Bacteremic community-acquired infections due to Klebsiella pneumoniae: clinical and microbiological presentation in New Caledonia, 2008–2013

Melot, Bénédicte; Colot, Julien; Guerrier, Gilles

doi:10.1016/j.ijid.2015.10.013

Cited by 26 publications

(17 citation statements)

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“…Twenty-two percent (22%; 94/437) of isolates cultured were ESBL-producing K. pneumoniae, whilst 21% (92/437) and 17% (73/437) were A. baumannii and P. aeruginosa [31], respectively. High rates of carbapenem-resistant A. baumannii were detected in 2004 in the Central Hospital (CH) in Noumea, (New Caledonia), and accounted for a quarter of all multi-drug resistant bacteria (24.7%; 50/202) isolated [32]. Over 4000 km away, an outbreak of carbapenem-resistant A. baumannii affecting 24 patients (19 colonised and 5 infected) occurred in the CH in Papeete, French Polynesia in the same year [33,34].…”

Section: Discussionmentioning

confidence: 99%

Bacteriology and Antimicrobial Resistance in Vanuatu: January 2017 to December 2019

et al. 2020

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The World Health Organization has identified surveillance as a key objective in the containment of antimicrobial resistance. Local antimicrobial resistance surveillance data are used to generate antibiograms to monitor resistance patterns and inform clinicians in the selection of the appropriate empiric treatment when culture results are pending, or if laboratory diagnosis is unavailable. However, producing robust bacteriology data is challenging for Pacific Island Countries and Territories with limited microbiology laboratory capacity. The aim of this study is to describe pathogen occurrence and antibiotic resistance in specimens cultured at the main referral hospital in Vanuatu. We reviewed specimen culture results for the period from January 1, 2017 to December 31, 2019. Demographic and clinical data were extracted from printed and electronic registers and described and analysed. A total of 5816 specimens were cultured, of which 21% were culture positive. Staphylococcus aureus was the predominant pathogen overall (41%), and 3% of the isolates were the methicillin-resistant Staphylococcus aureus. Escherichia coli and Klebsiella pneumoniae were the most frequently isolated gram-negative pathogens, of which 14% and 26% were extended-spectrum β-lactamase-producing, respectively. Our results suggest there is a need for other Pacific Island Countries and Territories to conduct similar studies. There are gaps in knowledge about antimicrobial resistance in Pacific Island Countries and Territories. Antibiograms based on reliable data will define and inform local and national actions for containing antimicrobial resistance. There is also a need to establish a regional surveillance network to strengthen national efforts and to link surveillance data for collaborative action against antimicrobial resistance.

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Section: Discussionmentioning

confidence: 99%

Bacteriology and Antimicrobial Resistance in Vanuatu: January 2017 to December 2019

et al. 2020

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“…It causes nosocomial and community-acquired infections, liver abscess, and urinary tract infections, mostly in patients with underlying diseases. 1 , 2 This organism is among the top three pathogens of international concern documented in the World Priority List of Antibiotic-Resistant Bacteria released by the World Health Organization (WHO) in 2018. 3 Over the past two decades, K. pneumoniae has been the second most prevalent etiological agent of community-acquired (CA) urinary tract infections (UTI).…”

Section: Introductionmentioning

confidence: 99%

<p>Characterization of Hypervirulent Extended-Spectrum β-Lactamase-Producing <em>Klebsiella pneumoniae</em> Among Urinary Tract Infections: The First Report from Iran</p>

