Bacterial vaginosis and past chlamydial infection are strongly and independently associated with tubal infertility but do not affect in vitro fertilization success rates

Gaudoin, Marco; Rekha, P L; Morris, Amanda Sheffield; Lynch, J; Acharya, Umesh

doi:10.1016/s0015-0282(99)00310-6

Cited by 59 publications

(59 citation statements)

References 6 publications

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“…A profound number of other investigators [1,[5][6][7] were not been able to demonstrate a decrease in pregnancy rates in the presence of serum anti-C. trachomatis IgG. In association with their results, in current study IVF outcome, expressed by clinical pregnancy, life birth and miscarriage rates, was unrelated to anti-chlamydial antibody status of TFI patients.…”

Section: Discussionsupporting

confidence: 60%

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Association between anti-chlamydial immunity and IVF outcome

Müller¹,

Savicheva²,

Kogan³

et al. 2015

Gynecological Endocrinology

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Background: Elevated antibody titers to Chlamydia trachomatis are detected in up to 70% of women with tubal factor infertility (TFI). In order to evaluate the influence of past chlamydial infection on the results of IVF treatment, a prospective cohort study was performed. Materials and methods: A total of 242 women with TFI were enrolled in the study. Serum samples (n ¼ 242) and follicular fluid (n ¼ 197) were analyzed using enzyme-linked immunosorbent assay for anti-C. trachomatis IgG, IgA, IgM and anti-chlamydial heat shock protein 60 kDa IgG. Results: ''Poor response'' to ovarian stimulation was two times more frequent in seropositive subjects (22.9% versus 13.3%, p ¼ 0.039). Seropositive and seronegative women had similar IVF outcomes, expressed by clinical pregnancy (20.5% versus 25.0%), life birth (13.1% versus 20.0%) and miscarriage rates (36.0% versus 16.7%, p ¼ 0.092). Incidence of missed abortion after IVF was higher in women with previous exposure to C. trachomatis (28.0%) as compared to those without antibodies (3.3%), p ¼ 0.018. Conclusions: Anti-chlamydial antibody detection is not related to oocyte maturity, embryo quality, pregnancy and life birth rates. However, past chlamydial infection in TFI patients is associated with decreased IVF success: ''poor response'' to ovarian stimulation and missed abortion rate.

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Section: Discussionsupporting

confidence: 60%

“…Liccardi et al [4] established an association between chlamydial antibody positivity in serum and spontaneous abortion. In contrast, no relation between anti-chlamydial immunity and IVF failure was documented in comparable number of publications [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Association between anti-chlamydial immunity and IVF outcome

Müller¹,

Savicheva²,

Kogan³

et al. 2015

Gynecological Endocrinology

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“…In a study carried out by Malik et al the presence of C. trachomatis in infertile women was 28.1%, which was significantly higher than that of healthy women (3.3%) (P < 0.01) (19). Gaudoin et al reported that 91.2% of woman with tubal occlusion had IgG antichlamydial antibodies in their sera (20). …”

Section: Discussionmentioning

confidence: 99%

Comparison of Genital Chlamydia trachomatis Infection Incidence Between Women With Infertility and Healthy Women in Iran Using PCR and Immunofluorescence Methods

Marashi

Moulana

Fooladi

et al. 2014

Jundishapur J Microbiol

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Background:For a long time, infertility has been one of the most sequels in medical sciences with microbial agents as one group of its causes. The possible etiological role of Chlamydia trachomatis in infertility was suggested years ago, but it has not yet been proved completely. To decrease the severe involvements of C. trachomatis infections, screening by efficient diagnostic methods are necessary.Objectives:In this study we attempted to determine the incidence of C. trachomatis in infertile women and compared this with healthy women.Materials and Methods:This case-control study was performed on 150 infertile women with unknown causes and without physiological deficiency for infertility. The control group consisted of 200 fertile safe and impregnated women. Presence of C. trachomatis in the two groups was examined by direct and indirect immunofluorescence tests and PCR.Results:C. trachomatis was detected by direct immunofluorescence method in 23 (15.3%) infertile women compared and 7 (3.5%) healthy controls. Using indirect immunofluorescence tests, a positive test titer of 1:16 as well as the above results were detected in 34 (22.6%) of the infertile cases and 9 (4.5%) of the controls. C. trachomatis was detected by PCR method in 48 (32%) infertile women and 13 (8.7%) among the controls.Conclusions:The results of our study suggest that there is a significant association between C. trachomatis infection and female infertility.

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“…Several authors have suggested the impact of this infection on IVF success rates (7)(8)(9), whereas others denied this correlation (10).…”

mentioning

confidence: 99%

Autoimmune response to Chlamydia trachomatis infection and in vitro fertilization outcome

Pacchiarotti

Sbracia

Mohamed

et al. 2009

Fertility and Sterility

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Bacterial vaginosis and past chlamydial infection are strongly and independently associated with tubal infertility but do not affect in vitro fertilization success rates

Cited by 59 publications

References 6 publications

Association between anti-chlamydial immunity and IVF outcome

Association between anti-chlamydial immunity and IVF outcome

Comparison of Genital Chlamydia trachomatis Infection Incidence Between Women With Infertility and Healthy Women in Iran Using PCR and Immunofluorescence Methods

Autoimmune response to Chlamydia trachomatis infection and in vitro fertilization outcome

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