Bacterial Species Associated With Human Inflammatory Bowel Disease and Their Pathogenic Mechanisms

Zhang, Li; Liu, Fang; Xue, Jessica; Lee, Seul A.; Liu, Lu; Riordan, Stephen M.

doi:10.3389/fmicb.2022.801892

Cited by 35 publications

(32 citation statements)

References 119 publications

(151 reference statements)

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“…Although some strains of B.fragilis (e.g., enterotoxigenic B.fragilis ) are enteric pathogens [ 122 ], other commensal strains detected on the inflamed colonic mucosa of CD and UC paediatric patients produce surface immunomodulatory capsular polysaccharide A (PSA) [ 123 ], which has been found in vitro to increase cytokine IL-10 production, inhibit LPS-induced monocyte TNF-α, and induce CD39 + Foxp3 + T regs in a DC-dependent manner [ 124 ]. It has been shown that B.fragilis with a PSA on foetal enterocytes inhibits IL-1β-induced IL-8 production by binding to the TLR2 receptor on CD4 lymphocytes to promote the proliferation of FOXP3 + T regs cells, resulting in increased IL-10 production [ 125 ].…”

Section: Gut Microbiota-derived Scfas As Therapeutic Potential Agents...mentioning

confidence: 99%

The Therapeutic Role of Short-Chain Fatty Acids Mediated Very Low-Calorie Ketogenic Diet–Gut Microbiota Relationships in Paediatric Inflammatory Bowel Diseases

Alsharairi

2022

Nutrients

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The very low-calorie ketogenic diet (VLCKD) has been recognized as a promising dietary regimen for the treatment of several diseases. Short-chain fatty acids (SCFAs) produced by anaerobic bacterial fermentation of indigestible dietary fibre in the gut have potential value for their underlying epigenetic role in the treatment of obesity and asthma-related inflammation through mediating the relationships between VLCKD and the infant gut microbiota. However, it is still unclear how VLCKD might influence gut microbiota composition in children, and how SCFAs could play a role in the treatment of inflammatory bowel disease (IBD). To overcome this knowledge gap, this review aims to investigate the role of SCFAs as key epigenetic metabolites that mediate VLCKD–gut microbiota relationships in children, and their therapeutic potential in IBD.

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Section: Gut Microbiota-derived Scfas As Therapeutic Potential Agents...mentioning

confidence: 99%

The Therapeutic Role of Short-Chain Fatty Acids Mediated Very Low-Calorie Ketogenic Diet–Gut Microbiota Relationships in Paediatric Inflammatory Bowel Diseases

Alsharairi

2022

Nutrients

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“…In addition, several species of GM in pathological contexts are related to increased oxidative stress and inflammation [37]. Increased abundance of several bacteria species such as Enterotoxigenic B. fragilis, Fusobacterium varium, Adherent-invasive Escherichia coli, Campylobacter concisus, and Fusobacterium nucleatum is linked with inflammatory diseases such as inflammatory bowel disease (IBD) and metabolic-associated fat liver disease (MAFLD), respectively [38][39][40][41]. Oxidative stress-mediated by the human microbiome occurs through its ability to alter the cellular ROS by modulating mitochondrial activity [42].…”

Section: The Possible Crosstalk Between Gut Microbiota and Telomere L...mentioning

confidence: 99%

The Emerging Role of the Aging Process and Exercise Training on the Crosstalk between Gut Microbiota and Telomere Length

Assis

Neto

Ribeiro

et al. 2022

IJERPH

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Aging is a natural process of organism deterioration, which possibly impairs multiple physiological functions. These harmful effects are linked to an accumulation of somatic mutations, oxidative stress, low-grade inflammation, protein damage, and mitochondrial dysfunction. It is known that these factors are capable of inducing telomere shortening, as well as intestinal dysbiosis. Otherwise, among the biological mechanisms triggered by physical exercise, the attenuation of pro-inflammatory mediators accompanied by redox state improvement can be the main mediators for microbiota homeostasis and telomere wear prevention. Thus, this review highlights how oxidative stress, inflammation, telomere attrition, and gut microbiota (GM) dysbiosis are interconnected. Above all, we provide a logical foundation for unraveling the role of physical exercise in this process. Based on the studies summarized in this article, exercise training can increase the biodiversity of beneficial microbial species, decrease low-grade inflammation and improve oxidative metabolism, these factors together possibly reduce telomeric shortening.

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“…Other possible pathogens in the exacerbation of the IBD disease are Mycobacterium avium subspecies paratuberculosis, Clostridium difficile, Listeria monocytogenes, and Campylobacter concisus, as well as viruses, including cytomegalovirus, Epstein-Barr virus, and measles virus [17,81]. In addition, a number of pathogenic parasites may involve in the progression of this disease.…”

Section: Ibd and Gut Microbiotamentioning

confidence: 99%

“…In addition, a number of pathogenic parasites may involve in the progression of this disease. Overexposure of immune system in the presence of too many bacterial materials could also cause the loss of immunological tolerance to the bacteria, which are generally considered the normal flora in the gut [81]. Some of the individual bacterial species that associate with human IBD are reviewed here.…”

Section: Ibd and Gut Microbiotamentioning

confidence: 99%

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Gut Microbiota and Inflammatory Bowel Disease

Vakili¹,

Shoaei²,

Esfandiari³

et al. 2022

Effect of Microbiota on Health and Disease

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Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder that includes Crohn’s disease and ulcerative colitis. Ulcerative colitis involves the distal colon, proximal colon, and cecum and can lead to ulcerations and bleeding. Crohn’s disease appears as patched lesions in the gastrointestinal tract and inflammation, stenosis, or fistulas. IBD affects millions of people worldwide and has been associated with high morbidity and mortality. Our intestine is colonized by trillions of microorganisms (including bacteria, viruses, fungi, and protozoa), which constitutes the microbiota. Reduction of bacteria with anti-inflammatory capacities and increase of bacteria with inflammatory capacities are observed in patients with IBD when compared with healthy individuals. Microbial balance is needed for the development of a healthy gut and a symbiotic microbiota without problems. Any disturbance in that balance leads to dysbiosis and the host may become more susceptible to disease. Some alteration in the microbiome is protective or causative; thus, we selectively will review IBD disease, pathogenesis, and potential roles of some members of microbiota in IBD. In this chapter, we also explain the therapeutic approaches targeting microbiota (probiotics, prebiotics, postbiotics) and the relationship between gut microbiota imbalance, and how defects in this dysbiosis can lead to disease.

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Bacterial Species Associated With Human Inflammatory Bowel Disease and Their Pathogenic Mechanisms

Cited by 35 publications

References 119 publications

The Therapeutic Role of Short-Chain Fatty Acids Mediated Very Low-Calorie Ketogenic Diet–Gut Microbiota Relationships in Paediatric Inflammatory Bowel Diseases

The Therapeutic Role of Short-Chain Fatty Acids Mediated Very Low-Calorie Ketogenic Diet–Gut Microbiota Relationships in Paediatric Inflammatory Bowel Diseases

The Emerging Role of the Aging Process and Exercise Training on the Crosstalk between Gut Microbiota and Telomere Length

Gut Microbiota and Inflammatory Bowel Disease

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