Bacterial metastasis: the host plasminogen system in bacterial invasion

Lähteenmäki, Kaarina; Edelman, Sanna; Korhonen, Timo

doi:10.1016/j.tim.2004.12.003

Cited by 208 publications

(205 citation statements)

References 65 publications

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“…Upregulation of host plasminogen activator receptors has been observed during other bacterial infections, for example, with Staphylococcus aureus and Borrelia burgdorferi. 29 A strong and persistent upregulation of the cytochrome c oxidase VIIa polypeptide 2 (COX7A2) was found. COX is the terminal component of the mitochondrial respiratory chain, which catalyzes the electron transfer from reduced cytochrome c to oxygen.…”

Section: Transcriptional Host Response During Tularemia H Andersson Ementioning

confidence: 99%

Transcriptional profiling of the peripheral blood response during tularemia

et al. 2006

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Tularemia is a febrile disease caused by the highly contagious bacterium Francisella tularensis. We undertook an analysis of the transcriptional response in peripheral blood during the course of ulceroglandular tularemia by use of Affymetrix microarrays comprising 14 500 genes. Samples were obtained from seven individuals at five occasions during 2 weeks after the first hospital visit and convalescent samples 3 months later. In total, 265 genes were differentially expressed, 95 of which at more than one time point. The differential expression was verified with real-time quantitative polymerase chain reaction for 36 genes (R 2 ¼ 0.590). The most prominent changes were noted in samples drawn on days 2-3 and a considerable proportion of the upregulated genes appeared to represent an interferon-g-induced response and also a proapoptotic response. Genes involved in the generation of innate and acquired immune responses were found to be downregulated, presumably a pathogen-induced event. A logistic regression analysis revealed that seven genes were good predictors of the early phase of tularemia. This is the first description of the transcriptional host response to ulceroglandular tularemia and the study has identified gene subsets relevant to the pathogenesis of the disease and subsets that may serve as early diagnostic biomarkers.

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Section: Transcriptional Host Response During Tularemia H Andersson Ementioning

confidence: 99%

Transcriptional profiling of the peripheral blood response during tularemia

et al. 2006

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“…Plasminogen is converted to the serine protease plasmin by human activators, such as uPA or tissue-type plasminogen activator (56), and by bacterial activators like staphylokinase (57). In order for these activators to function, the appropriate domain of plasminogen needs to be accessible.…”

Section: Bba70-bound Plasminogen Can Be Activated To Plasmin-mentioning

confidence: 99%

BBA70 of Borrelia burgdorferi Is a Novel Plasminogen-binding Protein

Koenigs

Hammerschmidt

Jutras

et al. 2013

Journal of Biological Chemistry

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Background: Recruitment of plasminogen is important for efficient dissemination of Borrelia burgdorferi. Results: BBA70 of B. burgdorferi binds plasminogen, and following activation, bound plasmin can cleave fibrinogen and inactivate the key complement components C3b and C5. Conclusion: BBA70 is a potent plasminogen-binding protein.Significance: Investigation suggests that binding of plasminogen may aid in pathogen dissemination and inhibit bacteriolytic effects of the host complement system.

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“…Plasminogen is a 92-kDa protein circulating in the plasma at a concentration of ϳ180 g/ml (39). Recruitment of plasminogen to the bacterial surface is a virulence strategy used by many pathogenic bacteria (39), which can contribute to colonization (40,41) and bacterial dissemination (26,39,(42)(43)(44).…”

Section: Group B Streptococcus (Gbs)mentioning

confidence: 99%

“…Recruitment of plasminogen to the bacterial surface is a virulence strategy used by many pathogenic bacteria (39), which can contribute to colonization (40,41) and bacterial dissemination (26,39,(42)(43)(44). GBS-PGK has been previously demonstrated to bind plasminogen (38), raising the possibility that surface-expressed GBS-PGK (20,37,38) may be involved in recruiting plasminogen to the GBS surface.…”

Section: Group B Streptococcus (Gbs)mentioning

confidence: 99%