Bacterial Urinary Tract Infections Associated with Transitional Cell Carcinoma in Dogs

Budreckis, D. M.; Byrne, Barbara A.; Pollard, Rachel E.; Rebhun, Robert B.; Rodríguez, C. O.; Skorupski, Katherine A

doi:10.1111/jvim.12578

Cited by 38 publications

(42 citation statements)

References 24 publications

(86 reference statements)

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“…The female:male ratio (1.4:1) as well as the urinary bladder trigone being the most common tumor site were similar to previous reports [1, 3, 4, 8]. Detection of a concurrent UTI in 42% of the dogs with TCC/PCA (both treatment-naïve dogs and dogs undergoing anticancer therapy) and the spectrum of organisms isolated are also in line with the results of others [37]. …”

Section: Discussionsupporting

confidence: 90%

Diagnostic performance of the urinary canine calgranulins in dogs with lower urinary or urogenital tract carcinoma

et al. 2017

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BackgroundOnset of canine transitional cell carcinoma (TCC) and prostatic carcinoma (PCA) is usually insidious with dogs presenting at an advanced stage of the disease. A biomarker that can facilitate early detection of TCC/PCA and improve patient survival would be useful. S100A8/A9 (calgranulin A/B or calprotectin) and S100A12 (calgranulin C) are expressed by cells of the innate immune system and are associated with several inflammatory disorders. S100A8/A9 is also expressed by epithelial cells after malignant transformation and is involved in the regulation of cell proliferation and metastasis. S100A8/A9 is up-regulated in human PCA and TCC, whereas the results for S100A12 have been ambiguous. Also, the urine S100A8/A9-to-S100A12 ratio (uCalR) may have potential as a marker for canine TCC/PCA. Aim of the study was to evaluate the diagnostic accuracy of the urinary S100/calgranulins to detect TCC/PCA in dogs by using data and urine samples from 164 dogs with TCC/PCA, non-neoplastic urinary tract disease, other neoplasms, or urinary tract infections, and 75 healthy controls (nested case-control study). Urine S100A8/A9 and S100A12 (measured by species-specific radioimmunoassays and normalized against urine specific gravity [S100A8/A9USG; S100A12USG], urine creatinine concentration, and urine protein concentration and the uCalR were compared among the groups of dogs.ResultsS100A8/A9USG had the highest sensitivity (96%) and specificity (66%) to detect TCC/PCA, with specificity reaching 75% after excluding dogs with a urinary tract infection. The uCalR best distinguished dogs with TCC/PCA from dogs with a urinary tract infection (sensitivity: 91%, specificity: 60%). Using a S100A8/A9USG ≥ 109.9 to screen dogs ≥6 years of age for TCC/PCA yielded a negative predictive value of 100%.ConclusionsS100A8/A9USG and uCalR may have utility for diagnosing TCC/PCA in dogs, and S100A8/A9USG may be a good screening test for canine TCC/PCA.

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Section: Discussionsupporting

confidence: 90%

Diagnostic performance of the urinary canine calgranulins in dogs with lower urinary or urogenital tract carcinoma

et al. 2017

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“…Univariate log binomial analyses were used to identify potential predictor variables for use in multivariate models. Those predictors with a Wald P value of Յ0.3, along with biologically plausible predictors and risk factors described in the literature, were used to build multivariate models (39,40). Predictor variables were selected in stepwise manner, using backwards selection with a 10% change-in-estimate criterion for inclusion in the final model.…”

Section: Methodsmentioning

confidence: 99%

Population Structure and Antimicrobial Resistance of Canine Uropathogenic Escherichia coli

et al. 2018

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is the most common cause of human and canine urinary tract infection (UTI). Clonal groups, often with high levels of antimicrobial resistance, are a major component of the population that causes human UTI. While little is known about the population structure of that causes UTI in dogs, there is evidence that dogs and humans can share fecal strains of and that human-associated strains can cause disease in dogs. In order to better characterize the strains that cause canine UTI, we analyzed 295 isolates obtained from canine urine samples from five veterinary diagnostic laboratories and analyzed their multilocus sequence types, phenotypic and genotypic antimicrobial resistance profiles, and virulence-associated gene repertoires. Sequence type 372 (ST372), an infrequent human pathogen, was the predominant sequence type in dogs at all locations. Extended-spectrum β-lactamase-producing isolates with genes were uncommon in canine isolates but when present were often associated with sequence types that have been described in human infections. This provides support for occasional cross-host-species sharing of strains that cause extraintestinal disease and highlights the importance of understanding the role of companion animals in the overall transmission patterns of extraintestinal pathogenic .

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“…Examples of indications include secondary infections in patients with bladder and urethral carcinomas (Boudreaux 2014, Budreckis and others 2015), and in gross oral tumours.…”

Section: Medical Therapymentioning

confidence: 99%

Palliative care in small animal oncology

Mason¹

2016

In Practice

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Cancer is a common diagnosis in companion animals and, increasingly, clients choose to pursue treatment for their pets. Veterinary oncology is a rapidly growing field and diagnostic and treatment options for animals with cancer are constantly improving and becoming more widely available. Treatment outcomes can be good, but in many cases definitive treatment is not an option and palliative treatment is necessary. This article explores the palliative care of dogs and cats that have been diagnosed with cancer and summarises the various treatment options, with a particular focus on quality of life and the role of communication in the decision-making process.

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Bacterial Urinary Tract Infections Associated with Transitional Cell Carcinoma in Dogs

Cited by 38 publications

References 24 publications

Diagnostic performance of the urinary canine calgranulins in dogs with lower urinary or urogenital tract carcinoma

Diagnostic performance of the urinary canine calgranulins in dogs with lower urinary or urogenital tract carcinoma

Population Structure and Antimicrobial Resistance of Canine Uropathogenic Escherichia coli

Palliative care in small animal oncology

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