Bacterial cellulose and its potential for biomedical applications

Wahid, Fazli; Huang, Liurong; Zhao, Xueqing; Li, Wenchao; Wang, Yun-Ya; Jia, Shiru; Zhong, Cheng

doi:10.1016/j.biotechadv.2021.107856

Cited by 96 publications

(49 citation statements)

References 370 publications

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“…The chemical structure of vegetable cellulose and bacterial cellulose are the same. However, bacterial cellulose has advantages such as high purity (as it is free of lignin and hemicellulose), high crystallinity (84–89%), high water retention (100 times its dry weight), good mechanical properties and 3D nanofibrous structure [ 84 , 85 , 86 , 87 , 88 ] These characteristics make BC a potential material for different applications [ 89 ].…”

Section: Bacteria Cellulose: An Innovative Biomaterialsmentioning

confidence: 99%

“…Such bacteria produce cellulose at the interface of air and culture medium, similar to a film for a flotation mechanism, which allows the bacteria to stay in the air/liquid near the interface to get the oxygen needed for their metabolism. The film obtained forms a physical barrier protection against UV radiation, increases the ability to colonize other substrates and maintains its hygroscopic nature, enables moisture retention and prevents dehydration [ 83 , 89 ]. Bacterial cellulose produced under static conditions normally has high crystallinity and tensile strength [ 89 ].…”

Section: Bacteria Cellulose: An Innovative Biomaterialsmentioning

confidence: 99%

“…The film obtained forms a physical barrier protection against UV radiation, increases the ability to colonize other substrates and maintains its hygroscopic nature, enables moisture retention and prevents dehydration [ 83 , 89 ]. Bacterial cellulose produced under static conditions normally has high crystallinity and tensile strength [ 89 ]. Under agitation conditions, the bacteria form a fluffy, spherical or irregular cellulose in the medium; Unlike the static method, cultivation under agitation fills the culture medium with oxygen and enables faster cell growth.…”

Section: Bacteria Cellulose: An Innovative Biomaterialsmentioning

confidence: 99%

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Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine

Silva

Pantoja

Almeida

et al. 2022

IJMS

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Cardiovascular diseases are considered the leading cause of death in the world, accounting for approximately 85% of sudden death cases. In dogs and cats, sudden cardiac death occurs commonly, despite the scarcity of available pathophysiological and prevalence data. Conventional treatments are not able to treat injured myocardium. Despite advances in cardiac therapy in recent decades, transplantation remains the gold standard treatment for most heart diseases in humans. In veterinary medicine, therapy seeks to control clinical signs, delay the evolution of the disease and provide a better quality of life, although transplantation is the ideal treatment. Both human and veterinary medicine face major challenges regarding the transplantation process, although each area presents different realities. In this context, it is necessary to search for alternative methods that overcome the recovery deficiency of injured myocardial tissue. Application of biomaterials is one of the most innovative treatments for heart regeneration, involving the use of hydrogels from decellularized extracellular matrix, and their association with nanomaterials, such as alginate, chitosan, hyaluronic acid and gelatin. A promising material is bacterial cellulose hydrogel, due to its nanostructure and morphology being similar to collagen. Cellulose provides support and immobilization of cells, which can result in better cell adhesion, growth and proliferation, making it a safe and innovative material for cardiovascular repair.

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Section: Bacteria Cellulose: An Innovative Biomaterialsmentioning

confidence: 99%

Section: Bacteria Cellulose: An Innovative Biomaterialsmentioning

confidence: 99%

Section: Bacteria Cellulose: An Innovative Biomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine

Silva

Pantoja

Almeida

et al. 2022

IJMS

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“…In this review, we will further present the main aspects concerning bacterial cellulose biosynthesis and its properties and applications with emphasis on its biomedical uses, such as in dressing materials and artificial scaffolds [ 36 ]. We will discuss various combinations of BC and different biopolymers (natural and synthetic) with several bioactive agents (metals, inorganic substances, plants extract, or drugs) to develop new materials and composites with a large applicability in the biomedical and biotechnological domains [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Cellulose—A Remarkable Polymer as a Source for Biomaterials Tailoring

et al. 2022

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Nowadays, the development of new eco-friendly and biocompatible materials using ‘green’ technologies represents a significant challenge for the biomedical and pharmaceutical fields to reduce the destructive actions of scientific research on the human body and the environment. Thus, bacterial cellulose (BC) has a central place among these novel tailored biomaterials. BC is a non-pathogenic bacteria-produced polysaccharide with a 3D nanofibrous structure, chemically identical to plant cellulose, but exhibiting greater purity and crystallinity. Bacterial cellulose possesses excellent physicochemical and mechanical properties, adequate capacity to absorb a large quantity of water, non-toxicity, chemical inertness, biocompatibility, biodegradability, proper capacity to form films and to stabilize emulsions, high porosity, and a large surface area. Due to its suitable characteristics, this ecological material can combine with multiple polymers and diverse bioactive agents to develop new materials and composites. Bacterial cellulose alone, and with its mixtures, exhibits numerous applications, including in the food and electronic industries and in the biotechnological and biomedical areas (such as in wound dressing, tissue engineering, dental implants, drug delivery systems, and cell culture). This review presents an overview of the main properties and uses of bacterial cellulose and the latest promising future applications, such as in biological diagnosis, biosensors, personalized regenerative medicine, and nerve and ocular tissue engineering.

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“…The concept of modern or advanced wound dressings includes the use of materials that have specific properties-such as controlling the moisture of the lesion microenvironmentbeing able to remove excess exudate generated in the healing process, which allows thermal insulation and gas exchange, antimicrobial action, and adaptation to the injured surface [14,15]. Natural polymers, also called biopolymers, have been widely used in the regenerative therapeutic sector for the elaboration of wound dressings, since they comprise a group of high-performance materials of low environmental impact and wide availability.…”

Section: Introductionmentioning

confidence: 99%

Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment

et al. 2022

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The use of innate products for the fast and efficient promotion of healing process has been one of the biomedical sector’s main bets for lesion treatment modernization process. The aim of this study was to develop and characterize bacterial cellulose-based (BC) wound dressings incorporated with green and red propolis extract (2 to 4%) and the active compounds p-coumaric acid and biochanin A (8 to 16 mg). The characterization of the nine developed samples (one control and eight active wound dressings) evidenced that the mechanics, physics, morphological, and barrier properties depended not only on the type of active principle incorporated onto the cellulosic matrix, but also on its concentration. Of note were the results found for transparency (28.59–110.62T600 mm−1), thickness (0.023–0.046 mm), swelling index (48.93–405.55%), water vapor permeability rate (7.86–38.11 g m2 day−1), elongation (99.13–262.39%), and antioxidant capacity (21.23–86.76 μg mL−1). The wound dressing based on BC and red propolis was the only one that presented antimicrobial activity. The permeation and retention test revealed that the wound dressing containing propolis extract presented the most corneal stratum when compared with viable skin. Overall, the developed wound dressing showed potential to be used for treatment against different types of dermal lesions, according to its determined proprieties.

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Bacterial cellulose and its potential for biomedical applications

Cited by 96 publications

References 370 publications

Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine

Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine

Bacterial Cellulose—A Remarkable Polymer as a Source for Biomaterials Tailoring

Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment

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