Taraghian¹,

Esfahani²,

Moghim³

et al. 2020

IDR

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Introduction This study was conducted to identify the hypermucoviscosity, iron acquisition, and capsule serotypes of K. pneumoniae strains isolated from urinary tract infections among community-acquired patients (CA) and assess the frequency of plasmid-mediated quinolone resistance (PMQR) and extended-spectrum beta-lactamases (ESBL) genes between classic and hypervirulent strains. Materials and Methods A total of 105 K. pneumoniae were isolated from CA-UTI. Demographic data related to the underlying diseases and clinical manifestations were further collected. Antibiotic resistance pattern and molecular characterization were compared among ESBL-positive, ESBL-negative, hypervirulent, and classic isolates. Results The results revealed that 52.4% of the isolates were confirmed as ESBL producers and 11 (10.5%) were considered as hypervirulent K. pneumoniae (hvKp). Ciprofloxacin and nalidixic acid were the most inactive antibiotics with resistance rates of 68.6% and 64.8%, respectively. Molecular characterization revealed that 7.6% of all the isolates carried k1 and 66.6% carried K2 genes. The most frequent ESBL gene was bla SHV 63.8%, followed by bla TEM 59.0%, and bla CTX-M 58.1%. ESBL genes were signiﬁcantly more in hvKp than in cKp. Moreover, 61 (84.7%), 47 (65.2%), and 16 (22.2%) of isolates harbored qnrB, qnrS , and qnrA . ESBL genes were detected in all hvKps, and bla SHV was observed in 90.9% of hvKp ( P value= 0.048, 95%). Discussion This study reported the high frequency of antimicrobial and multidrug resistance among hvKp isolates. Coexistence of PMQR and ESBL genes in hvkp indicates the necessity to enhance the clinical knowledge and management of hvKp infections.

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“…So it is able to produce infection in theses organs in case of low immunity in community and health care settings. 1,2,3,4 In triple sugar iron agar gel Klebsiella produces hydrogen sulfide gas, urease and lysine decarboxylase positive. This organism shows in vitro antimicrobial activity due to following factors, like, environmental pH, stability of the drug, components of the environment, sample amount for incubation, duration of incubation as well as microorganism's metabolic activity.…”

Section: Introductionmentioning

confidence: 99%

Pattern of Antimicrobial Susceptibility of Klebsiella Pneumoniae Isolated from Urinary Samples in urinary Tract Infection in a Tertiary Care Hospital, Kishanganj, Bihar, 5 Years’ Experience

Saha¹

2019

IJCMR

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Background: Urinary tract infection is very common infection in the community and hospital and multi drug resistant klebsiella pneumoniae is noted as most alarming prevalent infecting organism worldwide. The aim was to know the pattern of susceptibility to antibiotics of klebsiella pneumoniae in urinary tract infection. Materials and methods: In this retrospective cross sectional study morning midstream urine sample of 1550 symptomatic patients was taken for culture and sensitivity. Only 208 patients' (145 females and 63 males) urine demonstrated growth of klebsiella pneumoniae susceptible to different antibiotics. Results: Out of 208 patients 145 were females (69.71%) and 63 males (30.28%). Klebsiella pneumoniae was sensitive to was highly sensitive to polymyxin (91.82%), colistin (89.42%), Imipenem (88.94%), meropenem (79.32%), ertapenem (75%), moderately sensitive to aminoglycoside group (amikacin 59.13%, gentamicin 52.40%, Netilmicin 50.96%), piperacillin-tazobactam (53.84%) mildly sensitive to tobramycin (49.51%), nitrofurantoin (48.07%), cefoperazonetazobactam (45.67%) levofloxacin (45.19%). Least sensitive drugs (below 20%) were chloramphenicol, ticarcillin, amoxicillin, amoxicillin-clavulanic acid, cefuroxime, azithromycin, aztreonam, cefoxitin. Conclusion: Since multi-drug resistant klebsiella pneumoniae become highly prevalent in the community, so prevention in the form of health education to the community as well as early detection of resistance to different antibiotics is very appropriate to prevent the spread of resistance.

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Bacteremic community-acquired infections due to Klebsiella pneumoniae: clinical and microbiological presentation in New Caledonia, 2008–2013

Abstract: K. pneumoniae is a dominant cause of severe community-acquired bacteremic infection in New Caledonia. Physicians should be aware of the poor prognosis of any patient with a bacteremic K. pneumoniae infection and should monitor patients presenting with risk factors closely.

Cited by 26 publications

References 17 publications

Bacteriology and Antimicrobial Resistance in Vanuatu: January 2017 to December 2019

Bacteriology and Antimicrobial Resistance in Vanuatu: January 2017 to December 2019

<p>Characterization of Hypervirulent Extended-Spectrum β-Lactamase-Producing <em>Klebsiella pneumoniae</em> Among Urinary Tract Infections: The First Report from Iran</p>

Pattern of Antimicrobial Susceptibility of Klebsiella Pneumoniae Isolated from Urinary Samples in urinary Tract Infection in a Tertiary Care Hospital, Kishanganj, Bihar, 5 Years’ Experience

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