Bacterial resistance evolution by recruitment of super‐integron gene cassettes

Rowe‐Magnus, Dean A.; Guérout, Anne-Marie; Mazel, Didier

doi:10.1046/j.1365-2958.2002.02861.x

Cited by 200 publications

(146 citation statements)

References 62 publications

(75 reference statements)

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“…1 and Table 6, which is published as supporting information on the PNAS web site). One-third of the putatively absent genes reside on the small chromosome, and approximately half of these genes appear to lie within the integron island, a gene-capture system (53,54). Collectively, our results suggest that these four non-O1, non-O139 strains have a phylogenetic origin that is quite different from O1 strains.…”

Section: Discussionmentioning

confidence: 72%

Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system

Dziejman

Serruto²,

Tam³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

201

212

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Non-O1, non-O139 Vibrio cholerae can cause gastroenteritis and extraintestinal infections, but, unlike O1 and O139 strains of V. cholerae, little is known about the virulence gene content of non-O1, non-O139 strains and their phylogenetic relationship to other pathogenic V. cholerae. Comparative genomic microarray analysis of four pathogenic non-O1, non-O139 strains indicates that these strains are quite divergent from O1 and O139 strains. Genomic sequence analysis of a non-O1, non-O139 strain (AM-19226) that appeared particularly pathogenic in experimental animals suggests that this strain carries a type III secretion system (TTSS) that is related to the TTSS2 gene cluster found in a pandemic clone of Vibrio parahaemolyticus. The genes for this V. cholerae TTSS system appear to be present in many clinical and environmental non-O1, non-O139 strains, including at least one clone that is globally distributed. We hypothesize that the TTSS present in some pathogenic strains of non-O1, non-O139

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Section: Discussionmentioning

confidence: 72%

Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system

Dziejman

Serruto²,

Tam³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

201

212

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“…Integrons are the main pathway of genetic resistance for some bacteria. Resistance genes move among chromosomes, plasmids and transposons, leading to the spread of resistance among bacteria (Rowe-Magnus et al, 2002). There is a higher carrying rate of int1 than other types of integrons in Gram-negative bacteria, especially the Enterobacteriaceae (Gebreyes & Altier, 2002).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial resistance, presence of integrons and biofilm formation ofSalmonellaPullorum isolates from eastern China (1962–2010)

Gong

Zhu

et al. 2013

Avian Pathology

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Three hundred and thirty-seven isolates of Salmonella Pullorum from eastern China between 1962 and 2010 were characterized for antimicrobial susceptibility (disk diffusion method), the presence of integrons (polymerase chain reaction followed by sequencing) and the ability to form biofilms (semi-quantitative adherence assay). Two hundred and fifty-eight isolates (76.6%) exhibited multiple drug resistance (MDR; resistant to at least three different classes of antimicrobials), and the level of drug resistance is increasing with time. There were three isolates (9.4%) exhibiting MDR from 1962 to 1968. MDR rates began to increase for isolates between 1970 to 1979 and 1980 to 1987 (64.6 to 78.7%). The MDR rates reached 96.6% for isolates between 1990 and 2010. Polymerase chain reaction screening for integrons showed that 75 isolates (22.3%) were positive for class 1 integrons while none were positive for class 2 integrons. All of the class 1 integron-positive isolates exhibited MDR and were more frequently resistant than the negative isolates. Two hundred and twenty isolates (65.3%) had the ability to form biofilms, and bacterial resistance levels to cefamandole, trimethoprim and trimethoprim/sulfamethoxazole were significantly higher for biofilm-positive groups than the biofilm-negative groups. Our data show that multidrug resistance is common among S. Pullorum isolated from eastern China, being more frequent after 1990 than before 1990, and the presence of class 1 integrons is associated with multidrug resistance.

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“…Bacterial populations can respond to the threat of an antimicrobial agent by evolving some type of resistance mechanism(s) [138,159]. The imposed selective pressure results in the development of a corresponding resistance determinant, either through direct acquistition or intrinsically by modification of a host gene target, designed to facilitate evasion of the inhibitory substance.…”

Section: Genetic Mechanisms Associatedmentioning

confidence: 99%

“…Integron structures play a pivotal role and have been identified in several Gram-negative bacterial species including food-borne pathogens, such as Salmonella spp., E. coli and Shigella spp. [31,138,159]. Studies are now reporting the existence of these structures in Campylobacter and therefore their role and contribution to antimicrobial resistance must be assessed [76,113].…”

Section: Mdr-mediated By Antimicrobial Efflux Systemsmentioning

confidence: 99%

Campylobacter

et al. 2005

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-Species within the genus, Campylobacter, have emerged over the last three decades as significant clinical pathogens, particularly of human public health concern, where the majority of acute bacterial enteritis in the Western world is due to these organisms. Of particular concern are the species, C. jejuni and C. coli, which are responsible for most of these gastrointestinal-related infections. Although these organisms have already emerged as causative agents of zoonoses, several aspects of their epidemiology and pathophysiology are only beginning to emerge. Trends in increasing antibiotic resistance are beginning to emerge with oral antibiotics, which may be the drug of choice for when it is necessary to intervene chemotherapeutically. This review wishes to examine (i) emerging clinical aspects of the disease, such as Guillain Barré syndrome (GBS), (ii) the association between these organisms and poultry as a natural host, (iii) environmental aspects of Campylobacter epidemiology, (iv) the emergence of atypical campylobacters (v) emerging trends in antibiotic resistance, (vi) adoption of modern methods for the detection of campylobacters.

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Bacterial resistance evolution by recruitment of super‐integron gene cassettes

Abstract: clinically relevant pathogens at high frequency. These results demonstrate that otherwise phenotypically sensitive strains may still be a genetic source for the evolution of resistance to clinically relevant antibiotics through integron-mediated recombination events.

Cited by 200 publications

References 62 publications

Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system

Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system

Antimicrobial resistance, presence of integrons and biofilm formation ofSalmonellaPullorum isolates from eastern China (1962–2010)

Campylobacter

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