Comparison of Genital Chlamydia trachomatis Infection Incidence Between Women With Infertility and Healthy Women in Iran Using PCR and Immunofluorescence Methods

Marashi, Seyed Mahmoud Amin; Moulana, Zahra; Fooladi, Abbas Ali Imani; Karim, Mohammad Mashhadi

doi:10.5812/jjm.9450

Cited by 16 publications

(15 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As seen in Fig. 7, ORs for all these studies 26,31,43,47,48 except one 27 were above 1, P-values for three surveys were below 0.05, 31,47,48 the overall OR was 2.3 (95% CI, range: 1.1-4.6), and the overall P-value was 0.02;…”

Section: Discussionmentioning

confidence: 99%

Prevalence of genitalChlamydia trachomatisin Iran: a systematic review and meta-analysis

Ahmadi

Mirsalehian

Bahador

2015

Pathogens and Global Health

View full text Add to dashboard Cite

Objective: To determine the overall prevalence of Chlamydia trachomatis in Iranian males and females and to find out the effect of this bacterium on fertility potential and its association with urogenital symptoms. Methods: We searched both English and Persian electronic databases using keywords 'Chlamydia', 'Chlamydia trachomatis', 'prevalence', 'incidence', 'frequency', 'epidemiology' and 'Iran'. Finally, after some exclusion, 34 studies from different regions of Iran were included in our study, and a meta-analysis was performed to determine pooled prevalence estimates for each group. Results: C. trachomatis prevalence for women and men was high and ranged from 0 to 32.7% and 0 to 23.3%, respectively (95% CI). The pooled prevalence of the bacterium in the female population was 12.3% (95% CI: 10.6-14.2%) and in men was 10.9% (95% CI: 7.6-15.4%). A high level of heterogeneity was seen for both men (I 2 5 77.4%; P v 0.001) and women (I 2 5 77.5%; P v 0.001); but in men and not in women, some evidence for publication bias was observed [Egger's test (twotailed P 5 0.013); Begg's test (two-tailed P 5 0.025)]. In females analysis of symptomatic/infertile group with asymptomatic/fertile group in females, the overall OR was above 1 and the overall P-value was below zero. Conclusions: This bacterium may play a role in female infertility or be associated with clinical manifestations; thus, planning national programmes for adequate diagnosis of genital infections caused by this pathogen is necessary. Furthermore, screening strategies, particularly for asymptomatic individuals, and treatment of infected people can reduce consequent complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of genitalChlamydia trachomatisin Iran: a systematic review and meta-analysis

Ahmadi

Mirsalehian

Bahador

2015

Pathogens and Global Health

View full text Add to dashboard Cite

show abstract

“…Mohammed et al (2017) 90 Goshayeshi et al (2015) 58 Sisakht et al (2017) 76 Awwad et al (2003) 95 Bagheri et al (2018) 53 Safdari et al (2015) 74 Zahirnia et al (2018) 78 Mosbah and Nabiel (2016) 43 Mosbah and Nabiel (2016) 43 Nada et al (2015) 45 Mousavi et al (2014) 69 El−Sayed et al (2002) 42 Ahmadi et al (2016a) 48 Joolayi et al (2017) 62 Al-Thani (2013) 110 As'ad (2004) 94 Awad et al (2013) 112 Al-Ramahi et al (2008) 93 Mahafzah et al (2008) 96 Marashi et al (2014) 66 Javanmard et al (2018) 61 Jordan Ministry of Health (2004) 97 Al-Thani (2013) 110 Rashidi et al (2013) 71 Pourabbas et al (2018) 70 Dehghan et al (2017) 57 The Middle East and North Africa HIV/AIDS Epidemiology Synthesis Project (2017) 105 with miscarriage and in pregnant women-similar to that found in pregnant women in lowincome and middle income countries elsewhere. [213][214][215][216][217] This stigmatised and largely asymptomatic infection might not be visible to the public eye, but its reproductive health sequelae are visible, even if not explicitly linked to the underlying cause.…”

Section: Womenmentioning

confidence: 99%

“…Medical Education (2008) 67 Gdoura et al (2008) 178 Sadrpour et al (2013) 164 Al-Sweih et al (2012) 100 Ahmadi et al (2018) 49 Golshani et al (2007) 155 Dehghan et al (2017) 57 Moazenchi et al 2018159 Total Random effects model Heterogeneity: 93 Al-Ramahi et al (2008) 93 Joolayi et al (2017) 62 Al-Ramahi et al (2008) 93 Rashidi et al (2013) 71 Ahmed (2012) 167 Abdella et al (2015) 144 Hajikhani et al (2013) 156 Al-Ramahi et al (2008) 93 Joolayi et al (2017) 62 Mohammed et al (2017) 90 Siam and Hefzy (2012) 151 Kalantar et al (2007) 157 Gdoura et al (2001b) 177 Alfarraj et al (2015) 174 Dawood (2011) 169 Elkayal et al (2015) 146 Goshayeshi et al (2015) 58 Nada et al (2015) 45 Mousavi et al (2014) 69 Mansour Ghanaie (2014) 158 Marashi et al (2014) 66 Rashidi et al (2013) 71 Dehghan et al (2017) 57…”

