Bacterial Lipopolysaccharide Augmented Malignant Transformation and Promoted the Stemness in Prostate Cancer Epithelial Cells

Tang, Sijie; Lian, Xueqi; Cheng, Hong-Jian; Guo, Jiaqian; Ni, Daguang; Huang, Can; Gu, Xiang Lin; Meng, Hong; Jiang, Jiajia; Li, Xiaohua

doi:10.2147/jir.s332943

Cited by 6 publications

(4 citation statements)

References 61 publications

(70 reference statements)

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“…Many studies have shown that lipopolysaccharide (LPS) is involved in the proliferation, invasion, and metastasis of prostate cancer cells [27][28][29]. Recently, it has been found that intracellular LPS can activate the Caspase-4/5/11 pathway, induce pyroptosis, and inhibit tumour growth.…”

Section: Pyroptosis In Prostate Cancermentioning

confidence: 99%

Pyroptosis in urinary malignancies: a literature review

et al. 2023

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Urinary neoplasms refer to malignant tumours occurring in any part of the urinary system, including the kidney, renal pelvis, ureter, bladder, prostate, etc. The worldwide incidence of urinary system tumours has been increasing yearly. Available methods include surgical treatment, radiotherapy, chemotherapy, endocrine therapy, molecular targeted therapy, and immune therapy. In recent years, emerging evidence has demonstrated that cell pyroptosis plays an important role in the occurrence and progression of malignant urinary tumours. Pyroptosis is a new type of cell death that involves inflammatory processes regulated by gasdermins (GSDMs) and is characterized by membrane perforation, cell swelling and cell rupture. Recent studies have shown that pyroptosis can inhibit and promote the development of tumours. This manuscript reviews the role of pyroptosis in the development and progression of prostate cancer, kidney cancer and bladder cancer and introduces the latest research results in these fields to discuss the therapeutic potential of the pyroptosis pathway in urinary malignancies.

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Section: Pyroptosis In Prostate Cancermentioning

confidence: 99%

Pyroptosis in urinary malignancies: a literature review

et al. 2023

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“…In addition to IL6/gp130, STAT3 activation can be fulfilled by other factors. The literature reveals that monoamine oxidative A (MAOA), HOX transcript antisense RNA (HOTAIR), interleukin 10 (IL-10) and bacterial lipopolysaccharide (LPS) enable an increase in PCSC population via driving STAT3 signaling [96][97][98].…”

Section: Janus Kinase-signal Transducer and Activator Of Transcriptio...mentioning

confidence: 99%

The Molecular Biology of Prostate Cancer Stem Cells: From the Past to the Future

Zhou

Jia

et al. 2023

IJMS

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Prostate cancer (PCa) continues to rank as the second leading cause of cancer-related mortality in western countries, despite the golden treatment using androgen deprivation therapy (ADT) or anti-androgen therapy. With decades of research, scientists have gradually realized that the existence of prostate cancer stem cells (PCSCs) successfully explains tumor recurrence, metastasis and therapeutic failure of PCa. Theoretically, eradication of this small population may improve the efficacy of current therapeutic approaches and prolong PCa survival. However, several characteristics of PCSCs make their diminishment extremely challenging: inherent resistance to anti-androgen and chemotherapy treatment, over-activation of the survival pathway, adaptation to tumor micro-environments, escape from immune attack and being easier to metastasize. For this end, a better understanding of PCSC biology at the molecular level will definitely inspire us to develop PCSC targeted approaches. In this review, we comprehensively summarize signaling pathways responsible for homeostatic regulation of PCSCs and discuss how to eliminate these fractional cells in clinical practice. Overall, this study deeply pinpoints PCSC biology at the molecular level and provides us some research perspectives.

