Bacterial colonization and TH17 immunity are shaped by intestinal sialylation in neonatal mice

Irons, Eric E; Gomez, Eduardo Cortes; Andersen, Valerie L; Lau, Joseph T.Y.

doi:10.1093/glycob/cwac005

Cited by 8 publications

(3 citation statements)

References 146 publications

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“…Hepatic expression of ST6GAL1 is under the control of glucocorticoids [33] and cytokines that remain incompletely defined [33,34]. Many other cells and tissues also release ST6GAL1 into their environment, including lactating mammary glands [35], neonatal intestinal epithelium [36,37] and mature B cells [38]. Cancer cells, most notably lung, colon and breast express and release copious quantities of ST6GAL1 [39][40][41][42][43].…”

Section: Modes Of Sialylationmentioning

confidence: 99%

Sialic acid in the regulation of blood cell production, differentiation and turnover

Irons,

Gc,

Lau

2024

Immunology

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Sialic acid is a unique sugar moiety that resides in the distal and most accessible position of the glycans on mammalian cell surface and extracellular glycoproteins and glycolipids. The potential for sialic acid to obscure underlying structures has long been postulated, but the means by which such structural changes directly affect biological processes continues to be elucidated. Here, we appraise the growing body of literature detailing the importance of sialic acid for the generation, differentiation, function and death of haematopoietic cells. We conclude that sialylation is a critical post‐translational modification utilized in haematopoiesis to meet the dynamic needs of the organism by enforcing rapid changes in availability of lineage‐specific cell types. Though long thought to be generated only cell‐autonomously within the intracellular ER‐Golgi secretory apparatus, emerging data also demonstrate previously unexpected diversity in the mechanisms of sialylation. Emphasis is afforded to the mechanism of extrinsic sialylation, whereby extracellular enzymes remodel cell surface and extracellular glycans, supported by charged sugar donor molecules from activated platelets.

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Section: Modes Of Sialylationmentioning

confidence: 99%

Sialic acid in the regulation of blood cell production, differentiation and turnover

Irons,

Gc,

Lau

2024

Immunology

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“…The gut microbiota can also mediate Th17 responses. A study found that microbiome-dependent Th17 inflammation is regulated by α2,6-sialyl ligands, where α2,6-sialyltransferase deficiency induced mucosal Th17 responses [72]. Pathological Th17 cells can also be promoted by the Actinobacterium Eggerthella lenta through help by the cardiac glycoside reductase 2 enzyme [73] and Fusobacterium nucleatum via the short-chain fatty acid, butyrate [74].…”

Section: Interaction Between Gut Microbiota and Adaptive Immune Systemmentioning

confidence: 99%

Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

et al. 2023

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Gut microbes and their metabolites are actively involved in the development and regulation of host immunity, which can influence disease susceptibility. Herein, we review the most recent research advancements in the gut microbiota–immune axis. We discuss in detail how the gut microbiota is a tipping point for neonatal immune development as indicated by newly uncovered phenomenon, such as maternal imprinting, in utero intestinal metabolome, and weaning reaction. We describe how the gut microbiota shapes both innate and adaptive immunity with emphasis on the metabolites short-chain fatty acids and secondary bile acids. We also comprehensively delineate how disruption in the microbiota–immune axis results in immune-mediated diseases, such as gastrointestinal infections, inflammatory bowel diseases, cardiometabolic disorders (e.g., cardiovascular diseases, diabetes, and hypertension), autoimmunity (e.g., rheumatoid arthritis), hypersensitivity (e.g., asthma and allergies), psychological disorders (e.g., anxiety), and cancer (e.g., colorectal and hepatic). We further encompass the role of fecal microbiota transplantation, probiotics, prebiotics, and dietary polyphenols in reshaping the gut microbiota and their therapeutic potential. Continuing, we examine how the gut microbiota modulates immune therapies, including immune checkpoint inhibitors, JAK inhibitors, and anti-TNF therapies. We lastly mention the current challenges in metagenomics, germ-free models, and microbiota recapitulation to a achieve fundamental understanding for how gut microbiota regulates immunity. Altogether, this review proposes improving immunotherapy efficacy from the perspective of microbiome-targeted interventions.

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“…Additionally, Th17 responses can also be influenced by the gut microbiota [ 38 ]. The microbiome-dependent Th17 inflammation is regulated by α2,6-sialyl ligands; α2,6-sialyltransferase deficiency can induce mucosal Th17 responses [ 39 ]. Actinobacterium Eggerthella lenta can also promote pathological Th17 cells through the cardiac glycoside reductase 2 enzyme.…”

Section: The Molecular Role Of the Gut Microbiota In Asthma Pathogenesismentioning

confidence: 99%

The Role of the Microbiome in the Pathogenesis and Treatment of Asthma

Logoń,

Świrkosz,

Nowak

et al. 2023

Biomedicines

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The role of the microbiome in the pathogenesis and treatment of asthma is significant. The purpose of this article is to show the interplay between asthma and the microbiome, and main areas that require further research are also highlighted. The literature search was conducted using the PubMed database. After a screening process of studies published before May 2023, a total of 128 articles were selected in our paper. The pre-treatment bronchial microbiome in asthmatic patients plays a role in their responsiveness to treatment. Gut microbiota and its dysbiosis can contribute to immune system modulation and the development of asthma. The association between the microbiome and asthma is complex. Further research is necessary to clarify which factors might moderate that relationship. An appropriate gut microbiome and its intestinal metabolites are a protective factor for asthma development. Prebiotics and certain dietary strategies may have a prophylactic or therapeutic effect, but more research is needed to establish final conclusions. Although the evidence regarding probiotics is ambiguous, and most meta-analyses do not support the use of probiotic intake to reduce asthma, several of the most recent studies have provided promising effects. Further studies should focus on the investigation of specific strains and the examination of their mechanistic and genetic aspects.

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Bacterial colonization and TH17 immunity are shaped by intestinal sialylation in neonatal mice

Cited by 8 publications

References 146 publications

Sialic acid in the regulation of blood cell production, differentiation and turnover

Sialic acid in the regulation of blood cell production, differentiation and turnover

Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy

The Role of the Microbiome in the Pathogenesis and Treatment of Asthma

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