Bacterial resistance to silver in wound care

Percival, Steven L.; Bowler, Philip G; Russell, David J.

doi:10.1016/j.jhin.2004.11.014

Cited by 758 publications

(443 citation statements)

References 84 publications

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“…The reduction of toxicity of silver used in therapy can be achieved by forming organic complexes. Among commonly known and used complexes are: silver sulfadiazine salt [38,39] and silver complexes with sulfonamide drugs, which act against Gram-negative and Grampositive bacteria [40]. Colloidal silver or immobilized silver nanoparticles e.g.…”

Section: Silver Complexes With Ty In the Supramolecular Cr Systemmentioning

confidence: 99%

Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy

Natkaniec

Jagusiak

Rybarska

et al. 2017

Self-Assembled Molecules – New Kind of Protein Ligands

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The antimicrobial activity of metal ions, especially silver ions, has been known since ancient times. Consequently, finding an accessible, cheap and efficient carrier of metal ions remains an important challenge in molecular biology. The supramolecular system presented in this chapter consists of a mixture of Congo red and Titan yellow molecules forming a supramolecular ligand which is a potent complexing agent of silver ions. Delivery of ions in complex with supramolecular dye is advantageous due to the reduced toxicity. In addition, the use of Congo red provides selective action and -thanks to increased solubility -facilitates efficient dispersion of the carrier dye and excretion from the organism.

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Section: Silver Complexes With Ty In the Supramolecular Cr Systemmentioning

confidence: 99%

Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy

Natkaniec

Jagusiak

Rybarska

et al. 2017

Self-Assembled Molecules – New Kind of Protein Ligands

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show abstract

“…The antimicrobial activity of silver is well established (Percival et al 2005) and silver has been incorporated into many medical products (e.g. catheters, plasters) where it can limit the growth of bacteria and the development of biofilms (Adams et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

et al. 2014

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The antimicrobial drug candidate 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene silver(I) acetate (SBC3) was evaluated for its ability to function in vivo using larvae of Galleria mellonella. A SBC3 concentration of 25 lg/ml inhibited the growth of Staphylococcus aureus by 71.2 % and Candida albicans by 86.2 % in vitro. Larvae inoculated with 20 ll of SBC3 solution showed no ill effects up to a concentration of 250 lg/ml but administration of 500 lg/ml resulted in a 40 % reduction in larval survival and administration of a dose of 1,000 lg/ml resulted in total larval death at 24 h. Larvae inoculated with S. aureus or C. albicans and subsequently administered SBC3 showed increased survival. Administration of SBC3 to larvae did not boost the insect immune response as indicated by lack of an increase in the density of circulating haemocytes (immune cells). The abundance of a number of proteins involved in the insect immune response was reduced in larvae that received 20 ll SBC3 solution of 100 lg/ml. This is the first demonstration of the in vivo activity of SBC3 against S. aureus and C. albicans and demonstrates that SBC3 does not stimulate a non-specific immune response in larvae.

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“…29 It reacts with different membrane or enzyme proteins, leading to protein denaturation and interference of energy production. Other modes of action are interference of DNA replication and disruption of bacterial cell wall integrity, all ultimately leading to cell death.…”

Section: Discussionmentioning

confidence: 99%

No efficacy of silver bone cement in the prevention of methicillin‐sensitive Staphylococcal infections in a rabbit contaminated implant bed model

Moojen

Charles

Fleer

et al. 2009

Journal Orthopaedic Research

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Data from literature showed that a new type of metallic silver PMMA cement had good results in infection prophylaxis. This study investigated the in vivo efficacy of silver cement in the prevention of methicillin-sensitive Staphylococcal infections, compared to plain and tobramycin-containing cement. In 48 rabbits, 0.6% silver, 1% silver, plain, or tobramycin PMMA cement was injected into the femoral medullary canal after contamination with 10 5 , 10 6 , or 10 7 colony forming units (CFU) Staphylococcus aureus. After 14 days, bone was collected for bacteriology and histopathology. All plain and silver cement rabbits were infected, whereas only two tobra rabbits were infected (p < 0.001). The number of bacteria cultured ( 10 logCFU) from bone adjacent to the cement, was 6.4 AE 0.3 and 6.1 AE 0.3 for the 0.6% and 1% silver rabbits. For the rabbits with plain and tobra cement, this was 6.2 AE 0.2 (p > 0.95) and 0.0 AE 0.0 (p < 0.001), respectively. Two tobra rabbits had a positive culture of a distal bone sample. Histological sections of plain, 0.6%, and 1% silver rabbits all showed signs of infection; these signs were absent in the tobra rabbits. Silver and plain cement were not effective in preventing infection, whereas tobra cement was effective. As silver cement predominantly exhibits an antimicrobial effect at the direct cement surface, this cement seems less useful in situations where there are bacteria present in surrounding tissues, like revision surgery. Whether silver cement has relevance in the prevention of bacterial colonization of cement remains to be determined. ß

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Bacterial resistance to silver in wound care

Cited by 758 publications

References 84 publications

Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy

Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

No efficacy of silver bone cement in the prevention of methicillin‐sensitive Staphylococcal infections in a rabbit contaminated implant bed model

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