Bacterial spore coat protein kinases: A new twist to an old story

Scott, John D.; Newton, Alexandra C.

doi:10.1073/pnas.1607004113

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…It proved to be an atypical protein kinase, which has an essential role in endospore formation by phosphorylating other structural proteins, such as CotB and CotG. Knockout of the encoding cotH gene had a pleiotropic effect on the structure of the outer spore coat, as well as the development of a germination-deficient phenotype ( 16 – 18 ).…”

Section: Introductionmentioning

confidence: 99%

cotH Genes Are Necessary for Normal Spore Formation and Virulence in Mucor lusitanicus

Szebenyi

Gebremariam

et al. 2023

mBio

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Section: Introductionmentioning

confidence: 99%

cotH Genes Are Necessary for Normal Spore Formation and Virulence in Mucor lusitanicus

Szebenyi

Gebremariam

et al. 2023

mBio

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A bright future in medicine for chemical engineering

Langer,

Peppas

2024

Nat Chem Eng

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Chemical engineering principles will continue to help scientists design and optimize new medical devices, treatments and modalities. This Comment reflects on historical developments and potential opportunities in medicine for chemical engineering.In a paper published 20 years ago, we gave a detailed analysis of the early days of biomedical engineering and the influence chemical engineering had in medicine 1 . Indeed, chemical engineers have long used their background in fluid mechanics, materials engineering, mass transfer, reaction systems, control theory and process design to contribute to many areas of medicine. These include the development of artificial organs; blood rheology and thrombosis; tissue engineering; regenerative medicine; advanced biomaterials and medical devices; controlled drug delivery systems; genetic therapies; advanced vaccine development; medical imaging; biosensors; approaches to improved enzyme characteristics by immobilizing them on appropriate supports, placing them in organic solvents or using directed evolution; and contributions to synthetic biology, such as enabling mammalian cells to take on new functions by designing appropriate molecular switching systems 2-6 . Developing linear and nonlinear mathematical models for the analysis of advanced biomedical problems is an area where chemical engineers have been active for many years 7,8 . A recent example where mathematical models are proving useful is in predicting optimal vaccine schedules and developing new vaccines 9 . Biomedical engineering has become an increasingly important part of chemical engineering research and education in the past 60 years. Chemical engineers are well suited to address interdisciplinary problems, in particular, those requiring convergence 10 and the integration of complex molecular systems 8 . This Comment provides our perspectives on several historical developments and future opportunities in medicine for chemical engineering.

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Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages

Gangwal

Kumar

Sangwan

et al. 2023

FEMS Microbiology Reviews

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Protein phosphorylation is a universal mechanism regulating a wide range of cellular responses across all domains of life. The antagonistic activities of kinases and phosphatases can orchestrate the life cycle of an organism. The availability of bacterial genome sequences, particularly Bacillus species, followed by proteomics and functional studies have aided in the identification of putative protein kinases and protein phosphatases, and their downstream substrates. Several studies have established the role of phosphorylation in different physiological states of Bacillus species as they pass through various life stages such as sporulation, germination, and biofilm formation. The most common phosphorylation sites in Bacillus proteins are histidine, aspartate, tyrosine, serine, threonine, and arginine residues. Protein phosphorylation can alter protein activity, structural conformational and protein-protein interactions, ultimately affecting the downstream pathways. In this review, we summarize the knowledge available in the field of Bacillus signaling, with a focus on the role of protein phosphorylation in its physiological processes.

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Bacterial spore coat protein kinases: A new twist to an old story

Cited by 4 publications

References 14 publications

cotH Genes Are Necessary for Normal Spore Formation and Virulence in Mucor lusitanicus

cotH Genes Are Necessary for Normal Spore Formation and Virulence in Mucor lusitanicus

A bright future in medicine for chemical engineering

Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages

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