Section: Prevalence (95% Ci)mentioning

confidence: 99%

Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

Smolak

Chemaitelly

Hermez

et al. 2019

The Lancet Global Health

View full text Add to dashboard Cite

Background The epidemiology of Chlamydia trachomatis in the Middle East and north Africa is poorly understood. We aimed to provide a comprehensive epidemiological assessment of C trachomatis infection in the Middle East and north Africa. Methods We did a systematic review of C trachomatis infection as well as a meta-analysis and meta-regression of C trachomatis prevalence. We searched PubMed and Embase, as well as regional and national databases up to March 13, 2019, using broad search terms with no language or year restrictions. Any document or report including biological measures for C trachomatis prevalence or incidence was eligible for inclusion. We extracted all measures of current (genital or rectal), recent, and ever infection with C trachomatis. We estimated pooled average prevalence in different populations using random-effects meta-analysis. Factors associated with prevalence and sources of betweenstudy heterogeneity were determined using meta-regression. Findings We identified a total of 1531 citations, of which 255 reports contributed to 552 C trachomatis prevalence measures from 20 countries. No incidence measures were identified. Pooled prevalence of current genital infection was 3•0% (95% CI 2•3-3•8) in general populations, 2•8% (1•0-5•2) in intermediate-risk populations, 13•2% (7•2-20•7) in female sex workers, 11•3% (9•0-13•7) in infertility clinic attendees, 12•4% (7•9-17•7) in women with miscarriage, 12•4% (9•4-15•7) in symptomatic women, and 17•4% (12•5-22•8) in symptomatic men. Pooled prevalence of current rectal infection was 7•7% (4•2-12•0) in men who have sex with men. Substantial between-study heterogeneity was found. Multivariable meta-regression explained 29•0% of variation. Population type was most strongly associated with prevalence. Additional associations were found with assay type, sample size, country, and sex, but not with sampling methodology or response rate (about 90% of studies used convenience sampling and >75% had unclear response rate). There was no evidence for temporal variation in prevalence between 1982 and 2018. Interpretation C trachomatis prevalence in the Middle East and north Africa is similar to other regions, but higher than expected given its sexually conservative norms. High prevalence in infertility clinic attendees and in women with miscarriage suggests a potential role for C trachomatis in poor reproductive health outcomes in this region.

show abstract

“…5 - 9 The association between C. trachomatis infection and infertility has been the subject of several research. A study in Iran 10 suggested the significant association between C. trachomatis infection and female infertility with a prevalence rate of 15.3%. The same finding was suggested by a study conducted in India, which confirmed the significant association between infertility and the duration of C. trachomatis infection.…”

mentioning

confidence: 99%

The prevalence of Chlamydia trachomatis infection among Saudi women attending the infertility clinic in Central Saudi Arabia

Al-Farraj

Somily

Al-Ssum

et al. 2015

SMJ

View full text Add to dashboard Cite

Objectives:To determine the prevalence of Chlamydia trachomatis (C. trachomatis) infection among Saudi women, its clinical presentation, and its association to infertility.Methods:This study was conducted between October 2012 and July 2013 at King Khalid University Hospital and King Abdulaziz University Hospital, Riyadh, Kingdom of Saudi Arabia. Female patients aged between 19 and 46 years old with infertility problems seen at both hospitals were recruited to join the study. A separate group of female patients without infertility problems was also recruited from both hospitals to serve as controls for the study. Endocervical swabs were collected from both groups of patients, and samples were analyzed using real time polymerase chain reaction.Results:There was a statistically significantly greater prevalence of C. trachomatis infection in infertile women (n=8, 8.0%) compared with the fertile group of women (n=1, 1.0%). The C. trachomatis infection was significantly correlated to infertility.Conclusion:A significant association between infertility and increased prevalence of C. trachomatis infection is shown in this study, thus, we suggest that screening for Chlamydial infection to be part of the routine investigation for infertility.

show abstract

Comparison of Genital Chlamydia trachomatis Infection Incidence Between Women With Infertility and Healthy Women in Iran Using PCR and Immunofluorescence Methods

Cited by 16 publications

References 16 publications

Prevalence of genitalChlamydia trachomatisin Iran: a systematic review and meta-analysis

Prevalence of genitalChlamydia trachomatisin Iran: a systematic review and meta-analysis

Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

The prevalence of Chlamydia trachomatis infection among Saudi women attending the infertility clinic in Central Saudi Arabia

Contact Info

Product

Resources

About