Bacterial adhesion to orthopaedic implant materials and a novel oxygen plasma modified PEEK surface

Rochford, Edward T.J.; Poulsson, Alexandra H.C.; Salavarrieta, Julián; Lezuo, Patrick; Richards, R. Geoff; Moriarty, T. Fintan

doi:10.1016/j.colsurfb.2013.09.012

Cited by 73 publications

(70 citation statements)

References 53 publications

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“…Consequently, even though the in vitro ζ‐potential for PEEK is included in Figure for reference, its in vivo value is expected to be neutral to <10 mV, similar to other untreated polymeric materials . In summary, the results of this study for surface charging, hydrophilic behavior, and associated biofilm formation are consistent with previous research involving these and similar biomaterials . They support the concept that highly hydrophilic surfaces with large negative ζ‐potentials preclude microorganism attachment.…”

Section: Discussionsupporting

confidence: 86%

“…In accordance with the Vroman Effect , the first proteins are typically those that are plentiful and small (for example, albumin, immunoglobulins, and fibrin). Then, over time, these smaller proteins are replaced by larger molecules that have a higher affinity to the particular surface . Although protein attraction and adhesion are largely concentration dependent, all are also subject to the same electrokinetic forces that affect bacteria, including ionic or electrostatic and hydrophobic‐hydrophilic interactions.…”

Section: Discussionmentioning

confidence: 99%

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Bacteriostatic behavior of surface modulated silicon nitride in comparison to polyetheretherketone and titanium

Bock

Jones

Ray

et al. 2017

J Biomedical Materials Res

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Perioperative and latent infections are leading causes of revision surgery for orthopaedic devices resulting in significant increased patient care, comorbidities, and attendant costs. Identifying biomaterial surfaces that inherently resist biofilm adhesion and bacterial expression is an important emerging strategy in addressing implant-related infections. This in vitro study was designed to compare biofilm formation on three biomaterials commonly employed in spinal fusion surgery-silicon nitride (Si N ), polyetheretherketone (PEEK), and a titanium alloy (Ti6Al4V-ELI) -using one gram-positive and one gram-negative bacterial species. Disc samples from various surface treated Si N , PEEK, and Ti6Al4V were inoculated with 10 CFU/mm Staphylococcus epidermidis (ATCC®14990™) or Escherichia coli (ATCC 25922™) and cultured in PBS, 7% glucose, and 10% human plasma for 24 and 48 h, followed by retrieval and rinsing. Vortexed solutions were diluted, plated, and incubated at 37 °C for 24 to 48 h. Colony forming units (CFU/mm ) were determined using applicable dilution factors and surface areas. A two-tailed, heteroscedastic Student's t-test (95% confidence) was used to determine statistical significance. The various Si N samples showed the most favorable bacterial resistance for both bacilli tested. The mechanisms for the bacteriostatic behavior of Si N are likely due to multivariate surface effects including submicron-topography, negative charging, and chemical interactions which form peroxynitrite (an oxidative agent). Si N is a new biomaterial with the apparent potential to inhibit biofilm formation. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1521-1534, 2017.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Bacteriostatic behavior of surface modulated silicon nitride in comparison to polyetheretherketone and titanium

Bock

Jones

Ray

et al. 2017

J Biomedical Materials Res

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“…In vitro adhesion of the bacteria to a range of orthopedic metals was measured using the preoperative contamination model of Rochford et al (27). The metals used were electropolished stainless steel (SS), standard microrough titanium-aluminum-niobium (NS), and electropolished titanium-aluminum-niobium (NE).…”

Section: Methodsmentioning

confidence: 99%

Propionibacterium acnes and Staphylococcus lugdunensis Cause Pyogenic Osteomyelitis in an Intramedullary Nail Model in Rabbits

et al. 2014

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b Propionibacterium acnes and coagulase-negative staphylococci (CoNS) are opportunistic pathogens implicated in prosthetic joint and fracture fixation device-related infections. The purpose of this study was to determine whether P. acnes and the CoNS species Staphylococcus lugdunensis, isolated from an "aseptically failed" prosthetic hip joint and a united intramedullary nail-fixed tibial fracture, respectively, could cause osteomyelitis in an established implant-related osteomyelitis model in rabbits in the absence of wear debris from the implant material. The histological features of P. acnes infection in the in vivo rabbit model were consistent with localized pyogenic osteomyelitis, and a biofilm was present on all explanted intramedullary (IM) nails. The animals displayed no outward signs of infection, such as swelling, lameness, weight loss, or elevated white blood cell count. In contrast, infection with S. lugdunensis resulted in histological features consistent with both pyogenic osteomyelitis and septic arthritis, and all S. lugdunensis-infected animals displayed weight loss and an elevated white blood cell count despite biofilm detection in only two out of six rabbits. The differences in the histological and bacteriological profiles of the two species in this rabbit model of infection are reflective of their different clinical presentations: low-grade infection in the case of P. acnes and acute infection for S. lugdunensis. These results are especially important in light of the growing recognition of chronic P. acnes biofilm infections in prosthetic joint failure and nonunion of fracture fixations, which may be currently reported as "aseptic" failure.

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“…As already mentioned, all the parameters are included in the standard ISO 25178. The correlation to the amount of cellular adhesion has already been observed for some of the parameters presented here [55][56][57][58], while for the others this correlation must be verified with experimental observations.…”

Section: Appendix Definitions Of Areal Surface Parametersmentioning

confidence: 91%

Design and characterization of textured surfaces for applications in the food industry

Lazzini¹,

Romoli²,

Blunt³

et al. 2017

Surf. Topogr.: Metrol. Prop.

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Description of two-process surface topography W Grabon and P Pawlus -A study of variations of areal parameters on machined surfaces P Pawlus, W Grabo, R Reizer et al. AbstractThe aim of this work is to design, manufacture and characterize surface morphologies on AISI 316L stainless steel produced by a custom designed laser-texturing strategy. Surface textures were characterized at a micrometric dimension in terms of areal parameters compliant with ISO 25178, and correlations between these parameters and processing parameters (e.g. laser energy dose supplied to the material, repetition rate of the laser pulses and scanning velocity) were investigated. Preliminary efforts were devoted to the research of special requirements for surface morphology that, according to the commonly accepted research on the influence of surface roughness on cellular adhesion on surfaces, should discourage the formation of biofilms. The topographical characterization of the surfaces was performed with a coherence scanning interferometer. This approach showed that increasing doses of energy to the surfaces increased the global level of roughness as well as the surface complexity. Moreover, the behavior of the parameters S pk , S vk also indicates that, due to the ablation process, an increase in the energy dose causes an average increase in the height of the highest peaks and in the depth of the deepest dales. The study of the density of peaks S pd showed that none of the surfaces analyzed here seem to perfectly match the conditions dictated by the theories on cellular adhesion to confer anti-biofouling properties. However, this result seems to be mainly due to the limits of the resolving power of coherence scanning interferometry, which does not allow the resolution of submicrometric features which could be crucial in the prevention of cellular attachment.

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Bacterial adhesion to orthopaedic implant materials and a novel oxygen plasma modified PEEK surface

Cited by 73 publications

References 53 publications

Bacteriostatic behavior of surface modulated silicon nitride in comparison to polyetheretherketone and titanium

Bacteriostatic behavior of surface modulated silicon nitride in comparison to polyetheretherketone and titanium

Propionibacterium acnes and Staphylococcus lugdunensis Cause Pyogenic Osteomyelitis in an Intramedullary Nail Model in Rabbits

Design and characterization of textured surfaces for applications in the food industry

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