Bacterial Variants in Patients Treated With Chloramphenicol

Voureka, A.

doi:10.1016/s0140-6736(51)93498-8

Cited by 19 publications

(8 citation statements)

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“…Voureka observed bizarre bacterial forms in the urine of patients who were treated with chloramphenicol and also noted their reversion to the parent form after repeated subcultures (10). Ten years later Braude, Siemienski, and Jacobs reported a patient with Proteus pyelonephritis in whose urine round, osmotically fragile forms were found during penicillin therapy ( 11 ) .…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies regarding the pathogenesis of L-forms and protoplasts in urinary tract infection, direct microscopy has shown round, bizarre forms in the urine of patients with bacteriuria receiving antimicrobial agents (10,11). The present study differs from those previously reported in that a modified PPLO medium was used that will support the growth of bacterial variants in patients with chronic bacteriuria and permit further assessment of the role of these forms in the pathogenesis of renal infection.…”

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confidence: 98%

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Significance of bacterial variants in urine of patients with chronic bacteriuria.

Gutman¹,

Turck²,

Petersdorf³

et al. 1965

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

Significance of bacterial variants in urine of patients with chronic bacteriuria.

Gutman¹,

Turck²,

Petersdorf³

et al. 1965

J. Clin. Invest.

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“…Attempts to isolate stable small-colony forms of Escherichia coli K-12 or its auxotrophs by the techniques of Colwell(l946) and Voureka (1951) were without success. By the technique of Weed & Longfellow (1954) stable variants were isolated with relative ease from all strains, although the inhibitory concentration of cupric ions was found to be higher in the case of E. cot5 K-12 M) than with E. coli B (2.5 x 10-3 M).…”

Section: Isolation Of Small-colony Variantsmentioning

confidence: 99%

“…Rowley liquid media and also by their loss of certain fermentation capacities. Voureka (1951), by the use of chloramphenicol and specific antiserum, isolated from Escherichia coli a small-colony variant which differed from the parent strain only in its antibiotic sensitivities. Manten & Rowley (1953) produced small colony variants of E. coli by the use of chloramphenicol and normal serum, and showed that in most instances no change had arisen in any other character.…”

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confidence: 99%

Genetic Studies on Small-colony Variants of Escherichia coli K-12

Clowes

Rowley

1955

Journal of General Microbiology

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SUMMARY: Stable small-colony variants of Escherichia coli K-12 and several of its auxotrophs were isolated by treatment of cultures with copper sulphate solutions. These variants did not show any associated changes in nutritional, fermentative or serological characters. The small-colony forms showed normal recombining character in two instances, but in one variant the F -form showed a lower recombination rate and atypical transfer of markers. However, when rendered F + this variant behaved in a manner analogous to the normal F + parent strain. The results have been interpreted as evidence that the small-colony character can arise by a nuclear mutation at one of several possible genetic loci.

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“…This does not indicate that these antibiotics, alone or in combination with other factors, caused the production of L‐forms, but the possibility has to be considered. Voureka (14) found bacterial variants, including giant bizarre forms, in the urine of patients treated with chloramphenicol and concluded that they might account for the relapses.…”

Section: Commentmentioning

confidence: 99%

Bacterial L‐forms From Urinary‐tract Infections in a Veterans Hospital Population*

Conner

Coleman

Davis

et al. 1968

J American Geriatrics Society

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In a study of 115 patients with chronic and acute urinary‐tract infections, 26 (23 per cent) were found to have bacterial L‐forms in the urine which could be cultured in a special hypertonic medium. The most common genera of bacteria producing these forms were Proteus, Pseudomonas and Escherichia‐Aerobacter. Most of the patients had cystitis, pyelonephritis or a general diagnosis of “urinary‐tract infection.” In a case of acute exacerbation of chronic pyelonephritis, the L‐form of Proteus mirabilis appeared after eradication of the parent form with chloramphenicol. The L‐form was sensitive to erythromycin even though the parent form was not, and after therapy with this antibiotic the L‐form did not reappear for a ten‐month period of study. L‐forms occur frequently enough in the urine to warrant culturing for these forms specifically and considering the possible significance of L‐forms in relation to the type of urinary‐tract infection and the type of antibiotic therapy used.

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Bacterial Variants in Patients Treated With Chloramphenicol

Cited by 19 publications

References 0 publications

Significance of bacterial variants in urine of patients with chronic bacteriuria.

Significance of bacterial variants in urine of patients with chronic bacteriuria.

Genetic Studies on Small-colony Variants of Escherichia coli K-12

Bacterial L‐forms From Urinary‐tract Infections in a Veterans Hospital Population*

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