-faecium, non-faecalis VRE BSI. The primary outcome was treatment failure, defined as a composite of: (i) 30-day all-cause mortality; (ii) microbiological failure; and (iii) 30-day VRE BSI recurrence. Stepwise Poisson regression was conducted to determine variables associated with treatment failure. In total, 48 patients were included, with 29 cases (60.4%) caused by E. gallinarum and 19 cases (39.6%) caused by E. casseliflavus. Among these cases, 20 (41.7%) were treated with an anti-VRE agent (linezolid or daptomycin) and 28 (58.3%) were treated with an anti-enterococcal β-lactam. Overall, 30-day mortality was 10.4% (5/48) and composite treatment failure was 39.6% (19/48). In multivariate analysis, treatment with an anti-enterococcal β-lactam was associated with increased treatment failure in comparison with anti-VRE therapy (adjusted risk ratio = 1.73, 95% confidence interval 1.06–4.97; P = 0.031). Overall, treatment with linezolid or daptomycin for vancomycin-resistant E. gallinarum or E. casseliflavus BSI resulted in improved clinical outcomes in comparison with anti-enterococcal β-lactam treatment.

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Section: Introductionmentioning

confidence: 99%

Clinical epidemiology of vancomycin-resistant Enterococcus gallinarum and Enterococcus casseliflavus bloodstream infections

Britt

Potter

2016

Journal of Global Antimicrobial Resistance

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“…Enterococcal bacteremia associated with E. faecalis and E. faecium is generally associated with a high mortality rate. Since 1989, there have been only 56 reported cases of E. casseliflavus bacteremia [1][2][3][4]. We report a similar case in a middle-aged Caucasian female who was currently undergoing chemotherapy for adenocarcinoma of the pancreas.…”

Section: Introductionmentioning

confidence: 66%

“…Up to 17% of E. casseliflavus isolates demonstrate vancomycin resistance. E. casseliflavus has been reported as the causative agent in cases of endophthalmitis, spontaneous bacterial peritonitis, meningitis, pericarditis, thrombophlebitis and sepsis [4][5][6][7][8][9][10]. Mortality rates (1.9%) appear to be lower in those individuals who develop bacteremia from a biliary source.…”

Section: Introductionmentioning

confidence: 99%

Enterococcal Bacteremia Caused byEnterococcus casseliflavus: A Case Report

Woolery¹

2016

Clin Infect Immun

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We report a case of enterococcal bacteremia caused by Enterococcus casseliflavus in a middle-aged female with adenocarcinoma of the pancreas. This individual had undergone previous biliary tract surgery 7 months prior and was currently undergoing active chemotherapy treatment with gemcitabine. She coincidently also had a lower urinary tract infection with Escherichia coli. She was successfully treated with intravenous (IV) ceftriaxone and IV ampicillin.

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“…E. casseliflavus was identified in 4 cases and E. gallinarum in 5 cases. Among 9 cases of bacteremia caused by vanC-type, 5 cases were neutropenic and and 4 cases had biliary tract infection (15). In that period, vanC-type enterococci were responsible from 12% of all Enterococcal bacteremia.…”

Section: Discussionmentioning

confidence: 99%

Enterococcus Casseliflavus Bacteremia: A Report of Two Cases and Review of the Literature

Bilman¹,

Çiçek²

2015

Haseki

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Özet Abs tractIntrinsically vancomycin-resistant Enterococci are rarely recovered from blood culture. These microorganisms usually exist in human gastrointestinal tract. Enterococci have an important role in serious invasive infections, including nosocomial infections, endocarditis, bacteremia, urinary tract infection, and pelvic infection. The clinical importance of intrinsically vancomycin-resistant enterococci is increasing day by day, because some of them are responsible for recurrent bacteremia in humans with malignancy and receipt of transplant history. Generally, intrinsic low-level vancomycin resistance (vanC type) is observed in E. casseliflavus and E. gallinarum species. However, E. gallinarum isolates which carried both the vanC1 and vanA genes were described in two research. In our study, we reviewed the medical records of two patients with E. casseliflavus bacteremia and investigated underlying diseases or conditions. Both patients had chronic renal failure and they were being treated in the hemodialysis unit at our hospital. When reproduction was detected in their blood culture, the patients were administered combination therapy including daptomycin+imipenem and daptomycin+cefepime during bacteremia periods. The patients' condition improved within 72 hours with treatment. In conclusion, this study demonstrates that intrinsically vancomycin-resistant enterococci have the clinical significance in the treatment of in bacteremia developing on basis of a chronic illness or malignancy. (The Me di cal Bul le tin of Ha se ki 2015; 53: 175-8)

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Bacteremia caused by VanC-type enterococci in a university hospital in Japan: a 6-year survey

Cited by 22 publications

References 34 publications

Clinical epidemiology of vancomycin-resistant Enterococcus gallinarum and Enterococcus casseliflavus bloodstream infections

Clinical epidemiology of vancomycin-resistant Enterococcus gallinarum and Enterococcus casseliflavus bloodstream infections

Enterococcal Bacteremia Caused byEnterococcus casseliflavus: A Case Report

Enterococcus Casseliflavus Bacteremia: A Report of Two Cases and Review of the Literature

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