Bacterial Endocarditis Associated with Colored Carcinoma

Roses, Daniel F.; Richman, Howard; Localio, S. Arthur

doi:10.1097/00000658-197402000-00015

Cited by 42 publications

(24 citation statements)

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“…This was followed in 1974 by a report of three more cases of bacterial endocarditis associated with colorectal carcinoma. 3 Also in 1974, Hoppes and Lerner 4 discussed subdividing the causes of streptococcal endocarditis into two categories: enterococcal group, and viridans group. 4 They further defined a category of nonenterococcal species, which included S. bovis.…”

Section: Discussionmentioning

confidence: 99%

Unusual Bacterial Infections and Colorectal Carcinoma— Streptococcus bovis and Clostridium septicum : Report of Three Cases

Wentling

Metzger

Dozois

et al. 2006

Diseases of the Colon &Amp; Rectum

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Section: Discussionmentioning

confidence: 99%

Unusual Bacterial Infections and Colorectal Carcinoma— Streptococcus bovis and Clostridium septicum : Report of Three Cases

Wentling

Metzger

Dozois

et al. 2006

Diseases of the Colon &Amp; Rectum

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“…These organisms are the most frequently encountered clinical isolates among group D streptococci and the second-most important streptococcal cause of endocarditis after "oral streptococci" (4,15,55) which, however, are now classified into many different species and even different genera (16,28). S. bovis group isolates are considered to be commensals in the intestinal tract, but they have been found only in ϳ2.5% to 15% of the human population (9,24,38,58).…”

mentioning

confidence: 99%

A Collagen-Binding Adhesin, Acb, and Ten Other Putative MSCRAMM and Pilus Family Proteins of Streptococcus gallolyticus subsp. gallolyticus ( Streptococcus bovis Group, Biotype I)

Sillanpää¹,

Nallapareddy²,

Qin

et al. 2009

J Bacteriol

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Members of the Streptococcus bovis group are important causes of endocarditis. However, factors associated with their pathogenicity, such as adhesins, remain uncharacterized. We recently demonstrated that endocarditis-derived Streptococcus gallolyticus subsp. gallolyticus isolates frequently adhere to extracellular matrix (ECM) proteins. Here, we generated a draft genome sequence of an ECM protein-adherent S. gallolyticus subsp. gallolyticus strain and found, by genome-wide analyses, 11 predicted LPXTG-type cell wall-anchored proteins with characteristics of MSCRAMMs, including a modular architecture of domains predicted to adopt immunoglobulin (Ig)-like folding. A recombinant segment of one of these, Acb, showed high-affinity binding to immobilized collagen, and cell surface expression of Acb correlated with the presence of acb and collagen adherence of isolates. Three of the 11 proteins have similarities to major pilus subunits and are organized in separate clusters, each including a second Ig-fold-containing MSCRAMM and a class C sortase, suggesting that the sequenced strain encodes three distinct types of pili. Reverse transcription-PCR demonstrated that all three genes of one cluster, acb-sbs7-srtC1, are cotranscribed, consistent with pilus operons of other grampositive bacteria. Further analysis detected expression of all 11 genes in cells grown to mid to late exponential growth phases. Wide distribution of 9 of the 11 genes was observed among S. gallolyticus subsp. gallolyticus isolates with fewer genes present in other S. bovis group species/subspecies. The high prevalence of genes encoding putative MSCRAMMs and pili, including a collagen-binding MSCRAMM, among S. gallolyticus subsp. gallolyticus isolates may play an important role in the predominance of this subspecies in S. bovis endocarditis.Members of the Streptococcus bovis group have long been regarded as opportunistic pathogens and are important causes of endocarditis in humans. These organisms are the most frequently encountered clinical isolates among group D streptococci and the second-most important streptococcal cause of endocarditis after "oral streptococci" (4, 15, 55) which, however, are now classified into many different species and even different genera (16, 28). S. bovis group isolates are considered to be commensals in the intestinal tract, but they have been found only in ϳ2.5% to 15% of the human population (9,24,38,58). Surprisingly, there is a clear correlation-for unknown reasons-between the isolation of S. bovis group organisms as the causative agent of endocarditis and the presence of cancerous lesions and polyps in the intestinal tracts of patients (3,20,24,57), with the first suggestion of this association dating back to 1951 (36). Among patients with carcinoma of the colon, an increased S. bovis carriage rate of 56% was found (24). Whether this increased occurrence is a cause or effect of colon cancer is unclear. However, the association of S. bovis bacteremia or endocarditis with colon cancer raises the intriguing hypothesis...

