Bacterial adhesion to toroidal nano-structures from poly(styrene)-block-poly(tert-butyl acrylate) diblock copolymer thin films

Li, Shuyan; Komaromy, Andras Zsigmond; Nicolau, Dan V.; Boysen, Reinhard I; Hearn, Milton T. W.

doi:10.1016/j.mee.2009.12.042

Cited by 7 publications

(5 citation statements)

References 12 publications

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Section: Introductionmentioning

confidence: 99%

“…Due to its optimal mechanical properties but frequently suboptimal cytocompatibility properties, researchers have suggested several techniques to improve polyurethane (PU) for numerous tissue engineering applications. [1][2][3][4][5][6][7][8][9] PU is hydrolytically stable, however, the presence of ether linkages in PU soft segments renders them susceptible to chemical degradation which allows for easy chemical and structural manipulation. [3][4][5] 12 Moreover, Tanzi et al 3,4 investigated the PU HNO 3 chemical degradation process and found that bond scissions were created near the interphase boundary between the hard and soft segments of the polymer thereby resulting in polymer degradation.…”

Section: Introductionmentioning

confidence: 99%

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Decreased bacteria density on nanostructured polyurethane

Yao

Webster

Hedrick

2013

J Biomedical Materials Res

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As is well known, medical device infections are a growing clinical problem with no clear solution due to previous failed attempts of using antibiotics to decrease bacteria functions for which bacteria quickly develop a resistance toward. Because of their altered surface energetics, the objective of the present in vitro study was to create nanoscale surface features on polyurethane (PU) by soaking PU films in HNO3 and to determine bacteria (specifically, S. epidermidis, E. coli, and P. mirabilis) colony forming units after 1 h. Such bacteria frequently infect numerous medical devices. Results provided the first evidence that without using antibiotics, S. epidermidis density decreased by 5 and 13 times, E. coli density decreased by 6 and 20 times, and P. mirabilis density decreased by 8 and 35 times compared to conventional PU and a tissue engineering control small intestine submucosa (SIS), respectively. Material characterization studies revealed significantly greater nanoscale roughness and hydrophobicity for the HNO3-treated nanostructured PU compared to conventional PU (albeit, still hydrophilic) which may provide a rationale for the observed decreased bacteria responses. In addition, significantly greater amounts of fibronectin adsorption from serum were measured on nanorough compared conventional PU which may explain the decreased bacteria growth. In summary, this study provides significant promise for the use of nanostructured PU to decrease bacteria functions without the use of antibiotics, clearly addressing the wide spread problem of increased medical device infections observed today.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Decreased bacteria density on nanostructured polyurethane

Yao

Webster

Hedrick

2013

J Biomedical Materials Res

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“…A first criterion for enhanced oil and water repellency or amphiphobicity is the low surface tension of the coating. The surface tensions of PtBA and PFOEMA are 31.2 and ∼7 mN/m, respectively. Increasing the presence of PFOEMA in a surface should enhance its amphiphobicity.…”

Section: Resultsmentioning

confidence: 97%

Simultaneous Coating of Silica Particles by Two Diblock Copolymers

Xiong

Liu

Duncan

2012

ACS Appl. Mater. Interfaces

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Silica particles have been coated by two diblock copolymers, P1 and P2, through a one-pot reaction, and the resultant particles were characterized. The P1 and P2 used were synthesized by anionic polymerization and denote PIPSMA-b-PFOEMA and PIPSMA-b-PtBA, respectively. Here PIPSMA, PFOEMA, and PtBA correspond individually to poly[3-(triisopropyloxysilyl)propyl methacrylate], poly(perfluorooctylethyl methacrylate), and poly(tert-butyl acrylate). Catalyzed by HCl, the PIPSMA blocks of P1 and P2 co-condensed onto the surface of the same silica particles, exposing the PtBA and PFOEMA blocks. The relative amounts of grafted P1 and P2 could be tuned by changing the P1 to P2 weight ratio and were quantified by thermogravimetric analysis. The vertical segregation of the PFOEMA and PtBA chains could also be adjusted. Casting a dispersion of the coated particles in a solvent selective for either PFOEMA or PtBA onto glass plates or silicon wafers yielded films consisting of bumpy silica particles whose surfaces were enriched by the polymer that was soluble in the casting solvent. Particulate coatings with tunable surface wetting properties were obtained by changing either the proportion of grafted P1 and P2 or the casting solvent for coated silica. When a silica dispersion in perfluoromethylcychohexane (C(7)F(14)) was cast, films of coated silica that had P1 weight fractions of 25, 50, and 75% were all superhydrophobic because the particle surfaces were enriched by PFOEMA, which was selectively soluble in C(7)F(14).

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“…Hydrophilicity is an important factor for the bacterial adhesion and biocompatibility of materials [32,33]. As shown in figure 7, the silver-containing polymers had a lower water contact angle compared with control polyether-urethane.…”

Section: Water Contact Anglementioning

confidence: 99%

Development of bacterially resistant polyurethane for coating medical devices

et al. 2012

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Polyurethanes have been widely used in medicine for coating and packaging implantable and other medical devices. Polyether-urethanes, in particular, have superior mechanical properties and are biocompatible, but in common with other medical materials they are susceptible to microbial film formation. In this study, polyether-urethane was end-capped with silver lactate and silver sulfadiazine functional groups to produce a bacterially resistant polymer without sacrificing the useful mechanical properties of the polyether-polyurethane. The silver ions were covalently incorporated into the polymer during chain extension of the prepolymer. The functionalized polymers were structurally characterized by light scattering, electron microscopy, NMR, FTIR and Raman spectroscopy. Mechanical properties, hydrophilicity, in vitro stability and antibacterial action of polymers were also investigated. Results indicate that both silver salts were successfully incorporated into the polymer structure without significant effect on mechanical properties, whilst conferring acceptable bacterial resistance.

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Bacterial adhesion to toroidal nano-structures from poly(styrene)-block-poly(tert-butyl acrylate) diblock copolymer thin films

Cited by 7 publications

References 12 publications

Decreased bacteria density on nanostructured polyurethane

Decreased bacteria density on nanostructured polyurethane

Simultaneous Coating of Silica Particles by Two Diblock Copolymers

Development of bacterially resistant polyurethane for coating medical devices

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