Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii

Liu, Qian; Harrington, David; Kohen, James; Vemulpad, Subramanyam; Jamie, Joanne F.

doi:10.1016/j.phytochem.2006.04.014

Cited by 46 publications

(68 citation statements)

References 21 publications

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“…This presumption has been supported by recently obtained data from Eremophila sturtii (Liu et al 2006). Eremophila sturtii, a species used as a traditional medicine for skin infections by different groups of Australian indigenous peoples, was found to contain a particular type of serrulatane, serrulatic acid, with bactericidal activity against S. aureus.…”

Section: Resultsmentioning

confidence: 58%

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Antimicrobial activity of some Australian plant species from the genus Eremophila

Ndi

Semple

Griesser

et al. 2007

J. Basic Microbiol.

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Plant species of the genus Eremophila (Myoporaceae) are native to Australia and are known to produce a diverse range of unusual secondary compounds. The purpose of this research was to examine the antimicrobial activity of 72 Eremophila species most of which had not been the subject of any previous pharmacological testing. Organic extracts of Eremophila species were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria and yeasts of medical importance. Extracts of a number of Eremophila species showed selective activity against Gram-positive bacteria with MICs for the most active species in the range of 16 to 62 microg/ml for Streptococcus species, and 62 to 250 microg/ml for standard strains of Staphylococcus aureus. Extracts with the greatest activity against standard strains were tested against 68 clinical isolates of multi-resistant methicillin-resistant S. aureus (mMRSA). The majority of the clinical isolates were susceptible to concentrations below 62.5 microg/ml for the extracts of E. drummondii, E. linearis, E. serrulata, E. acrida, E. neglecta, E. virens and a new undescribed species affiliated with E. prolata. The extract of E. virens inhibited growth of all 68 clinical mMRSA isolates at the minimum tested concentration of 31 microg/ml. This study has shown for the first time that a number of different Eremophila species manifest selective antibacterial activity against Gram-positive organisms which are important causes of human disease. It shows that there are several Eremophila species possessing interesting antibacterial activity besides those that have published traditional use. These may yield novel antibacterial compounds with potential to be used in biomedical applications.

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Section: Resultsmentioning

confidence: 58%

“…Recently a chemical investigation of the traditional medicinal species Eremophila sturtii has found a diterpenoid called serrulatic acid to be an active bactericidal component (Liu et al 2006).…”

mentioning

confidence: 99%

Antimicrobial activity of some Australian plant species from the genus Eremophila

Ndi

Semple

Griesser

et al. 2007

J. Basic Microbiol.

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“…Streptococcus pneumoniae (ARL 10589) was the most susceptible organism to all compounds tested with MIC p-INT values for compound (1) of 23 and 375 g mL −1 for compound (2). Liu et al (2006) have recently Fig. 4.…”

Section: Minimum Inhibitory Concentrations Of Compounds 1 2 Andmentioning

confidence: 99%

“…Liu et al (2006) have reported potent bactericidal activities of serrulatane acids isolated from Eremophila sturtii against Staphylococcus aureus. Seco-pseudopterosins, marine derived isoprenologues, isolated from the West Indian sea whip (Pseudopterogorgia elisabethae), which are structurally related to the serrulatanes, have been reported to exhibit potent anti-mycobacterial activity (Rodríguez et al, 1999;Rodríguez and Ramirez, 2001).…”

Section: Serrulatane Diterpenes As Active Constituents and Occurrencementioning

confidence: 99%

“…Links between parameters of low molecular size, surface area and conformation (including acyclicity) amongst 10 carbon monoterpenoids and inhibitory activity against Gram-negative organisms have been demonstrated by Griffin et al (1999), Griffin (2000). The serrulatane diterpene acids isolated from Eremophila sturtii which were shown by Liu et al (2006) to exhibit strong bactericidal activity against Staphylococcus aureus (ATCC 9144), were reported ineffective against the Gram-negative species Pseudomonas aeruginosa (ATCC 27853) and Escherichia coli (JM109).…”

Section: Serrulatane Diterpenes As Active Constituents and Occurrencementioning

confidence: 99%

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Identification of antibacterial constituents from the indigenous Australian medicinal plant Eremophila duttonii F. Muell. (Myoporaceae)

Smith

Tucker

Watson

et al. 2007

Journal of Ethnopharmacology

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Recent Advances in Stetter Reaction and Related Chemistry: An update

et al. 2020

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The Stetter reaction is actually a special CÀ C bond forming reaction through a 1,4-addition reaction in the presence of nucleophilic catalyst. It involves a reaction between aldehydes and Michael acceptors catalyzed by Nheterocyclic carbenes (NHC's) leading to preparation of 1,4dicarbonyl compounds via carbon-carbon bond formation. It offers a powerful approach to access 1,4-dicarbonyl compounds which are significant starting materials and inter-mediates in the synthesis of several heterocyclic systems, and bioactive heterocyclic framework which are present in natural products. In this review we try to underscore the recent advances in Stetter reaction and its applications from 2015 till date. Notably, we focused on the applications of Stetter reaction in the synthesis of various heterocyclic systems and total synthesis of natural products, which have largely been overlooked, previously.

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Bactericidal and cyclooxygenase inhibitory diterpenes from Eremophila sturtii

Cited by 46 publications

References 21 publications

Antimicrobial activity of some Australian plant species from the genus Eremophila

Antimicrobial activity of some Australian plant species from the genus Eremophila

Identification of antibacterial constituents from the indigenous Australian medicinal plant Eremophila duttonii F. Muell. (Myoporaceae)

Recent Advances in Stetter Reaction and Related Chemistry: An update

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