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“…It is a non-enterococcal streptococcus in Lancefield's group D that can cause bacteremia and endocarditis, as well as urinary infection (2) . Infectious endocarditis from S. bovis is the second greatest cause of endocarditis from streptococci (1,8,24) The normal human colon is a significant reservoir for S. bovis in 2.5% to 15% of individuals (5,21) . S. bovis colonizes the thrombin of platelets and fibrin, where its colonies become developed with protection from new layers of platelets and fibrin that are formed by stimulation from thromboplastin (22) .…”

Section: Discussionmentioning

confidence: 99%

“…Colonic neoplasia may arise years after the presentation of the condition of bacteremia or infectious endocarditis (9,10,27) . In addition to the bacteremia and infectious endocarditis from S. bovis, endocarditis caused by other streptococci like S. faecalis (18) and S. equines (11,17) and the bacteremia introduced by S. sanguis, S. equinus and S. salivaris have also been related to colonic neoplasias (24) . The diagnosis of infectious endocarditis is normally done in the laboratory via hemoculture, as was done in the present case, for which the positivity rate is 95%.…”

Section: Discussionmentioning

confidence: 99%

“…suggested a relationship between colonic carcinoma and the presence of infectious endocarditis in 1951, it was only in 1974 that the association of Streptococcus bovis (S. bovis) and colorectal neoplasia was recognized (16,24) . S. bovis accounts for approximately 14% of the cases of infectious endocarditis and 13% of all cases of infectious endocarditis are caused by bacteria that have gastrointestinal origin (4) .…”

Section: Although Mccoy and Masonmentioning

confidence: 99%

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Infectious endocarditis from Streptococcus bovis associated with colonic carcinoma: case report and literature review

Waisberg

Matheus

Pimenta

2002

Arq. Gastroenterol.

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-Background -Many studies in the literature have warned of the need for investigation of colonic lesions among patients, especially elderly ones, who have bacteremia and/or endocarditis from Streptococcus bovis. Bacteremia and infectious endocarditis from Streptococcus bovis may be related to the presence of neoplastic lesions in the large intestine and hepatic disease. Aim -This report describes a patient who presented infectious endocarditis from Streptococcus bovis associated with colonic carcinoma and tubular-villous adenomas. Conclusions -The finding of this bacterium among patients with septicemia and/or endocarditis is also related to the presence of villous or tubular-villous adenomas in the large intestine. For this reason, complete and detailed investigation of the large intestine must be performed in patients with infectious endocarditis, even in the absence of intestinal symptoms. An increased incidence of this condition or hepatic dysfunction has been reported among patients with infectious endocarditis from Streptococcus bovis. Patients with infectious endocarditis from Streptococcus bovis and normal colonoscopy may be included in the group at risk for developing colonic cancer. The knowledge that there is an association between endocarditis from Streptococcus bovis and carcinoma of the colon has important clinical implications. If the lesion can be discovered at an early stage, curative resection may become possible.

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Bacterial Endocarditis Associated with Colored Carcinoma

Cited by 42 publications

References 5 publications

Unusual Bacterial Infections and Colorectal Carcinoma— Streptococcus bovis and Clostridium septicum : Report of Three Cases

Unusual Bacterial Infections and Colorectal Carcinoma— Streptococcus bovis and Clostridium septicum : Report of Three Cases

A Collagen-Binding Adhesin, Acb, and Ten Other Putative MSCRAMM and Pilus Family Proteins of Streptococcus gallolyticus subsp. gallolyticus ( Streptococcus bovis Group, Biotype I)

Infectious endocarditis from Streptococcus bovis associated with colonic carcinoma: case report and literature review

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