Bacterial iron metabolism: Investigations on the mechanism of ferrichrome function

Burnham, Bruce F.

doi:10.1016/0003-9861(62)90085-1

Cited by 27 publications

(11 citation statements)

References 17 publications

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“…He found that when this organism is grown on heme in the complete absence of ferrichrome, the cells are permeable to inorganic iron even though this organism does not respond to massive amounts of inorganic iron for growth (20). Although this finding does not rule out the possibility that a ferrichrome transport system may be operative, it does suggest that iron transport is not the sole function of ferrichrome in supporting growth of this organism.…”

Section: Hydroxamic Acids As Iron-transport Agentsmentioning

confidence: 42%

“…The monohydroxamates, fusarinine and hadacidin, show no growth factor activity; aspergillic Protohemin and coprohemin are the only nonhydroxamates that approach ferrichrome in activity toward Arthrobacter JG-9. Halfmaximal growth factor activity is found at about 100 ng/ml, although this activity can be increased further in the presence of protein (20).…”

Section: A Biological Activitymentioning

confidence: 99%

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Hydroxamic Acids of Natural Origin

Emery

1971

Advances in Enzymology - And Related Areas of Molecular Biology

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Section: Hydroxamic Acids As Iron-transport Agentsmentioning

confidence: 42%

Section: A Biological Activitymentioning

confidence: 99%

Hydroxamic Acids of Natural Origin

Emery

1971

Advances in Enzymology - And Related Areas of Molecular Biology

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“…It seems likely that such micro-organisms have lost not only the ability to synthesize sideramines, but have also lost much of their specificity for the siderochrome necessary to replace the natural sideramine. Under these circumstances, the loss of specificity would have survival value, Recent work on the metabolic function of ferrichrome provided evidence that this compound directly influences the ability of Arthrobacter JG-9 to incorporate iron into protoporphyrin (Burnham, 1962). I n the present paper additional evidence for the participation of ferrichrome in the synthesis of haemin is presented, and a possible site of action of the sideromycins is suggested.…”

Section: Introductionmentioning

confidence: 69%

Investigations on the Action of the Iron-Containing Growth Factors, Sideramines; and Iron-Containing Antibiotics, Sideromycins

Burnham

1963

Journal of General Microbiology

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SUMMARYThe formation of catalase activity by an Arthrobacter strain JG-9 is dependent upon the addition of exogenous haemin, or the iron-containing growth factor ferrichrome. The iron-containing antibiotic ferrimycin A inhibited the synthesis of catalase in bacterial suspensions supplemented with ferrichrome, but did not measurably alter catalase formation in suspensions supplemented with haemin. This suggests that ferrichrome is necessary for haemin (catalase) synthesis, and that ferrimycin A acts by blocking this step. Cell-free extracts of Rhodopseudornonas spheroides were able to synthesize haemin when incubated with an oxidizable substrate, protoporphyrin IX and iron supplied as ferrichrome.

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“…Arthrobacter JG 9 is inhibited by ferrimycin A. According to the investigations of BuRNHAM (1962a), this sideramine-heterotrophic strain is also able to take up free ferric-ions, but it cannot incorporate them into haemin. BuRNHAM (1962b) employed Arthrobacter JG 9 to study the antagonism between sideromycins and sideramines; catalase activity, rather than growth, was taken as a measure of antagonism of the sideramines.…”

Section: Biochemical Properties Of the Sideromycinsmentioning

confidence: 97%

Antibiotics

1967

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AII rights, especially that of tnmslation into foreign languages, reserved. It is also forbidden to reproduce this book, either whole DedicationFor most areas of scientific pursuit, there is usually that rare investigator who has the imagination to conceive ideas, who has faith in his visions, and who has the ability to critically test his concepts in the laboratory. Almost invariably, this scientist also inspires younger men to enthusiastically enter into his research program. To him should go the accolades and the recognitions of the esteem in which he is held. As only a small part of this esteem, we wish to dedicate these books to Professor SELMAN A. W AKSMAN in appreciation of his leadership and contributions in all facets of antibiotic research. PrefaceThe idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a bibliography on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving forward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master.That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and biosynthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known. Yet, such an approach would not entirely serve the purpose we projected, for it would not encompass all of the information available in these fields of antibiotic investigations and blind searches for the original literature would still have to be made. We therefore chose to include any and all antibiotics about which some pertinent information had been published. It was obvious even at the start that such a compilation, integration, and analysis of information could never be complete unless scientific investigations ceased at the moment the last manuscript was submitted-an end that was neither desirable nor possible. An addendum was therefore included at the end of the volume and left open for the addition of new information until the last pages of the regular articles had been printed.The original concept has also been further expanded as the authors of several papers found it advisable to elaborate on their subject. Some of the articles included discussions...

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Bacterial iron metabolism: Investigations on the mechanism of ferrichrome function

Cited by 27 publications

References 17 publications

Hydroxamic Acids of Natural Origin

Hydroxamic Acids of Natural Origin

Investigations on the Action of the Iron-Containing Growth Factors, Sideramines; and Iron-Containing Antibiotics, Sideromycins

Antibiotics

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