Bactericidal and antimicrobial effects of pure titanium and titanium alloy treated with short-term, low-energy UV irradiation

Itabashi, Terumi; Narita, Kouji; Ono, Akira; Wada, Kanichiro; Tanaka, Tsunehiro; Kumagai, Gentaro; Yamauchi, Ryota; Nakane, Akio; Ishibashi, Yasuyuki

doi:10.1302/2046-3758.62.2000619

Cited by 24 publications

(20 citation statements)

References 23 publications

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“…Many of the metals, including gold or silver, have been used so far for the preparation of NPs, and demonstrate relatively strong antibacterial properties. Titanium compounds, especially titanium dioxide, were also used as a bactericide, as evidenced by numerous in vitro studies on various bacteria including both Gram-positive and Gram-negative strains [56,[73][74][75]. The antibacterial properties of titanium dioxide can be enhanced by exposure to UV light.…”

Section: Tio 2 Nanoparticles Combined With Phthalocyaninesmentioning

confidence: 99%

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

et al. 2020

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Metallic and metal oxide nanoparticles (NPs), including titanium dioxide NPs, among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites and combinations with other molecules or biomolecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 nanoparticles, leading to hybrid materials. These nanostructures can reveal increased light absorption, allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer and antimicrobial therapies, many approaches utilizing titanium dioxide were tested. Results of selected studies presenting the scope of potential uses are discussed in this review.

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Section: Tio 2 Nanoparticles Combined With Phthalocyaninesmentioning

confidence: 99%

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

et al. 2020

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“…Yamauchi et al reported that the bone-implant contact (BIC) ratio for both Ti and Ti6Al4V UV-treated implants significantly increased at 2 weeks [ 3 ]. UV irradiation was also found to have an antimicrobial effect in the early stage after implantation [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Ultraviolet irradiation improves the hydrophilicity and osteo-conduction of hydroxyapatite

et al. 2020

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Background Treating a titanium or titanium alloy implant with ultraviolet (UV) light is known to improve its associated cell growth and osseointegration. However, little is known about the effect of UV irradiation on hydroxyapatite (HA), which is also used frequently in orthopaedic and dental surgery. Here we examined the effect of UV irradiation on the hydrophilicity of HA, and on its osteoconduction ability in rats. Methods HA implants of low and high porosity were treated with UV light, and photofunctionalisation was assessed by the contact angle of a water drop on the surface. HA implants were also inserted into rat femurs, and the rats were killed 2 or 4 weeks later. The bone volume and bone area ratio were calculated from microcomputed tomography and histological data. Results The contact angle of a water drop on HA implants of both porosities was significantly reduced after UV irradiation. In the rat femurs, there was no significant difference in the bone volume between the UV light-treated and control implants at 2 or 4 weeks. The bone area ratio for the UV light-treated versus control implants was significantly increased at 2 weeks, but there was no significant difference at 4 weeks. Conclusions The surface of UV-irradiated HA disks was hydrophilic, in contrast to that of non-irradiated HA disks. Photofunctionalisation accelerated the increase in the bone area ratio in the early healing stage. This technology can be applied to surgical cases requiring the early fusion of bone and HA.

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“…The light source mounted in the UVI device is a low-pressure mercury lamp, which emits UV light predominantly at 254 and 185 nm. Under these conditions, each Ti surface received approximately 8-10 mW/cm 2 of radiation 11) . UV5 corresponded to a dose of 3 J/cm 2 .…”

Section: Surface Treatmentmentioning

confidence: 99%

Influence of ultraviolet irradiation treatment on porcelain bond strength of titanium surfaces

et al. 2018

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To determine the effect of titanium (Ti) surface modification by ultraviolet irradiation (UVI) on the bond strength between Ti and porcelain. Grade 2 Ti plates were allotted to five groups: sandblasted (SA), 15 min UVI (UV), SA+5 min UVI (SA+UV5), SA+10 min UVI (SA+UV10), and SA+15 min UVI (SA+UV15). After surface treatment, porcelain was added. A precious metal (MC) was used for comparison with Ti. The effects of 24-h storage at room temperature versus thermal cycling only at 5 and 55°C in water were evaluated. Subsequently, the tensile strength of each sample was tested. Data were analyzed using one-way analysis of variance and the Tukey test. In both the room temperature and thermal cycling groups, the MC and SA+15 min UVI samples showed significantly greater bond strengths than the other samples (p<0.05). UVI processing efficiently increases the bond strength between porcelain and the Ti surface.

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Bactericidal and antimicrobial effects of pure titanium and titanium alloy treated with short-term, low-energy UV irradiation

Cited by 24 publications

References 23 publications

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ultraviolet irradiation improves the hydrophilicity and osteo-conduction of hydroxyapatite

Influence of ultraviolet irradiation treatment on porcelain bond strength of titanium surfaces

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