Bacteria-Eradicating Therapy With Doxycycline in Ocular Adnexal MALT Lymphoma: A Multicenter Prospective Trial

Ferreri, Andrés J.M.; Ponzoni, Maurilio; Giusti, Massimo; Resti, Antonio Giordano; Politi, Letterio S.; Cortelazzo, Sergio; Demeter, Judit; Zallio, Francesco; Palmas, Angelo; Muti, Giuliana; Dognini, Giuseppina; Pasini, Elisa; Lettini, Antonia Anna; Sacchetti, Federico; Conciliis, Carlo de; Doglioni, Claudio; Dolcetti, Riccardo

doi:10.1093/jnci/djj373

Cited by 194 publications

(158 citation statements)

References 32 publications

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“…Micro-organisms have been implicated in the pathogenesis of MALT lymphoma arising from some locations, 16 with successful treatment by using antibiotics, most notably doxycycline for orbital MALT lymphomas. [17][18][19] However, the results are still premature to consider it as a primary modality of therapy because durable remission has only been documented in 48% in a cohort of 27 patients treated 19 and that a uniformly high response rate has not been reported by other investigators. 20 However, it is a nonmorbid treatment, and therefore an attractive initial treatment approach and can spare or delay the use of cytotoxic therapy such as RT.…”

Section: Discussionmentioning

confidence: 99%

Long‐term outcome in localized extranodal mucosa‐associated lymphoid tissue lymphomas treated with radiotherapy

Goda

Gospodarowicz

Pintilie

et al. 2010

Cancer

188

126

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BACKGROUND: This study was conducted to evaluate the long-term outcomes in patients with stage IE and IIE mucosa-associated lymphoid tissue (MALT) lymphomas treated with involved field radiotherapy (RT). METHODS: Between 1989 and 2004, 192 patients with stage I and II MALT lymphomas were treated. The report focuses on 167 patients who received RT. The median age of patients was 58 years with a female predominance (2:1). Presenting sites were as follows: orbital adnexa in 71 patients, salivary glands in 28 patients, stomach in 25 patients, thyroid in 21 patients, and other sites in 22 patients. The median dose to nonorbital sites was 30 grays (Gy) (range, 17.5-35 Gy) and was 25 Gy for the orbit (range, 25-35 Gy). The median follow-up was 7.4 years (range, 0.67-16.20 years). RESULTS: Complete response and complete response, unconfirmed (CR/CRu) was noted in 166 (99%) patients. The 10-year recurrence-free rate (RFR) was 76%, the disease-free survival (DFS) rate was 68%, the overall survival (OS) rate was 87%, and the cause-specific survival rate was 98%. According to presenting site, the 10-year RFR was 95% for thyroid, 92% for stomach, 68% for salivary glands, and 67% for orbit. Patients with thyroid and gastric MALTs had better outcome compared with patients with MALTs diagnosed at other sites (P ¼.004). Among those patients who achieved CR, 19% developed disease recurrence (n ¼ 31), chiefly in distant sites or untreated contralateral-paired organs. At the time of disease recurrence, 7 patients (23%) had transformed to diffuse large B-cell lymphoma, 2 of whom died of lymphoma. The 5-year OS rate after treatment failure was 83%. CONCLUSIONS: Patients with localized MALT lymphomas are reported to have excellent clinical outcome after moderate-dose RT, and some are likely cured. In the current study, thyroid and gastric MALTs were found to have significantly less risk of distant recurrence. Despite disease recurrence, the overall survival remains excellent in these patients. Cancer 2010;116:3815-24.

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Section: Discussionmentioning

confidence: 99%

Long‐term outcome in localized extranodal mucosa‐associated lymphoid tissue lymphomas treated with radiotherapy

Goda

Gospodarowicz

Pintilie

et al. 2010

Cancer

188

126

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“…While gastric MALT lymphomas are invariably associated with Helicobacter species, pulmonary MALT lymphoma, similarly to other non-gastric MALT lymphomas, might be associated with several infectious agents. A recent study from Italy showed that 6 of the 13 C. psittaci negative ocular MALT lymphomas also responded to antibiotic treatment, suggesting the presence of other bacteria (Ferreri et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma

Chanudet

Adam

et al. 2007

Br J Cancer

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Chlamydia pneumoniae, Chlamydia trachomatis and Chlamydia psittaci were detected at low frequencies (o20%) among 69 pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas, 30 other lymphoproliferative disorders (LPD) and 44 non-LPD. The incidence of individual Chlamydiae was generally higher in MALT lymphoma than non-LPD, although not reaching statistical significance. Mycoplasma pneumoniae DNA was not detected.

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“…119 Nearly 80% of early stage H. pylori-associated gastric MZBCLs, but also a proportion of cutaneous and ocular adnexal MZBCLs is curable by bacterial eradication alone. 62,164,165 Similarly, IFNα-2b treatment can cause regression of HCV-associated MZBCL. 166,167 In vitro culture experiments with gastric MZBCL cells have revealed that the tumor B cells do not respond to H. pylori directly, but instead depend for their survival on stimuli provided by intra-tumoral, H. pylori-specific T cells.…”

Section: Bcr Specificity Of Marginal Zone B-cell Lymphomasmentioning

confidence: 99%

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

Bende¹,

Maldegem²,

Noesel³

2009

Haematologica

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Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.Key words: B-cell non-Hodgkin's lymphoma, extranodal marginal zone B-cell lymphoma, immunoglobulin, B-cell antigen receptor, inflammation, lymphoid tissue neogenesis. Haematologica 2009;94:1109-1123. doi:10.3324/haematol.2009 This is an open-access paper. Citation: Bende RJ, van Maldegem F, and van Noesel CJM. Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B cell lymphomas. ABSTRACT Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

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Bacteria-Eradicating Therapy With Doxycycline in Ocular Adnexal MALT Lymphoma: A Multicenter Prospective Trial

Cited by 194 publications

References 32 publications

Long‐term outcome in localized extranodal mucosa‐associated lymphoid tissue lymphomas treated with radiotherapy

Long‐term outcome in localized extranodal mucosa‐associated lymphoid tissue lymphomas treated with radiotherapy

Chlamydiae and Mycoplasma infections in pulmonary MALT lymphoma

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

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