Bacteremia Due to Clostridium Difficile: Case Report and Review of the Literature

Abstract

Objective: The purpose of this study is to report a case of C. diffi cile bacteremia in a Crohn's disease patient and to review the literature on previously reported cases.Methods: Searches of MEDLINE and PubMed databases were made. Results:We report the fi rst case of C. diffi cile bacteremia in a Crohn's disease patient. There are 15 other reported cases of C. diffi cile bacteremia reported in the literature. We found that the majority of patients (10 of 15 patients) had polymicrobial bacteremia and that the overall mortality rate is signifi cant, with 6 of 15 reported patients dying. Conclusion:In conclusion, we fi nd that C. diffi cile bacteremia is associated with a signifi cant mortality rate and it would seem prudent to consider aggressive antibiotic therapy.

Clostridium difficile bacteremia: Report of two cases in French hospitals and comprehensive review of the literature

“…Indeed, monomicrobial CDB was present as frequently as CDB associated with additional pathogens to C. difficile (30/60, [50%]), which is similar to the 50% (6/12) of Lee et al series, even if it has been reported that CDB were rather polymicrobial infections probably because of the small number of cases recorded at that time [27], [43], [44], [45]. In CDB, isolates other than C. difficile are often also from the gut flora.…”

Extraintestinal Clostridium difficile Infections: A Single-Center Experience

“…Traditional factors associated with intestinal CDI, including antibiotic exposure, hospitalization, and possibly PPI use, have been described in earlier reports of extraintestinal CDI 11,12,26 and were present in our cohort. Most patients in our cohort had a diagnosis of cancer or IBD, which has been described previously.…”

“…Most patients in our cohort had a diagnosis of cancer or IBD, which has been described previously. 10,11,26 They possessed multiple risk factors for intestinal CDI, including frequent hospitalization, antimicrobial exposure, immunocompromised status, and surgical intervention.…”

Successful Treatment of Clostridium difficile Bacteremia with Aortic Mycotic Aneurysm in a Patient with Prior Endovascular Aortic Aneurysm Repair

“…Suppressive antibiotic therapy and use of rifampin need to be tailored to individual patients. The literature supports aggressive treatment of C. difficile associated mycotic aneurysms due to the high mortality rate [ 15 ].…”