Bacteria isolated from urine and their susceptibility in elderly patients

Akpabie, A.; Prieur, B.

doi:10.1016/s0399-077x(01)00248-7

Cited by 1 publication

(2 citation statements)

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“…Infection in geriatric patients (>65 years) poses a particular problem here. Whereas in younger adults the predominant causative organism in UTI is E. coli , in geriatric patients the pathogens include E. coli among a variety of both Gram‐negative and Gram‐positive micro‐organisms (Akpabie and Prieur 2001; Shortliffe and McCue 2002; Farrell et al. 2003; Farajnia et al.…”

Section: Introductionmentioning

confidence: 99%

“…2009). Additionally, while only 2% of adults aged 18–44 have mild to moderate renal impairment, this figure rises to 12% of patients aged >65 and to nearly one‐third of patients aged >85 (Akpabie and Prieur 2001). Consequently, although nitrofurantoin is an alternative to trimethoprim as a first‐line drug (Shortliffe and McCue 2002), the contraindication of this drug in renal impairment makes it an unsuitable choice in elderly patients.…”

Section: Introductionmentioning

confidence: 99%

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Photoantimicrobials as a potential local approach to geriatric UTIs

Wainwright

Stanforth

Jones

et al. 2010

Letters in Applied Microbiology

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Aims: To test the efficacy of acceptable photoantimicrobial agents against bacterial pathogens implicated in complicated urinary tract infection (UTI) in comparison with conventionally employed antibacterials. Methods and Results: Toluidine blue (TB), methylene blue (MB), 5‐aminolaevulinic acid (ALA), trimethoprim and levofloxacin were employed in the study against the typical UTI‐implicated pathogens Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Proteus mirabilis. Standard bacterial cell culture was used to assay the activity both in the dark and under 660‐nm LED‐illuminated conditions. TB and MB were highly photoactive across the range and exhibited rapid kill rates, their effects being assayed after 20‐min illumination, rather than the 18‐h incubation employed with the other compounds. Trimethoprim was inactive against all bacteria except Pr. mirabilis, while levofloxacin maintained highly bactericidal activity throughout. ALA required high concentrations for effective action but, for porphyrin production in situ, also required an 18‐h incubation. Conclusions: TB and MB were highly and rapidly photobactericidal in comparison with the remaining agents tested. Significance and Impact of the Study: Ubiquitous catheterization of geriatric patients offers a portal for light delivery to the urinary tract. The photoantimicrobial approach thus offers considerable potential.

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