Bactericidal Activity of Streptomycin and Isoniazid Against Tubercle Bacilli

Singh, Balbir; Mitchison, D.A.

doi:10.1136/bmj.1.4854.130

Cited by 39 publications

(20 citation statements)

References 3 publications

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“…The higher of these (streptomycin 20 units/ml., isoniazid 2 ,ug./ml., NaPAS 100 ,ug./ml.) corresponded to the approximate peak serum concentrations found in patients treated with streptomycin at 1 g./day, isoniazid 200 mg./day or NaPAS 20 g./day (Singh & Mitchison, 1954; Nilsson, 1953). The lower concentrations (streptomycin 2 units/ml., isoniazid 0.2 pg./ml., NaPAS 10 ,ug./ml.)…”

Section: Methodssupporting

confidence: 62%

Bactericidal Activity of Streptomycin and Isoniazid in Combination with p-Aminosalicylic Acid against Mycobacterium tuberculosis

Singh¹,

Mitchison²

1955

Journal of General Microbiology

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The bactericidal activity of streptomycin, isoniazid and combinations of streptomycin and isoniazid against tubercle bacilli growing in Tween albumin medium was measured with and without the addition of p-aminosalicylic acid (PAS). When the concentrations of these compounds were about 4 to 16 times their minimal inhibitory concentrations, PAS did not influence this activity, but it was slightly increased when the concentrations were 10 times higher (equal to peak serum concentrations in treated patients). Combinations of the low concentrations of PAS + streptomycin or PAS + isoniazid usually only delayed the emergence of drugresistant bacilli, whereas combinations of the higher concentrations suppressed their growth.

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Section: Methodssupporting

confidence: 62%

Bactericidal Activity of Streptomycin and Isoniazid in Combination with p-Aminosalicylic Acid against Mycobacterium tuberculosis

Singh¹,

Mitchison²

1955

Journal of General Microbiology

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“…Streptomycin (5-(2,4-diguanidino-3,5,6-trihydroxy-cyclohexoxy)-4-[4,5-dihydroxy-6-(hydroxymethyl)-3-methylamino-tetrahydropyran-2-yl]oxy-3-hydroxy-2-methyl-tetrahydrofuran-3-carbaldehyde), an antibiotic produced by Streptomyces griseus that has long been used as a fungicide [37], also has bactericidal activity. Streptomycin interferes with amino acid synthesis.…”

Section: Effects On Amino Acids and Protein Synthesismentioning

confidence: 99%

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

et al. 2011

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Fungicides have been used widely in order to control fungal diseases and increase crop production. However, the effects of fungicides on microorganisms other than fungi remain unclear. The modes of action of fungicides were never well classified and presented, making difficult to estimate their possible nontarget effects. In this paper, the action modes and effects of fungicides targeting cell membrane components, protein synthesis, signal transduction, respiration, cell mitosis, and nucleic acid synthesis were classified, and their effects on nontarget microorganisms were reviewed. Modes of action and potential non-target effects on soil microorganisms should be considered in the selection of fungicide in order to protect the biological functions of soil and optimize the benefits derived from fungicide use in agricultural systems.

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“…The method of testing the bactericidal action of the compounds was described previously (Singh & Mitchison, 1954. The compounds were added to Tween albumin cultures of the H37Rv strain of Mycobacterium tuberculosis so that the final concentrations approximated to those found in the serum of patients treated with usual therapeutic doses.…”

Section: Methodsmentioning

confidence: 99%

The Bactericidal Activities of Combinations of Streptomycin, Isoniazid, p-Aminosalicylic Acid (PAS), Oxytetracycline (Terramycin) and Viomycin against Mycobacterium tuberculosis

Singh¹,

Mitchison²

1955

Journal of General Microbiology

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The bactericidal activities of mixtures of various chemotherapeutic drugs were tested against the H 37 Rv strain of Mycobacterium tuberculosis when growing in Tween albumin medium. Oxytetracycline (terramycin) antagonized the bactericidal activities of streptomycin, isoniazid and viomycin, whereas p-aminosalicylic acid (PAS) was slightly synergistic or did not influence their activities. Mixtures of viomycin and streptomycin were slightly less bactericidal than streptomycin alone, but more bactericidal than viomycin alone. Viomycin acted synergistically with isoniazid, and with isoniazid + streptomycin. The emergence of strains resistant to streptomycin, isoniazid or viomycin was not prevented in the cultures by the presence of oxytetracycline, probably because of its rapid inactivation. Drug resistance emerged in dual mixtures which included PAS, where the concentrations of streptomycin, isoniazid or PAS were low, but not when these concentrations were high. Resistant strains did not emerge in cultures containing viomycin + streptomycin or viomycin + isoniazid.

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Bactericidal Activity of Streptomycin and Isoniazid Against Tubercle Bacilli

Cited by 39 publications

References 3 publications

Bactericidal Activity of Streptomycin and Isoniazid in Combination with p-Aminosalicylic Acid against Mycobacterium tuberculosis

Bactericidal Activity of Streptomycin and Isoniazid in Combination with p-Aminosalicylic Acid against Mycobacterium tuberculosis

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

The Bactericidal Activities of Combinations of Streptomycin, Isoniazid, p-Aminosalicylic Acid (PAS), Oxytetracycline (Terramycin) and Viomycin against Mycobacterium tuberculosis

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