Bacterial-Induced Blood Pressure Reduction: Mechanisms for the Treatment of Hypertension via the Gut

Cookson, T A

doi:10.3389/fcvm.2021.721393

Cited by 24 publications

(18 citation statements)

References 130 publications

(103 reference statements)

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“…Although the underlying mechanisms by which Limosilactobacillus fermentum reduced blood pressure have not been assessed in the present study, some possible pathways related to probiotic-induced-hypotensive effects have been proposed. 33 First, it has been demonstrated that gut barrier integrity can be rescued by probiotic therapy, reducing LPS-translocation, inflammation, sympathetic activity, endothelial dysfunction, and blood pressure. 29,34 Second, short-chain fatty acids (SCFA), including acetate, propionate, and butyrate, are produced by specific gut microbes and can be enhanced during probiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

Limosilactobacillus fermentum prevents gut-kidney oxidative damage and the rise in blood pressure in male rat offspring exposed to a maternal high-fat diet

Nascimento

Souza

Freire

et al. 2022

J Dev Orig Health Dis

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Oxidative stress along the gut-kidney axis is a risk factor for developing arterial hypertension in offspring from dams fed a high-fat diet. Considering the antioxidant capacity of probiotic strains, this study evaluated the effects of a daily multistrain formulation with Limosilactobacillus fermentum 139, 263, and 296 on blood pressure (BP), renal function, and oxidative stress and along the gut-kidney axis in male offspring from dams fed a high-fat high-cholesterol (HFHC) diet during pregnancy and lactation. Dams were fed a diet control or HFHC diet during pregnancy and lactation. At 100 days of age, part of the male offspring from dams fed a HFHC diet received Limosilactobacillus fermentum formulation for 4 weeks (HFHC + Lf) daily. After the 4-week intervention, BP (tail-cuff plethysmography) and urinary and biochemical variables were measured. In addition, malondialdehyde levels, enzymatic activities of superoxide dismutase, catalase, glutathione-S-transferase, and nonenzymatic antioxidant defense (thiols content) were measured in the colon and renal cortex. Male offspring from dams fed a HFHC had increased blood pressure, impaired renal function, and oxidative stress along the gut-kidney axis. Administration of Limosilactobacillus fermentum reduced systolic, diastolic, and mean blood pressure levels and alleviated renal function impairment and oxidative stress along the gut-kidney axis in male offspring from dams fed a HFHC diet. Administration of Limosilactobacillus fermentum formulation attenuated programmed hypertension in the HFHC group through oxidative stress modulation along the gut-kidney axis.

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Section: Discussionmentioning

confidence: 99%

Limosilactobacillus fermentum prevents gut-kidney oxidative damage and the rise in blood pressure in male rat offspring exposed to a maternal high-fat diet

Nascimento

Souza

Freire

et al. 2022

J Dev Orig Health Dis

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“…Gut microbiome has various effects for host homeostasis contributing to blood pressure regulation [43]. For example, changes in gut microbiome in SHR reduced blood pressure through the reduction of SNA [44].…”

Section: Discussionmentioning

confidence: 99%

Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension

Yamamoto

Otani

Okada

et al. 2021

IJMS

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Adipocytokine chemerin is a biologically active molecule secreted from adipose tissue. Chemerin elicits a variety of functions via chemokine-like receptor 1 (CMKLR1). The cardiovascular center in brain that regulates blood pressure (BP) is involved in pathophysiology of systemic hypertension. Thus, we explored the roles of brain chemerin/CMKLR1 on regulation of BP in spontaneously hypertensive rats (SHR). For this aim, we examined effects of intracerebroventricular (i.c.v.) injection of CMKLR1 small interfering (si)RNA on both systemic BP as measured by tail cuff system and protein expression in paraventricular nucleus (PVN) of SHR as determined by Western blotting. We also examined both central and peripheral protein expression of chemerin by Western blotting. Systolic BP of SHR but not normotensive Wistar Kyoto rats (WKY) was decreased by CMKLR1 siRNA. The decrease of BP by CMKLR1 siRNA persisted for 3 days. Protein expression of CMKLR1 in PVN of SHR tended to be increased compared with WKY, which was suppressed by CMKLR1 siRNA. Protein expression of chemerin in brain, peripheral plasma, and adipose tissue was not different between WKY and SHR. In summary, we for the first time revealed that the increased protein expression of CMKLR1 in PVN is at least partly responsible for systemic hypertension in SHR.

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“…Indoles are aromatic, heterocyclic, organic compounds that can be produced through gut microbiota. Gut microbes can express indole‐3‐glycerol phosphate synthase, indole‐3‐glucerol phosphate lyase, and indole synthase, which may promote the production of indole 106 . Indole has been reported to be associated with hypertension.…”

Section: The Potential Mechanisms Involved In the Regulation Between ...mentioning

confidence: 99%

“…Gut microbes can express indole-3-glycerol phosphate synthase, indole-3-glucerol phosphate lyase, and indole synthase, which may promote the production of indole. 106 Indole has been reported to be associated with hypertension. Administration of indole increased BP dose-dependently in rats.…”

Section: Immunity Responsementioning

confidence: 99%

Regulatory effect of gut microbes on blood pressure

Yan

Sun

Zhou

et al. 2022

Anim Models and Exp Med

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Hypertension is an important global public health issue because of its high morbidity as well as the increased risk of other diseases. Recent studies have indicated that the development of hypertension is related to the dysbiosis of the gut microbiota in both animals and humans. In this review, we outline the interaction between gut microbiota and hypertension, including gut microbial changes in hypertension, the effect of microbial dysbiosis on blood pressure (BP), indicators of gut microbial dysbiosis in hypertension, and the microbial genera that affect BP at the taxonomic level. For example, increases in Lactobacillus, Roseburia, Coprococcus, Akkermansia, and Bifidobacterium are associated with reduced BP, while increases in Streptococcus, Blautia, and Prevotella are associated with elevated BP. Furthermore, we describe the potential mechanisms involved in the regulation between gut microbiota and hypertension. Finally, we summarize the commonly used treatments of hypertension that are based on gut microbes, including fecal microbiota transfer, probiotics and prebiotics, antibiotics, and dietary supplements. This review aims to find novel potential genera for improving hypertension and give a direction for future studies on gut microbiota in hypertension.

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Bacterial-Induced Blood Pressure Reduction: Mechanisms for the Treatment of Hypertension via the Gut

Cited by 24 publications

References 130 publications

Limosilactobacillus fermentum prevents gut-kidney oxidative damage and the rise in blood pressure in male rat offspring exposed to a maternal high-fat diet

Limosilactobacillus fermentum prevents gut-kidney oxidative damage and the rise in blood pressure in male rat offspring exposed to a maternal high-fat diet

Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension

Regulatory effect of gut microbes on blood pressure

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