Bacterial-mucosal interactions in inflammatory bowel disease—an alliance gone bad

Chichlowski, Maciej; Hale, Laura P.

doi:10.1152/ajpgi.90516.2008

Cited by 96 publications

(75 citation statements)

References 121 publications

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“…Therefore, it is the first line of defense against luminal antigens and toxins. An impairment of this intestinal barrier is critical for pathogenesis of several diseases such as inflammatory bowel disease, celiac disease (Chichlowski et al, 2008) and atopic dermatitis (Rosenfeldt et al, 2004).…”

Section: The Effect Of Probiotics On the Intestinal Barrier Functionsmentioning

confidence: 99%

The Impact of Probiotics on the Gastrointestinal Physiology

Matur¹,

Evren²

2012

New Advances in the Basic and Clinical Gastroenterology

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Section: The Effect Of Probiotics On the Intestinal Barrier Functionsmentioning

confidence: 99%

The Impact of Probiotics on the Gastrointestinal Physiology

Matur¹,

Evren²

2012

New Advances in the Basic and Clinical Gastroenterology

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“…The penetration of microbes into the lamina propria results in a stronger inflammatory response, in part through activation of mucosal immune cells (24). Thus, strategies to reinforce the epithelial barrier and suppress mucosal immune activity could be beneficial in preventing stressor-induced exacerbations of GI diseases.…”

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confidence: 99%

Probiotic Lactobacillus reuteri Attenuates the Stressor-Enhanced Severity of Citrobacter rodentium Infection

et al. 2013

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dStressor exposure has been shown to enhance host susceptibility and the severity of a plethora of illnesses, including gastrointestinal disease. In mice, susceptibility to Citrobacter rodentium has been shown to be dependent on host genetics as well as the composition of the intestinal microbiota, but the effects of stressor exposure on this gastrointestinal pathogen have not been elucidated fully. Previously, our lab showed that exposure to the prolonged-restraint stressor prior to a challenge with C. rodentium alters the intestinal microbiota community structure, including a reduction of beneficial genera such as Lactobacillus, which may contribute to stressor-enhanced C. rodentium-induced infectious colitis. To test the effects of stressor exposure on C. rodentium infection, we exposed resistant mice to a prolonged-restraint stressor concurrent with pathogen challenge. Exposure to prolonged restraint significantly enhanced C. rodentium-induced infectious colitis in resistant mice, as measured by increases in colonic histopathology, colonic inflammatory mediator gene production, and pathogen translocation from the colon to the spleen. It was further tested if the beneficial bacterium Lactobacillus reuteri could reduce the stressor-enhanced susceptibility to C. rodentium-enhanced infectious colitis. While L. reuteri treatment did not reduce all aspects of stressor-enhanced infectious colitis, it did significantly reduce pathogen translocation from the colon to the spleen. Taken together, these data demonstrate the deleterious effects that prolonged stressor exposure can have at the onset of a gastrointestinal infection by its ability to render a resistant mouse highly susceptible to C. rodentium. Probiotic treatment ameliorated the systemic manifestations of stress on colonic infection.

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“…Some probiotics can directly kill or inhibit growth of pathogenic bacteria through the release of antimicrobial factors such as lactic and acetic acid, hydrogen peroxide, and bacteriocins [14,35,37]. The bacteriocin family is a group of proteins which vary in size, biochemical properties, microbial target and mode of action.…”

Section: Probiotic-induced Suppression Of Pathogen Growthmentioning

confidence: 99%

Probiotics as a promising treatment for inflammatory bowel disease

Mikov¹,

Stojančević²,

Bojić³

2014

Hosp Pharm Int Multi J

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SUMMARYTreatment of chronic inflammatory gastrointestinal conditions such as inflammatory bowel disease (IBD) is difficult due to the ambiguity surrounding their precise etiology. Complex interaction of genetic, microbial and environmental factors leads to sustained activation of the mucosal immune system resulting in active inflammation. Despite the efficacy of conventional therapy, significant side effects can occur, highlighting the need for novel treatment approaches to IBD. Since gut microflora appears to play a significant role in IBD, manipulation of its composition and activity by administering beneficial bacteria -probiotics, has been identified as a potential therapeutic option. Probiotic bacteria are able to modify and improve the intestinal environment and subsequently reduce the severity of intestinal inflammation associated with IBD. Clinical evidence suggest that probiotics can maintain remission in Ulcerative colitis (UC) and Crohn's disease (CD) but there are no convincing reports on the effectiveness in patients with more severe active forms of IBD. This review will explore various mechanisms how probiotics may affect IBD and summarize the current knowledge regarding the role of probiotics in IBD.

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Bacterial-mucosal interactions in inflammatory bowel disease—an alliance gone bad

Cited by 96 publications

References 121 publications

The Impact of Probiotics on the Gastrointestinal Physiology

The Impact of Probiotics on the Gastrointestinal Physiology

Probiotic Lactobacillus reuteri Attenuates the Stressor-Enhanced Severity of Citrobacter rodentium Infection

Probiotics as a promising treatment for inflammatory bowel disease

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