Bacterial cellulose membrane produced by Acetobacter sp. A10 for burn wound dressing applications

Bacterial cellulose as a material for wound treatment: Properties and modifications. A review

“…Subcutaneous implantation of these BC nanofibers in BALB/c mice did not change the normal development of the animals; no differences were noted in histological analyses of the internal organs between implanted and control animals (Pertile et al, 2011). No toxicity in the liver and kidney organs of SD rats was observed when the rat model was used to study the efficiency of BC wound dressings (Kwak et al, 2015). The absence of cytotoxic effects of BC nanofibers on either cell apoptosis or the cell cycle has been confirmed in in vivo studies by Jeong et al (2010) using C57/Bl6 mice and in in vitro studies on human umbilical vein endothelial cells (HUVECs).…”

“…The efficiency of BC based wound dressing as a material supporting tissue regeneration has been investigated in extensive medical studies (Kwak et al, 2015, Muangman et al, 2011. Rapid and efficient healing of severe chronic and burn wounds has been repeatedly reported by different research groups.…”

In vitro and in vivo investigation of bacterial cellulose dressing containing uniform silver sulfadiazine nanoparticles for burn wound healing

“…BC displays high purity, tensile strength, water holding capacity, and biocompatibility, and has a unique nanofibril network morphology which mimics the extracellular matrix [7,8]. Due to these special properties, BC has gained particular interest recently in biomedical applications, such as drug-delivery application [9], vascular [10] and blood vessels [11,12] graft, scaffolds for bone [13] and cartilage [14] tissue engineering, wound dressing [15,16] and skin repair [17]. Among them, wound dressing is one of BC's best known biomedical applications since BC can control wound exudates and provide moisture environment, which has been shown to accelerate wound healing [7,18].…”

Bacterial nanocelullose in biomedical applications: a review

“…Experiments made on mice in vivo , in which they were subjected to a study of skin healing on their back, showed that BNC dressings accelerated the wound healing process in comparison to ordinary dressings (gauze) . The confirmation that the BNC dressings accelerate wound healing is the higher number of newly created blood vessels, a higher level of collagen expression and a lower number of mast cells infiltrating the damaged site . A study on guinea pigs showed that BNC membranes accelerated the treatment of thick wounds.…”