Bacterial community collapse: a meta‐analysis of the sinonasal microbiota in chronic rhinosinusitis

Mackenzie, Brett Wagner; Waite, David W.; Hoggard, Michael; Douglas, Richard; Taylor, Michael W.; Biswas, Kristi

doi:10.1111/1462-2920.13632

Cited by 163 publications

(199 citation statements)

References 77 publications

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“…The role of Corynebacterium within the gut microbiota is not well studied. However, increased abundances of Corynebacterium have been associated with chronic inflammation of the nasal sinus (Abreu et al., ; Wagner Mackenzie et al., ), induced inflammation of the gut (Ribière et al., ) and viral infection in pandas (Zhao et al., ), collectively indicating these bacteria may be associated with inflammatory immune responses. Moreover, Rooks et al.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota of a long‐distance migrant demonstrates resistance against environmental microbe incursions

et al. 2017

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Migratory animals encounter suites of novel microbes as they move between disparate sites during their migrations, and are frequently implicated in the global spread of pathogens. Although wild animals have been shown to source a proportion of their gut microbiota from their environment, the susceptibility of migrants to enteric infections may be dependent upon the capacity of their gut microbiota to resist incorporating encountered microbes. To evaluate migrants' susceptibility to microbial invasion, we determined the extent of microbial sourcing from the foraging environment and examined how this influenced gut microbiota dynamics over time and space in a migratory shorebird, the Red-necked stint Calidris ruficollis. Contrary to previous studies on wild, nonmigratory hosts, we found that stint on their nonbreeding grounds obtained very little of their microbiota from their environment, with most individuals sourcing only 0.1% of gut microbes from foraging sediment. This microbial resistance was reflected at the population level by only weak compositional differences between stint flocks occupying ecologically distinct sites, and by our finding that stint that had recently migrated 10,000 km did not differ in diversity or taxonomy from those that had inhabited the same site for a full year. However, recent migrants had much greater abundances of the genus Corynebacterium, suggesting a potential microbial response to either migration or exposure to a novel environment. We conclude that the gut microbiota of stint is largely resistant to invasion from ingested microbes and that this may have implications for their susceptibility to enteric infections during migration.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota of a long‐distance migrant demonstrates resistance against environmental microbe incursions

et al. 2017

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“…One such example is chronic rhinosinusitis (CRS), characterized by prolonged inflammation of the sinuses and a shift from a Th1 to a Th2 response (Aurora et al, 2013). Microbial communities in the paranasal sinuses of CRS patients are less rich and less diverse than commensal communities in healthy individuals (Wagner Mackenzie et al, 2017). Linear discriminant analysis identified the genus Corynebacterium as a potential biomarker that was over-represented in CRS.…”

Section: Pathogens As Disturbance: Mechanisms Of Interplay Between Homentioning

confidence: 99%

The Landscape Ecology and Microbiota of the Human Nose, Mouth, and Throat

Proctor

Relman

2017

Cell Host & Microbe

163

152

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Landscape ecology examines the relationships between the spatial arrangement of different landforms and the processes that give rise to spatial and temporal patterns in local community structure. These relationships that underlie the patterns of the microbial communities that inhabit the human body, and in particular, those of the nose, mouth and throat, deserve greater attention. Important questions include what defines the size of a population (i.e., ‘patch’) in a given body site; what defines the boundaries of distinct patches within a single body site, and where and over what spatial scales within a body site are gradients detected. This review looks at the landscape ecology in the upper respiratory tract and mouth, and seeks greater clarity about the physiological factors, whether immunological, chemical or physical, that govern microbial community composition and function, and the ecological traits that underlie health and disease.

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“…Increased relative abundance and diversity-particularly of Propionibacterium, Burkholderia, and L. sakei-was associated with healthy sinuses. The first two bacteria are also called "gatekeepers" and are thought to play an important role in maintaining a stable sinonasal community [28]. It is important to note that the studies that examined the microbiome in healthy subjects demonstrated the presence of Staphylococcus, Streptococcus, and Pseudomonas, bacteria known to cause respiratory disease [6,7,16].…”

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confidence: 99%

State-of-the-Art Adult Chronic Rhinosinusitis Microbiome: Perspective for Future Studies in Pediatrics

Pasha

2018

Sinusitis

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Chronic rhinosinusitis (CRS) is a prevalent disease that causes persistent mucosal inflammation and is associated with bacterial infection, which is thought to play a role in the inflammatory process. Microbiome analysis provides insight to host-microbial interactions. Disturbances in the host and commensal bacteria interaction may lead to CRS. Culture-based methods are useful to isolate some microorganisms but are unable to grow a majority of the bacteria. A review of the literature shows that several recent studies attempted to overcome this issue by using molecular techniques, such as microbial RNA sequencing, to describe the CRS microbiome. All of these studies were performed in adults, with no comparative studies reported in the pediatric population. Similar studies, utilizing molecular techniques, are needed to better understand the mechanism of CRS in children. Because valuable data from these adult studies may help to bridge the gap in our knowledge of the microbiome in pediatric CRS, we present an overview of the methodology and results behind the current microbiomic approach to adult CRS to set the stage for its use in the study of CRS in children.Keywords: microbiome; pediatric chronic rhinosinusitis; molecular techniquesThe field of the microbiological study of chronic rhinosinusitis (CRS) in adults has taken a quantum leap forward in only a few years. Unfortunately, similar approaches to the study of CRS in children have been totally lacking in the literature. A Medline search was performed for articles reporting on the microbiome in patients with CRS. Search terms included: 16S ribosomal RNA (rRNA) gene sequencing in chronic rhinosinusitis, chronic rhinosinusitis and microbiome, chronic rhinosinusitis and pyrosequencing, non-cultured molecular techniques in chronic rhinosinusitis, microbiome and 16S ribosome RNA. The following is an overview of the reported methodology and results behind the current microbiomic approach to adult CRS with the goal to set the stage for its use in the future studies of pediatric CRS.Bacterial rhinosinusitis is one of the most common problems presented to the primary care physician's office and results in over $5 billion in direct costs annually [1]. CRS symptoms lasting >12 weeks with or without exacerbations, affects more than 30 million Americans, which results in over $2.4 billion in annual health care expenditures [2]. CRS is considered an inflammatory disorder of the paranasal sinuses. Analysis of direct microbial cultures, sinus secretions, and tissue samples has demonstrated the presence of bacteria. It has been speculated that the bacterial colonization in CRS plays a role in pathophysiology of the disease [3,4]. Despite these findings, the role of microbial stimuli causing inflammation in CRS remains controversial [5].

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Bacterial community collapse: a meta‐analysis of the sinonasal microbiota in chronic rhinosinusitis

Cited by 163 publications

References 77 publications

Gut microbiota of a long‐distance migrant demonstrates resistance against environmental microbe incursions

Gut microbiota of a long‐distance migrant demonstrates resistance against environmental microbe incursions

The Landscape Ecology and Microbiota of the Human Nose, Mouth, and Throat

State-of-the-Art Adult Chronic Rhinosinusitis Microbiome: Perspective for Future Studies in Pediatrics

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