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“…These conflicting reports appear consistent when organized by model type and route of administration. For example, pro-tumor effects of LPS are consistently reported in (immunedeficient) animal models, or isolated cancer cells in vitro (without an immune coculture) or by assumptions drawn on greater expression levels for TLR4 reported in cancer vs. healthy adjacent tissue (164)(165)(166)(167)(168)(169)(170)(171)(172)(173)(174)(175). However, anti-tumor effects of LPS/TLR4 agonists are consistently reported in fully immune competent animals, the majority showing greater survival time, curative remission in a significant % of test groups similar to Coley's toxin, reduction of adverse effects of chemotherapy and radiation, including resistance (130-133, 176-178), and effects augmented when combined with anti-tumor cytokines (e.g.…”

Section: Lps/trl4 Agonists and Cancer Modelsmentioning

confidence: 99%

Plants against cancer: the immune-boosting herbal microbiome: not of the plant, but in the plant. Basic concepts, introduction, and future resource for vaccine adjuvant discovery

Mazzio,

Barnes,

Badisa

et al. 2023

Front. Oncol.

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The presence of microorganism communities (MOCs) comprised of bacteria, fungi, archaea, algae, protozoa, viruses, and the like, are ubiquitous in all living tissue, including plant and animal. MOCs play a significant role in establishing innate and acquired immunity, thereby influencing susceptibility and resistance to disease. This understanding has fostered substantial advancements in several fields such as agriculture, food science/safety, and the development of vaccines/adjuvants, which rely on administering inactivated-attenuated MOC pathogens. Historical evidence dating back to the 1800s, including reports by Drs Busch, Coley, and Fehleisen, suggested that acute febrile infection in response to “specific microbes” could trigger spontaneous tumor remission in humans. This discovery led to the purposeful administration of the same attenuated strains, known as “Coley’s toxin,” marking the onset of the first microbial (pathogen) associated molecular pattern (MAMPs or PAMPs)-based tumor immunotherapy, used clinically for over four decades. Today, these same MAMPS are consumed orally by billions of consumers around the globe, through “specific” mediums (immune boosting “herbal supplements”) as carriers of highly concentrated MOCs accrued in roots, barks, hulls, sea algae, and seeds. The American Herbal Products Association (AHPA) mandates microbial reduction in botanical product processing but does not necessitate the removal of dead MAMP laden microbial debris, which we ingest. Moreover, while existing research has focused on the immune-modulating role of plant phytochemicals, the actual immune-boosting properties might instead reside solely in the plant’s MOC MAMP laden biomass. This assertion is logical, considering that antigenic immune-provoking epitopes, not phytochemicals, are known to stimulate immune response. This review explores a neglected area of research regarding the immune-boosting effects of the herbal microbiome – a presence which is indirectly corroborated by various peripheral fields of study and poses a fundamental question: Given that food safety focuses on the elimination of harmful pathogens and crop science acknowledges the existence of plant microbiomes, what precisely are the immune effects of ingesting MAMPs of diverse structural composition and concentration, and where are these distributed in our botanicals? We will discuss the topic of concentrated edible MAMPs as acid and thermally stable motifs found in specific herbs and how these would activate cognate pattern recognition receptors (PPRs) in the upper gut-associated lymphoid tissue (GALT), including Peyer’s patches and the lamina propria, to boost antibody titers, CD8+ and CD4+ T cells, NK activity, hematopoiesis, and facilitating M2 to M1 macrophage phenotype transition in a similar manner as vaccines. This new knowledge could pave the way for developing bioreactor-grown/heat-inactivated MOC therapies to boost human immunity against infections and improve tumor surveillance.

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Bacterial Lipopolysaccharide Augmented Malignant Transformation and Promoted the Stemness in Prostate Cancer Epithelial Cells

Cited by 6 publications

References 61 publications

Pyroptosis in urinary malignancies: a literature review

Pyroptosis in urinary malignancies: a literature review

The Molecular Biology of Prostate Cancer Stem Cells: From the Past to the Future

Plants against cancer: the immune-boosting herbal microbiome: not of the plant, but in the plant. Basic concepts, introduction, and future resource for vaccine adjuvant discovery

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