2021
DOI: 10.1002/elps.202000277
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Bacteria and cancer cell pearl chain under dielectrophoresis

Abstract: In this work, we aim to observe and study the physics of bacteria and cancer cells pearl chain formation under dielectrophoresis (DEP). Experimentally, we visualized the formation of Bacillus subtilis bacterial pearl chain and human breast cancer cell (MCF-7) chain under positive and negative dielectrophoretic force, respectively. Through a simple simulation with creeping flow, AC/DC electric fields, and particle tracing modules in COMSOL, we examined the mechanism by which bacteria self-organize into a pearl … Show more

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Cited by 9 publications
(7 citation statements)
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“…Second, the addition of LiFePO 4 particles could even increase the trapping efficiency. This is because trapped particles can create additional field inhomogeneous that would increase trapping efficiency by forming so-called pearl chains . Nonetheless, the results would benefit from a further investigation of the particles and their mixture before and after the separation to show which particle sizes are retained in the channel and whether there is a cutoff diameter.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Second, the addition of LiFePO 4 particles could even increase the trapping efficiency. This is because trapped particles can create additional field inhomogeneous that would increase trapping efficiency by forming so-called pearl chains . Nonetheless, the results would benefit from a further investigation of the particles and their mixture before and after the separation to show which particle sizes are retained in the channel and whether there is a cutoff diameter.…”
Section: Resultsmentioning
confidence: 99%
“…This is because trapped particles can create additional field inhomogeneous that would increase trapping efficiency by forming so-called pearl chains. 54 Nonetheless, the results would benefit from a further investigation of the particles and their mixture before and after the separation to show which particle sizes are retained in the channel and whether there is a cutoff diameter. Also, it needs to be investigated how residuals on the particles (e.g., binder or electrolyte) or changes in particle size due to upstream processes interfere with the DEP behavior of the particles and what space-time yield this method can achieve.…”
Section: Resultsmentioning
confidence: 99%
“…Microfluidics involves the examination and control of minute quantities of fluids, typically in the microliter or nanoliter range. This field has gained significant prominence in research due to its diverse applications in areas like biotechnology, pharmaceuticals, diagnostics, lab-on-chip (LOC), separation and isolation of circulating tumor cells, sperm sorting, and bacteria or algae detection [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. The integration of microscale structures on a single chip has revolutionized research across various domains by enabling the swift manipulation, analysis, and distribution of small samples.…”
Section: Introductionmentioning
confidence: 99%
“…There are many techniques for manipulating cells, such as microfluidics [1][2][3], dielectrophoresis [4][5][6], optical tweezers [7,8], optically induced electrokinetics [9], or a combination of several techniques [10,11]. Microfluidic technique needs to design different microchannels for different experiments, which cannot be changed after fabrication.…”
Section: Introductionmentioning
confidence: 99%