Bacteria-dye combination screening: Diamine-containing BMeS-p-A dye for specific fluorescence imaging of Acinetobacter baumannii

Kang, Sangrim; Jung, Yuna; Jung, Junyang; Park, Ki-Ho; Kim, Dokyoung

doi:10.1016/j.dyepig.2020.108939

Cited by 12 publications

(6 citation statements)

References 30 publications

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“…In 2021, our group introduced a new concept, bacteria-dye combination screening (BDCS), using BMeS-p-A dye for specific fluorescence imaging of Acinetobacter baumannii . 50 As follow-up research, we have focused on the development of the BMeS-p-A library including alkylated and acylated derivatives.…”

Section: Resultsmentioning

confidence: 99%

Development of a fluorescent nanoprobe based on an amphiphilic single-benzene-based fluorophore for lipid droplet detection and its practical applications

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Development of a fluorescent nanoprobe based on an amphiphilic single-benzene-based fluorophore for lipid droplet detection and its practical applications

et al. 2022

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“…Kim et al proposed a bacterial combinatorial screening method using three fluorophores, probes 11-13 (Figure 7A) (Kang et al, 2021). The three probes have different numbers of positive charges; probe 11 is a monoamine, probe 12 is a diamine, and probe 13 is a cationic diamine.…”

Section: Interaction With Other Components In Bacterial Membranementioning

confidence: 99%

Strategies of Detecting Bacteria Using Fluorescence-Based Dyes

et al. 2021

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Identification of bacterial strains is critical for the theranostics of bacterial infections and the development of antibiotics. Many organic fluorescent probes have been developed to overcome the limitations of conventional detection methods. These probes can detect bacteria with “off-on” fluorescence change, which enables the real-time imaging and quantitative analysis of bacteria in vitro and in vivo. In this review, we outline recent advances in the development of fluorescence-based dyes capable of detecting bacteria. Detection strategies are described, including specific interactions with bacterial cell wall components, bacterial and intracellular enzyme reactions, and peptidoglycan synthesis reactions. These include theranostic probes that allow simultaneous bacterial detection and photodynamic antimicrobial effects. Some examples of other miscellaneous detections in bacteria have also been described. In addition, this review demonstrates the validation of these fluorescent probes using a variety of biological models such as gram-negative and -positive bacteria, antibiotic-resistant bacteria, infected cancer cells, tumor-bearing, and infected mice. Prospects for future research are outlined by presenting the importance of effective in vitro and in vivo detection of bacteria and development of antimicrobial agents.

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“…Hence, there is an urgent need to develop alternate rapid and accurate labelling techniques to detect and identify bacteria in clinical specimens 3 and a few studies have demonstrated the application of Gram-selective optical probes with clinical specimens. Several strategies have been used to develop Gram-specific fluorescent probes, [4][5][6][7] including the development of positively charged dyes 8 or aggregation-induced emission systems, [9][10][11][12] or the direct covalent conjugation of known fluorophores to pathogen-binding ligands. [13][14][15][16] In this exploratory study, we designed and evaluated a fluorescent probe for the rapid detection of Gram-positive bacteria in ocular specimens in comparison with the conventional Gram stain.…”

Section: Introductionmentioning

confidence: 99%

“…Several strategies have been used to develop Gram-specific fluorescent probes, [4][5][6][7] including the development of positively charged dyes 8 or aggregation-induced emission systems, [9][10][11][12] or the direct covalent conjugation of known fluorophores to pathogen-binding ligands. [13][14][15][16] In this exploratory study, we designed and evaluated a fluorescent probe for the rapid detection of Gram-positive bacteria in ocular specimens in comparison with the conventional Gram stain.…”

Section: Introductionmentioning

confidence: 99%

Rapid detection of major Gram-positive pathogens in ocular specimens using a novel fluorescent vancomycin-based probe

et al. 2022

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Bacteria-dye combination screening: Diamine-containing BMeS-p-A dye for specific fluorescence imaging of Acinetobacter baumannii

Cited by 12 publications

References 30 publications

Development of a fluorescent nanoprobe based on an amphiphilic single-benzene-based fluorophore for lipid droplet detection and its practical applications

Development of a fluorescent nanoprobe based on an amphiphilic single-benzene-based fluorophore for lipid droplet detection and its practical applications

Strategies of Detecting Bacteria Using Fluorescence-Based Dyes

Rapid detection of major Gram-positive pathogens in ocular specimens using a novel fluorescent vancomycin-based probe

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